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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Research Project #438679
Research Project: Intestinal Microbial Ecology and Non-Antibiotic Strategies to Limit Shiga Toxin-Producing Escherichia coli (STEC) and Antimicrobial Resistance Transmission in Food Animals

Location: Food Safety and Enteric Pathogens Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Commercially available anti-human/-mouse monoclonal antibodies cross-reactive to agriculture and wildlife species - (Abstract Only)

Host-pathogen interactions during Shing toxin-producing Escherichia coli adherence and colonization in the bovine gut: A comprehensive review Reprint Icon - (Review Article)
Edison, L.K., Kudva, I.T., Kariyawasam, S. 2024. Host-pathogen interactions during STEC adherence and colonization in the bovine gut: A comprehensive review. Microorganisms.2024; 12(10):2009. https://doi.org/10.3390/microorganisms12102009.

Investigating the adherence factors of Escherichia coli at the bovine recto-anal junction Reprint Icon - (Peer Reviewed Journal)
Nawrocki, E.M., Kudva, I.T., Dudley, E.G. O. Investigating the adherence factors of Escherichia coli at the bovine recto-anal junction. Microbiol Spectr O:e01270-24. https://doi.org/10.1128/spectrum.01270-24.

Conserved B cell signaling, activation, and differentiation in porcine jejunal and ileal Peyer’s patches despite distinct immune landscapes - (Peer Reviewed Journal)

Phenotypic and genomic comparison of three human outbreak and one cattle-associated Shiga toxin-producing Escherichia coli O157:H7 Reprint Icon - (Peer Reviewed Journal)
Peroutka-Bigus, N., Nielsen, D.W., Trachsel, J.M., Mou, K.T., Sharma, V.K., Kudva, I.T., Loving, C.L. 2024. Phenotypic and genomic comparison of three human outbreak and one cattle-associated Shiga toxin-producing Escherichia coli O157:H7. Microbiology Spectrum. https://doi.org/10.1128/spectrum.04140-23.

Butyrate receptor gene expression in myeloid cells of the lower porcine gastrointestinal tract - (Abstract Only)

Carriage and gene content of pesi-Like plasmids in Salmonella enterica serovar infantis from swine - (Abstract Only)

Identification of anti-human and mouse mAb cross-reactive to agriculture and wildlife species - (Abstract Only)

Genetic and functional diversity of Prevotella isolated from the swine intestinal tract - (Abstract Only)

Pangenome-based network analysis reveals subpopulations of Salmonella Infantis pESI-like plasmids that differ temporally and regionally - (Abstract Only)

Differential expression of virulence genes in Shiga toxin-producing Escherichia coli O157:H7 during initial colonization of human colonic epithelial and rectoanal junction cells revealed host-specific Adaptations - (Abstract Only)

The starvation-inducible Lipoprotein (Slp) plays a role in Escherichia coli O157:H7 adherence to the bovine rectoanal junction - (Abstract Only)

Assessment of commensal Escherichia coli as inhibitors of Escherichia coli O157:H7 through production of antimicrobial peptides and nutrient competition - (Abstract Only)

Comparative transcriptome analysis of Shiga toxin-producing Escherichia coli O157:H7 on bovine rectoanal junction cells and human colonic epithelial cells during initial adherence Reprint Icon - (Peer Reviewed Journal)
Edison, L.K., Kudva, I.T., Kariyawasam, S. 2023. Comparative transcriptome analysis of Shiga toxin-producing Escherichia coli O157:H7 on bovine rectoanal junction cells and human colonic epithelial cells during initial adherence. Microorganisms. 11(10). Article 2562. https://doi.org/10.3390/microorganisms11102562.

Comparative evaluation of antimicrobial activity of human granulysin, bovine and porcine NK-lysins against Shiga toxin-producing Escherichia coli O157:H7 Reprint Icon - (Peer Reviewed Journal)
Biernbaum, E.N., Dassanayake, R.P., Nicholson, E.M., Kudva, I.T. 2023. Comparative evaluation of antimicrobial activity of human granulysin, bovine and porcine NK-lysins against Shiga toxin-producing Escherichia coli O157:H7. PLOS ONE. 18(9): e0292234. https://doi.org/10.1371/journal.pone.0292234.

Impact of butyrate on short-chain fatty acid receptor expression in porcine monocytes - (Abstract Only)

Detection B cell and antibody-secreting cell populations in pigs at RNA and protein levels - (Abstract Only)

BCG induced innate training in neonatal and weaned pigs is dependent on route of administration - (Abstract Only)

Single-cell RNA sequencing reveals CD4+ macrophages are cytotoxic, phagocytic, effector cells highly responsive to B cell-derived signals in the pig small intestine - (Abstract Only)

Altered cytokine production and gene expression by porcine monocytes following neonatal inoculation with bacillus Calmette-Guerin - (Abstract Only)

From snoot to tail - A brief review of influenza virus infection and immunity in pigs Reprint Icon - (Review Article)
Ma, W., Loving, C.L., Driver, J.P. 2023. From snoot to tail - A brief review of influenza virus infection and immunity in pigs. Journal of Immunology. https://doi.org/10.4049/jimmunol.2300385.

Bovine rectoanal junction in vitro organ culture model system to study Shiga toxin-producing Escherichia coli adherence Reprint Icon - (Peer Reviewed Journal)
Kudva, I.T., Biernbaum, E.N., Cassmann, E.D., Palmer, M.V. 2023. Bovine rectoanal junction in vitro organ culture model system to study Shiga toxin-producing Escherichia coli adherence. Microorganisms. 11(5). Article 1289. https://doi.org/10.3390/microorganisms11051289.

Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils Reprint Icon - (Peer Reviewed Journal)
Herrera Uribe, J., Lim, K., Byrne, K.A., Daharsh, L., Liu, H., Corbett, R.J., Marco, G., Schroyen, M., Koltes, J.E., Loving, C.L., Tuggle, C.K. 2023. Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils. Frontiers in Genetics. 14. Article 1107462. https://doi.org/10.3389/fgene.2023.1107462.

Metagenomic detection and binning of plasmids for an improved understanding of the risk of antimicrobial resistance gene transfer events - (Abstract Only)

Non-fimbrial adhesins effect Escherichia coli O157:H7 biofilm formation on post-harvest food products - (Abstract Only)

Comparative evaluation of antimicrobial activity of human granulysin, bovine and porcine NK-lysins against Shiga toxin-producing Escherichia coli O157:H7 - (Abstract Only)

Pseudotemporal and spatial organization of B cell activation and differentiation in Peyer’s patches - (Abstract Only)

Model systems to study Shiga toxin-producing Escherichia coli interactions with the bovine gastrointestinal tract - (Abstract Only)

Pangenome analyses of bovine rectoanal junction squamous epithelial cell–specific adherence factors in E. coli - (Abstract Only)

Insights into animal carriage and pathogen surveillance in Latin America: The case of STEC and APEC Reprint Icon - (Book / Chapter)
Galarce, N., Sanchez, F., Kudva, I., Biernbaum, E.N., Knobl, T., Saidenberg, A.B. 2023. Insights into animal carriage and pathogen surveillance in Latin America: The case of STEC and APEC. In: Torres, A.G. editor. Trending Topics in Escherichia coli Research: The Latin American Perspective 2nd Edition, Springer, Chapter. p.149-175. https://doi.org/10.1007/978-3-031-29882-0_7.

Buffered peptone water promotes the transfer of antimicrobial resistance genes to Salmonella in swine cecal samples - (Abstract Only)

Short transportation did not impact circulating cortisol levels or leukocyte abundance in cattle - (Abstract Only)

Expression of short-chain fatty acid receptors and transporters in the porcine gastrointestinal tract - (Abstract Only)

Regional specialization of intraepithelial T cells and microbiota in the pig intestinal tract - (Abstract Only)

Annotating cell transcriptomes in four immune tissues to establish a porcine single-cell Immune Atlas - (Abstract Only)

Improving blood phenomics: ISU station report - (Abstract Only)

3’mRNA-Seq analysis of the effects of weaning and influenza infection on gene expression in whole blood of pigs - (Abstract Only)

Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils - (Abstract Only)

Characterization and applications of advanced regulatory element annotation in circulating porcine immune cells - (Abstract Only)

Definition of regulatory elements and transcription factors controlling immune cell gene expression at single cell resolution using single cell ATAC-Seq - (Abstract Only)

Effect of dietary ß-glucan on intestinal microbiota diversity and Salmonella vaccine immunogenicity and efficacy in pigs Reprint Icon - (Peer Reviewed Journal)
Loving, C.L., Bearson, S.M., Bearson, B.L., Kerr, B.J., Kiros, T.G., Shippy, D.C., Trachsel, J.M. 2022. Effect of dietary ß-glucan on intestinal microbiota diversity and Salmonella vaccine immunogenicity and efficacy in pigs. Veterinary Microbiology. 278. Article 109648. https://doi.org/10.1016/j.vetmic.2022.109648.

Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity Reprint Icon - (Literature Review)
Wiarda, J.E., Loving, C.L. 2022. Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity. Frontiers in Immunology. 13. Article 104708. https://doi.org/10.3389/fimmu.2022.1048708.

Phenotypic and genomic comparison of human outbreak and cattle-associated Escherichia coli O157:H7 - (Abstract Only)

Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs Reprint Icon - (Peer Reviewed Journal)
Wiarda, J.E., Watkins, H.R., Gabler, N.K., Anderson, C.L., Loving, C.L. 2023. Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs. Developmental and Comparative Immunology. 139. Article 104590. https://doi.org/10.1016/j.dci.2022.104590.

Regional epithelial cell diversity in the small intestine of pigs Reprint Icon - (Peer Reviewed Journal)
Wiarda, J.E., Becker, S.R., Sivasankaran, S.K., Loving, C.L. 2022. Regional epithelial cell diversity in the small intestine of pigs. Journal of Animal Science. 101. Article eskac318. https://doi.org/10.1093/jas/skac318.

Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells Reprint Icon - (Peer Reviewed Journal)
Wiarda, J.E., Trachsel, J.M., Sivasankaran, S.K., Tuggle, C.K., Loving, C.L. 2022. Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells. Life Science Alliance. 5(10). Article e202201442. https://doi.org/10.26508/lsa.202201442.

Assessment of DNA methylation in porcine immune cells reveals novel regulatory elements associated with cell-specific gene expression and immune capacity traits Reprint Icon - (Peer Reviewed Journal)
Corbett, R.J., Luttmann, A.M., Herrera-Uribe, J., Liu, H., Raney, N.E., Grabowski, J.M., Loving, C.L., Tuggle, C.K., Ernst, C.W. 2022. Assessment of DNA methylation in porcine immune cells reveals novel regulatory elements associated with cell-specific gene expression and immune capacity traits. Biomed Central (BMC) Genomics. 23(1). Article 575. https://doi.org/10.1186/s12864-022-08773-5.

Integration of epigenomic and transcriptomic data to identify regulatory elements and networks controlling immune cell-type gene expression in the pig - (Abstract Only)

Diversity of Alternative Splicing in Porcine Peripheral Blood Immune Cells - (Abstract Only)

A Bovine Rectoanal Junction-In vitro Organ Culture Model System to Study Shiga Toxin-Producing Escherichia coli Adherence - (Abstract Only)

Intravenous BCG induction of innate memory in young pigs - (Abstract Only)

Integrative Profiling of Gene Expression and Chromatin Accessibility Elucidates Specific Transcriptional Networks in Porcine Neutrophils - (Abstract Only)

The impact of carbadox on the swine intestinal microbiota and intraepithelial T cell populations post-weaning - (Abstract Only)

Converse trends with adaptive and innate immune responses following intravenous BCG inoculation in pigs - (Abstract Only)

AB5 Enterotoxin-Mediated Pathogenesis: Perspectives gleaned from Shiga toxins Reprint Icon - (Peer Reviewed Journal)
Biernbaum, E.N., Kudva, I.T. 2022. AB5 Enterotoxin-Mediated Pathogenesis: Perspectives gleaned from Shiga toxins. Toxins. 14(1). Article 62. https://doi.org/10.3390/toxins14010062.

Characterization of Two Novel Butyrate-Producing Species Isolated From Swine Feces - (Abstract Only)

Escherichia coli O157 differentially express proteins with a potential role in bacterial adaptation and survival in vivo in the rumen of cattle - (Abstract Only)
Kudva, I.T., Trachsel, J.M., Biernbaum, E.N., Lippolis, J.D. 2021. Escherichia coli O157 differentially express proteins with a potential role in bacterial adaptation and survival in vivo in the rumen of cattle. Meeting Abstract. https://www.abstractsonline.com/pp8/#!/9286/presentation/12063.