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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #310205
Title: Dietary modulators of statin efficacy in cardiovascular disease and cognition

Author
item WANG, HUIFEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item BLUMBERG, JEFFREY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item CHEN, C-Y OLIVER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item CHOI, SANG-WOON - Cha University
item CORCORAN, MICHAEL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item HARRIS, SUSAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item JACQUES, PAUL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item KRISTO, ALEKSANDRA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Lai, Chao Qiang
item LAMON-FAVA, STEFANI - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MATTHAN, NIRUPA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MCKAY, DIANE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MEYDANI, MOHSEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Parnell, Laurence
item PROKOPY, MAX - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SCOTT, TAMMY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LICHTENSTEIN, ALICE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Molecular Aspects of Medicine
Publication Type: Review Article
Publication Acceptance Date: 4/14/2014
Publication Date: 5/9/2014
Citation: Wang, H., Blumberg, J.B., Chen, C., Choi, S., Corcoran, M.P., Harris, S.S., Jacques, P.F., Kristo, A.S., Lai, C., Lamon-Fava, S., Matthan, N.R., Mckay, D.L., Meydani, M., Parnell, L.D., Prokopy, M.P., Scott, T.M., Lichtenstein, A.H. 2014. Dietary modulators of statin efficacy in cardiovascular disease and cognition. Molecular Aspects of Medicine. 38:1-53.

Interpretive Summary:

Technical Abstract: Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and other developed countries, and is fast growing in developing countries, particularly as life expectancy in all parts of the world increases. Current recommendations for the prevention of cardiovascular disease issued jointly from the American Academy of Cardiology and American Heart Association emphasize that lifestyle modification should be incorporated into any treatment plan, including those on statin drugs. However, there is a dearth of data on the interaction between diet and statins with respect to additive, complementary or antagonistic effects. This review collates the available data on the interaction of statins and dietary patterns, cognition, genetics and individual nutrients, including vitamin D, niacin, omega-3 fatty acids, fiber, phytochemicals (polyphenols and stanols) and alcohol. Of note, although the available data is summarized, the scope is limited, conflicting and disparate. In some cases it is likely there is unrecognized synergism. Virtually no data are available describing the interactions of statins with dietary components or dietary pattern in subgroups of the population, particularly those who may benefit most were positive effects identified. Hence, it is virtually impossible to draw any firm conclusions at this time. Nevertheless, this area is important because were the effects of statins and diet additive or synergistic harnessing the effect could potentially lead to the use of a lower intensity statin or dose.