A new approach to the treatment of acute infection diseases with antibiotic-pectin formulae

Authors: MUHIDINOV, ZAYNIDDIN - Chemistry Institute Of Tajikistan Academy Of Science; BOBOKALONOV, JAMSHED - Chemistry Institute Of Tajikistan Academy Of Science; KIMATOV, RAHIMJON - Avicenna Tajik Medical University; RAHMONOV, ERKIN - Avicenna Tajik Medical University; KOMILOVA, GULNORA - Avicenna Tajik Medical University; SHEROVA, ZAMIRA - Chemistry Institute Of Tajikistan Academy Of Science; Liu, Linshu

Submitted to: The Journal of Infection in Developing Countries
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/30/2023
Publication Date: 3/31/2024
Citation: Muhidinov, Z., Bobokalonov, J., Kimatov, R., Rahmonov, E., Komilova, G., Sherova, Z., Liu, L.S. 2024. A new approach to the treatment of acute infection diseases with antibiotic-pectin formulae. The Journal of Infection in Developing Countries. 18(3):407-419.

Interpretive Summary: Intestinal infections are a significant health issue, and antibiotics still play an important role in treating severe diarrheal or acute intestinal infections, such as amoebic dysentery, caused by a parasite, and bacillary dysentery, caused by bacteria. Antimicrobial resistance threatens to weaken the effectiveness of the current antibiotic treatments and there is no guarantee that new antibiotics under development would be as effective as the ones they replace. Thus, it would be worthwhile to attempt to preserve the efficacy of the current antibiotics. In this study, the impact of apple pectin when used in combination with antibiotics was examined. Patients suffering from either dysentery were treated with traditional antibiotics therapy and a new formula containing the antibiotics with low- and high-methoxylated apple pectin, in clinical trials over the period from 1998 to 2013, at the Infectious Disease Hospital, Dushanbe, Tajikistan. Using the antibiotic-pectin formulae (APF) significantly reduced the severity of both types of dysentery and allowed patients to recover faster than conventional treatments, with a reduction in the patient's stay in the hospital by 3.0 ± 1.0 days. The findings demonstrated that APF helped to maintain a constant concentration of the antibiotic in the blood and feces thereby accelerating patient recovery, and possibly increasing the bioavailability and the potency of the antibiotic.

Technical Abstract: Introduction. Intestinal infections are a significant health issue, and antibiotics still play an important role in treating acute intestinal infections. The literature evidence shows that the excessive use of antibiotics has created many threats to human health. This work aimed to study the impact of apple pectin in combination with antibiotics on the treatment of patients with amebiasis and dysentery. Methodology. The block randomized treatment of patients suffering acute intestinal diseases (amebiasis and dysentery) with traditional antibiotics therapy and new formula containing antibiotics with low methoxylated and high methoxylated apple pectin, including four clinical trials have been performed at the Infectious Disease Hospital in a long period from 1998 until 2013. Results. The study demonstrated that using the antibiotic-pectin formulae (APF) significantly reduced the severity of acute intestinal infection diseases and allowed patients to recover faster than conventional treatment. The result is a reduction in the patient’s stay in the hospital by 3.0 ± 1.0 days. The clinical trial findings demonstrated that applying APF in intestinal infection diseases helps maintain a constant concentration of the antibiotic in the blood and feces and accelerates the clinical recovery of patients. Conclusion. It was concluded that using pectin with antibiotics effectively could improve clinical outcomes in patients with acute infectious diseases. The research on elucidating the mechanisms of pectin digestion in the colon, polyphenol content, and its role in dysbiosis recovery, are considered.