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Gisselle Medina
Foreign Animal Disease Research
RESEARCH SCIENTIST

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Projects
Agricultural Research Service - American Type Culture Collection Biological Repository Partnership
Cooperative Agreement (A)
  Accession Number: 440496
Intervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine
In-House Appropriated (D)
  Accession Number: 441308
Development of a Novel Epitope-based Vaccine Candidate for FMDV
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444597
Comprehensive Mapping of Livestock B Cell Receptor Repertoire Using Single-cell Sequencing to Enhance Vaccine Development
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444639
Proteomic Analysis and Species-Specific Immune Responses in Livestock Vaccination Strategies
Non-Assistance Cooperative Agreement (S)
  Accession Number: 445994
Evaluating a Self-Boosting Vaccine Delivery Platform Using Ad5-FMD
Non-Assistance Cooperative Agreement (S)
  Accession Number: 446668
Generation of Replication Competent Adenovirus Type 5 Foot-and-Mouth Disease Vaccine with Increased Efficacy
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438042

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Ra) Reprint Icon - (Peer Reviewed Journal)
Dassanayake, R.P., Menghwar, H., Bickel, K.A., Holthausen, D.J., Ma, H., Segunda, F., Rodriguez-Calzada, M., Medina, G.N., Attreed, S.E., Falkenberg, S.M., Kanipe, C.R., Sacco, R.E., De Los Santos, T.B., Casas, E. 2024. Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Ra). Frontiers in Immunology. 15. Article 1441908. https://doi.org/10.3389/fimmu.2024.1441908.
Parallel single-b cell transcriptomics to elucidate swine b-cell repertoire - (Peer Reviewed Journal)
Prophylactic treatment with PEGylated bovine FN-lambda3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle Reprint Icon - (Peer Reviewed Journal)
Attreed, S.E., Silva, C.M., Rodriguez-Calzada, M., Mogulothu, A., Abbott, S.T., Azzinaro, P.A., Canning, P., Skidmore, L., Nelson, J., Knudsen, N., Medina, G.N., De Los Santos, T., Diaz-San Segundo, F. 2024. Prophylactic treatment with PEGylated bovine FN-lambda3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle. Frontiers in Microbiology. 15. https://doi.org/10.3389/fmicb.2024.1360397.
Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus Reprint Icon - (Peer Reviewed Journal)
Velazquez Salinas, L., Medina, G.N., Valdez, F., Collinson, S., Zarate, S., Zhu, J.J., Rodriguez, L.L. 2023. Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus. Pathogens. 12(7). Article 896. https://doi.org/10.3390/pathogens12070896.
Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains Reprint Icon - (Abstract Only)
Medina, G.N., Spinard Iii, E.J., Azzinaro, P.A., Rodriguez-Calzada, M., Rieder, A.E., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains. Meeting Abstract. https://doi.org/10.3390/v15061332.
Deoptimization of FMDV P1 region results in robust serotype-independent viral attenuation Reprint Icon - (Peer Reviewed Journal)
Medina, G.N., Diaz-San Segundo, F., Spinard III, E.J., Azzinaro, P.A., Rodriguez-Calzada, M., Gutkoska, J.R., Kloc, A., Rieder, A.E., Mueller, S., De Los Santos, T.B. 2023. Deoptimization of FMDV P1 region results in robust serotype-independent viral attenuation. Viruses. 15(6). https://doi.org/10.3390/v15061332.
Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD Reprint Icon - (Proceedings)
Medina, G.N., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD. Global Foot-and Mouth Disease Research Alliance (GFRA). https://doi.org/10.3390/v15061332.
Evaluation of potential in vitro recombination events in codon deoptimized FMDV strains Reprint Icon - (Peer Reviewed Journal)
Spinard III, E.J., Fish, I., Azzinaro, P.A., Rodriguez-Calzada, M., Hartwig, E.J., Smoliga, G.R., Arzt, J., De Los Santos, T.B., Medina, G.N. 2022. Evaluation of potential in vitro recombination events in codon deoptimized FMDV strains. Viruses. 15(3). https://doi.org/10.3390/v15030670.
Evaluation of potential recombination events in codon deoptimized FMDV strains Reprint Icon - (Abstract Only)
Spinard, E., Fish, I., Azzinaro, P.A., Hartwig, E.J., Smoliga, G.R., Mogulothu, A., Rodriguez-Calzada, M., Arzt, J., De Los Santos, T.B., Medina, G.N. 2023. Evaluation of potential recombination events in codon deoptimized FMDV strains. Meeting Abstract. https://doi.org/10.3390/v15030670.
Mutation of FMDV Lpro H138 reside outside substrate binding domain drives viral attenuation in vitro and in swine Reprint Icon - (Peer Reviewed Journal)
Azzinaro, P.A., Medina, G.N., Rai, D., Ramirez Medina, E., Spinard Iii, E.J., Zhu, J.J., Rieder, A.E., De Los Santos, T.B., Diaz San Segundo, F.C. 2022. Mutation of FMDV Lpro H138 reside outside substrate binding domain drives viral attenuation in vitro and in swine. Frontiers in Veterinary Science. https://www.frontiersin.org/articles/10.3389/fvets.2022.1028077/full.
Mutation of FMDV Lpro residues outside substrate binding domain drives viral attenuation Reprint Icon - (Abstract Only)
Diaz San Segundo, F.C., Azzinaro, P.A., Zhu, J.J., Medina, G.N., De Los Santos, T.B. 2022. Mutation of FMDV Lpro residues outside substrate binding domain drives viral attenuation. Meeting Abstract. https://doi.org/10.3389/fvets.2022.1028077.
Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle Reprint Icon - (Peer Reviewed Journal)
Fish, I., Bertram, M.R., Stenfeldt, C., Smoliga, G.R., Hartwig, E.J., Holinka-Patterson, L.G., De Los Santos, T.B., Spinard III, E.J., Medina, G.N., Arzt, J., Azzinaro, P.A. 2022. Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle. Pathogens. https://doi.org/10.3390/pathogens11060644.
Pegylated Interferon vs Standard Interferon: a promising biotherapeutic platform to get strong and long-lasting antiviral activity against FMDV Reprint Icon - (Proceedings)
Diaz San Segundo, F.C., Medina, G.N., De Los Santos, T.B. 2021. Pegylated Interferon vs Standard Interferon: a promising biotherapeutic platform to get strong and long-lasting antiviral activity against FMDV. Global Foot-and Mouth Disease Research Alliance (GFRA). https://doi.org//10.3389/fmicb.2021.668890.
FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation Reprint Icon - (Peer Reviewed Journal)
Visser, L.J., Medina, G.N., Rabouw, H.H., De Groot, R.J., Langereis, M.A., De los Santos, T.B., Van Kuppeveld, F.J. 2018. FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology. https://doi.org/10.1128/JVI.00922-18.
Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics - (Book / Chapter)
Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle - (Peer Reviewed Journal)
Montiel, N., Medina, G.N., Sturza, D., Diaz-San Segundo, F., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle. Clinical and Vaccine Immunology. 23:125-136. doi: 10.1128/CVI.00426-15.
Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response - (Peer Reviewed Journal)
Diaz-San Segundo, F., Koster, M.J., Ramirez-Medina, E., Medina, G.N., Velazquez-Salinas, L., Grubman, M.J., De Los Santos, T.B. 2015. Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response. Journal of Virology. 90:1298-1310. doi:10.1128/JVI.02167-15.
Animal health: foot-and-mouth disease - (Book / Chapter)
Diaz San Segundo, F.C., Medina, G.N., Grubman, M.J., De Los Santos, T.B. 2014. Animal health: Foot-and-Mouth Disease. In: Van Alfen, N.K., editor. Encyclopedia of Agriculture and Food Systems. 2nd edition. United States of America: Elsevier/Academic Press. p. 327-345.