Research Project: Discovery and Development of Natural Products for Pharmaceutical and Agrochemical Applications II

Location: Natural Products Utilization Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Identification of antifungal bisphosphocholines from medicinal Gentiana species - (Peer Reviewed Journal)
Ren, S., Deng, K., Qiu, S., Wang, M., Avula, B., Tripathi, S.K., Jacob, M.R., Gong, L., Wang, W., Khan, I.A., Li, X. 2020. Identification of antifungal Bisphosphocholines from medicinal Gentiana species. Journal of Natural Products. 2020, 83, 10, 3207–3211. https://doi.org/10.1021/acs.jnatprod.0c00584.

Chemical profiling and characterization of phenolic acids, flavonoids, terpene glycosides from Vangueria agrestis using ultra-high-performance liquid chromatography/ion mobility quadrupole time-of-flight mass spectrometry and - (Peer Reviewed Journal)
Avula, B., Bae, J., Wang, Y., Wang, M., Osman, A.G., Smith, K., Yuk, J., Ali, Z., Plumb, R., Isaac, G., Khan, I.A. 2020. Chemical profiling and characterization of phenolic acids, flavonoids, terpene glycosides from Vangueria agrestis using ultra-high-performance liquid chromatography/ion mobility quadrupole time-of-flight mass spectrometry and metabolomics approach. Biomedical Chromatography. https://doi.org/10.1002/bmc.4840.

Chemosystematically valuable triterpenoid saponins from Glandularia x hybrida - (Peer Reviewed Journal)
Mohamed, N.M., Makboul, M.A., Farag, S.F., Wang, Y., Mohamed, S.M., Ross, S.A. 2020. Chemosystematicaly valuable triterpenoid saponins from Glandularia x hybrida. Phytochemistry. 175:112367. https://doi.org/10.1016/j.phytochem.2020.112367.

Characterization, quantification and quality assessment of Avocado (Persea americana Mill.) oils - (Peer Reviewed Journal)
Wang, M., Yu, P., Chittiboyina, A.G., Chen, D., Zhao, J., Avula, B., Wang, Y., Khan, I.A. 2020. Characterization, quantification and quality assessment of Avocado (Persea americana Mill.) oils. Molecules. 25(6):1453. https://doi.org/10.3390/molecules25061453.

Evaluation of the hepatotoxic potential of Tinospora crispa and its isolated borapetosides B, C and F in a murine model - (Peer Reviewed Journal)
Parveen, A., Maqbool, M., Wang, Y., Ali, Z., Khan, I.A., Ashfaq, M. 2020. Evaluation of the hepatotoxic potential of Tinospora crispa and its isolated borapetosides B, C and F in a murine model. Planta Medica. 86(07):489-495. https://doi.org/10.1055/a-1127-7503.

Isolation of chemical compounds and essential oil from Agrimonia asiatica Juz. and their antimicrobial and antiplasmodial activities - (Peer Reviewed Journal)
Kozykeyeva, R.A., Datkhayev, U.M., Srivedavyasasri, R., Ajayi, T.O., Patsayev, A.K., Kozykeyeva, R.A., Ross, S.A. 2020. Isolation of chemical compounds and essential oil from Agrimonia asiatica Juz. and their antimicrobial and antiplasmodial activities. The Scientific World. https://doi.org/10.1155/2020/7821310.

A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products - (Peer Reviewed Journal)
Avula, B., Parveen, I., Zhao, J., Wang, M., Techen, N., Wang, Y., Riaz, M., Bae, J., Shami, A.A., Chittiboyina, A.G., Khan, I.A., Sharp, J.S. 2021. A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products. Journal of Dietary Supplement. https://doi.org/10.1080/19390211.2021.1897724.

Chemometrics-assisted identification of anti-inflammatory compounds from the green alga Klebsormidium flaccidum var. zivo (KALGAE™) - (Peer Reviewed Journal)
Qiu, S., Khan, S.I., Wang, M., Zhao, J., Ren, S., Khan, I.A., Steffek, A., Pfund, W.P., Li, X. 2020. Chemometrics-assisted identification of anti-inflammatory compounds from the green alga Klebsormidium flaccidum var. zivo (KALGAE™). Molecules. 25(5):1048. https://doi.org/10.3390/molecules25051048.

Norlignan glucosides from Hypoxis hemerocallidea and their potential in vitro anti-inflammatory activity via inhibition of iNOS and NF-kB - (Peer Reviewed Journal)
Zulfiqar, F., Khan, S.I., Ali, Z., Wang, Y., Ross, S.A., Vilijoen, A.M., Khan, I.A. 2020. Norlignan glucosides from Hypoxis hemerocallidea and their potential in vitro anti-inflammatory activity via inhibition of iNOS and NF-kB. Journal of Natural Products. 172:112273. https://doi.org/10.1016/j.phytochem.2020.112273.

Synthesis, structural assignments, and antiinfective activities of 3-0-benzyl-carvotacetone and 3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone - (Peer Reviewed Journal)
Masila, V.M., Ndakala, A.J., Byamukama, R., Midiwo, J.O., Kamau, R.W., Wang, M., Kumarihamy, M., Zhao, J., Heydreich, M., Muhammad, I. 2020. Synthesis, structural assignments, and antiinfective activities of 3-0-benzyl-carvotacetone and 3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone. Natural Product Research. https://doi.org/10.1080/14786419.2020.1716346.

Puupehenone, a marine sponge-derived sesquiterpene quinone, potentiates the antifungal drug Caspofungin by disrupting Hsp90 activity and the cell wall integrity pathway - (Peer Reviewed Journal)
Tripathi, S.K., Feng, Q., Liu, L., Levin, D.E., Roy, K.K., Doerksen, R.J., Baerson, S.R., Shi, X., Pan, X., Xu, W., Li, X., Clark, A.M., Agarwal, A.K. 2020. Puupehenone, a marine sponge-derived sesquiterpene quinone, potentiates the antifungal drug Caspofungin by disrupting Hsp90 activity and the cell wall integrity pathway. mSphere. 5(1):e00818-19. https://doi.org/10.1128/mSphere.00818-19.

In search for potential antidiabetic compounds from natural sources: docking, synthesis and biological screening of small molecules from Lycium spp. (Goji) - (Peer Reviewed Journal)
Yalamanchili, C., Chittiboyina, A.G., Haider, S., Vasquez, Y., Khan, S., Do Carmo, J.M., Da Silva, A.A., Pinkerton, M., Hall, J.E., Walker, L.A., Khan, I.A. 2020. In search for potential antidiabetic compounds from natural sources: docking, synthesis and biological screening of small molecules from Lycium spp. (Goji). Heliyon. 6(1):e02782. https://doi.org/10.1016/j.heliyon.2019.e02782.

Development and validation of a UHPLC-PDA-MS method for the quantitative analysis of anthraquinones in Bulbine natalensis extracts and dietary supplements - (Peer Reviewed Journal)
Bae, J., Avula, B., Wang, Y., Wang, M., Ali, Z., Viljeon, A.M., Khan, I.A. 2019. Development and validation of a UHPLC-PDA-MS method for the quantitative analysis of anthraquinones in Bulbine natalensis extracts and dietary supplements. Planta Medica. 86:144-150. https://doi.org/10.1055/a-1037-4051.

Effect of raspberry ketone on normal, obese and health-compromised obese mice: A preliminary study - (Peer Reviewed Journal)
Mir, T., Ma, G., Ali, Z., Khan, I.A., Ashfaq, M.K. 2019. Effect of raspberry ketone on normal, obese and health-compromised obese mice: A preliminary study. Journal of Dietary Supplement. https://doi.org/10.1080/19390211.2019.1674996.

Identification and charaterization of key chemical constituents in processed Gastrodia elata using UHPLC-MS/MS and chemometric methods - (Peer Reviewed Journal)
Ye, X., Wang, Y., Zhao, J., Wang, M., Avula, B., Peng, Q., Ouyang, H., Lingyun, Z., Zhang, J., Khan, I.A. 2019. Identification and charaterization of key chemical constituents in processed Gastrodia elata using UHPLC-MS/MS and chemometric methods. Journal of Analytical Methods in Chemistry. https://doi.org/10.1155/2019/4396201.

Analysis of Prenylflavonoids from aerial parts of Epimedium grandiflorum and dietary supplements using HPTLC, UHPLC-PDA and UHPLC-QToF along with chemometric tools to differentiate Epimedium species - (Peer Reviewed Journal)
Bae, J., Avula, B., Zhao, J., Raman, V., Wang, Y., Wang, M., Zulfiqar, F., Feng, W., Park, J., Abe, N., Ali, Z., Khan, I.A. 2019. Analysis of Prenylflavonoids from aerial parts of Epimedium grandiflorum and dietary supplements using HPTLC, UHPLC-PDA and UHPLC-QToF along with chemometric tools to differentiate Epimedium species. Journal of Pharmaceutical and Biomedical Analysis. 177:112843. https://doi.org/10.1016/j.jpba.2019.112843.

FOXO signal activating alkaloids isolated from Ochrosia elliptica leaf cultivated in Egypt - (Peer Reviewed Journal)
Labib, R.M., Zulfiqar, F., Ibrahim, M.A., Balachandran, P., Zhang, J., Ross, S.A. 2019. FOXO signal activating alkaloids isolated from Ochrosia elliptica leaf cultivated in Egypt. Medicinal Chemistry Research. 28:1628-1632. https://doi.org/10.1007/s00044-019-02399-1.

Two new phytoecdysteroids from Sphenocentrum jollyanum Pierre root - (Peer Reviewed Journal)
Ajayi, T.O., Srivedavyasasri, R., Nyong, E.E., Odeniyi, M.A., Moody, J.O., Ross, S.A. 2019. Two new phytoecdysteroids from Sphenocentrum jollyanum Pierre root. Steroids. 150:108456. https://doi.org/10.1016/j.steroids.2019.108456.

Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements - (Peer Reviewed Journal)
Avula, B., Bae, J., Chittiboyina, A.G., Wang, Y., Wang, M., Khan, I.A. 2019. Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. Journal of Pharmaceutical and Biomedical Analysis. 174:305-323. https://doi.org/10.1016/j.jpba.2019.05.066.

Toxicity of Kadsura coccinea (Lem.) A. C. Sm. essential oil to the Bed Bug, Cimex lectularius L. (Hemiptera: Cimicidae) - (Peer Reviewed Journal)
Rehman, J.U., Wang, M., Yang, Y., Liu, Y., Li, B., Qin, Y., Wang, W., Chittiboyina, A.G., Khan, I.A. 2019. Toxicity of Kadsura coccinea (Lem.) A. C. Sm. essential oil to the Bed Bug, Cimex lectularius L. (Hemiptera: Cimicidae). Journal of Insect Science. 10(162):1-11. https://doi.org/10.3390/insects10060162.

Anthraquinone-based specialized metabolites from rhizomes of Bulbine natalensis - (Peer Reviewed Journal)
Bae, J., Ali, Z., Wang, Y., Chittiboyina, A.G., Zaki, A.A., Viljeon, A.M., Khan, I.A. 2019. Anthraquinone-based specialized metabolites from rhizomes of Bulbine natalensis. Journal of Natural Products. 82:1893-1901. https://doi.org/10.1021/acs.jnatprod.9b00187.

Quantitative determination and pharmacokinetic study of fusaricidin A in mice plasma and tissues using ultra-high performance liquid chromatography-tandem mass spectrometry - (Peer Reviewed Journal)
Haron, M.H., Avula, B., Qui, S., Li, X., Ashfaq, M.K., Bae, J., Guan, S., Hinchee, M., Khan, I.A., Khan, S.I. 2019. Quantitative determination and pharmacokinetic study of fusaricidin A in mice plasma and tissues using ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 170:187-192. https://doi.org/10.1016/j.jpba.2019.03.042.

Effect of African potato (Hypoxis hemerocallidea) extracts and its constituents on PXR and CYP450 Enzymes - (Peer Reviewed Journal)
Haron, M.H., Dale, O.R., Zulfiqar, F., Wang, Y., Chittiboyina, A.G., Khan, I.A., Khan, S.I. 2019. Effect of African potato (Hypoxis hemerocallidea) extracts and its constituents on PXR and CYP450 Enzymes. Applied In Vitro Toxicology. 5(1):26-33. https://doi.org/10.1089/aivt.2018.0022.

Pharmacokinetics and tissue distribution of Aegeline after oral administration in mice - (Peer Reviewed Journal)
Manda, V., Haron, M.H., Mir, T.M., Avula, B., Ashfaq, M.K., Haider, S., Chittiboyina, A.G., Khan, I.A., Khan, S.I. 2019. Pharmacokinetics and tissue distribution of Aegeline after oral administration in mice. Planta Medica. 85(06):491-495. https://doi.org/10.1055/a-0851-6879.

The chemical characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS - (Peer Reviewed Journal)
Wang, Y., Meng, Y., Zhai, C., Wang, M., Avula, B., Yuk, J., Smith, K.M., Isaac, G., Khan, I.A. 2019. The chemical characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS. International Journal of Molecular Sciences. 20(3):475-488. https://doi.org/10.3390/ijms20030475.

Identification of fusaricidins from the antifungal microbial strain Paenibacillus sp. MS2379 using ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry - (Peer Reviewed Journal)
Qiu, S., Avula, B., Guan, S., Ravu, R., Wang, M., Zhao, J., Khan, I.A., Hinchee, M., Li, X. 2018. Identification of fusaricidins from the antifungal microbial strain Paenibacillus sp. MS2379 using ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Journal of Chromatography A. 1586:91-100. https://doi.org/10.1016/j.chroma.2018.12.007.

Synthesis and anti-inflammatory activities of Phloroglucinol-based derivatives - (Peer Reviewed Journal)
Li, N., Khan, S.I., Qui, S., Li, X. 2018. Synthesis and anti-inflammatory activities of Phloroglucinol-based derivatives. Molecules. 23(12):3232-3240. https://doi.org/10.3390/molecules23123232.

Plant microbiome-dependent immune enhancing action of Echinacea purpurea is enhanced by soil organic matter content - (Peer Reviewed Journal)
Haron, M.H., Tyler, H.L., Chandra, S., Moraes, R.M., Jackson, C.R., Pugh, N.D., Pasco, D.S. 2019. Plant microbiome-dependent immune enhancing action of Echinacea purpurea is enhanced by soil organic matter content. Scientific Reports. 9(136):1-11. https://doi.org/10.1038/s41598-018-36907-x.

Quantification of phenolic compounds from Fadogia agrestis and dietary supplements using UHPLC-PDA-MS - (Peer Reviewed Journal)
Avula, B., Bae, J., Raman, V., Wang, Y., Fantoukh, O., Osman, A., Wang, M., Ali, Z., Khan, I.A. 2018. Quantification of phenolic compounds from Fadogia agrestis and dietary supplements using UHPLC-PDA-MS. Analytical and Bioanalytical Chemistry. 85(2):145-154. https://doi.org/10.1055/a-0715-1801.

Targeted and non-targeted analysis of annonaceous alkaloids and acetogenins from Asimina and Annona species using UHPLC-QTofF-MS - (Peer Reviewed Journal)
Avula, B., Bae, J., Wu, T., Wang, Y., Wang, M., Majrashi, T., Ali, Z., Wu, Y., Khan, I.A. 2018. Targeted and non-targeted analysis of annonaceous alkaloids and acetogenins from Asimina and Annona species using UHPLC-QTofF-MS. Journal of Pharmaceutical and Biomedical Analysis. 159:548-566. https://doi.org/10.1016/j.jpba.2018.07.030.

Application of GC/Q-ToF combined with advanced data mining and chemometric tools in the characterization and quality control of bay leaves - (Peer Reviewed Journal)
Wang, M., Raman, V., Zhao, J., Avula, B., Wang, Y., Wylie, P.L., Khan, I.A. 2018. Application of GC/Q-ToF combined with advanced data mining and chemometric tools in the characterization and quality control of bay leaves. Planta Medica. https://doi.org/10.1055/a-0585-5987.

1,5-Dimethylhexylamine (octodrine) in sports and weight loss supplements: Natural constituent or synthetic chemical? - (Peer Reviewed Journal)
Wang, M., Haider, S., Chittiboyina, A.G., Parcher, J.F., Khan, I.A. 2018. 1,5-Dimethylhexylamine (octodrine) in sports and weight loss supplements: Natural constituent or synthetic chemical? Journal of Pharmaceutical and Biomedical Analysis. 152:298-305. https://doi.org/10.1016/j.jpba.2018.02.008.

One-step, stereoselective synthesis of octahydrochromanes via the Prins reaction and their cannabinoid activities - (Peer Reviewed Journal)
Slater, S., Lasonkar, P.B., Haider, S., Alqahtani, M.J., Chittiboyina, A.G., Khan, I.A. 2018. One-step, stereoselective synthesis of octahydrochromanes via the Prins reaction and their cannabinoid activities. Tetrahedron Letters. 59:807-810. https://doi.org/10.1016/j.tetlet.2018.01.040.

Detection and quantification of phenethylamines in sports dietary supplements by NMR approach - (Peer Reviewed Journal)
Zhao, J., Wang, M., Avula, B., Khan, I.A. 2018. Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. Journal of Pharmaceutical and Biomedical Analysis. 151:347-355. https://doi.org/10.1016/j.jpba.2018.01.025.

New polyisoprenylated polycyclic phloroglucines from Clusia gundlachii - (Peer Reviewed Journal)
Zhang, J., Zhao, J., Samoylenko, V., Jain, S., Tekwani, B.L., Muhammad, I. 2018. New polyisoprenylated polycyclic phloroglucines from Clusia gundlachii. Natural Product Communications. 13(3):361-365.

Total phenolics and flavonoids content, free radical scavaging potential, and major chemical constituents of tissue culture raised Stevia rebaudiana Bertoni - (Peer Reviewed Journal)
Lata, H., Chandra, S., Avula, B., Wang, Y., Khan, S., Sagi, S., Elsohly, M.A., Khan, I.A. 2017. Total phenolics and flavonoids content, free radical scavaging potential, and major chemical constituents of tissue culture raised Stevia rebaudiana Bertoni. Journal of Tropical Agriculture. 35/1005:1014.

Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads - (Peer Reviewed Journal)
Jain, J., Jain, S., Walker, L., Tekwani, B. 2017. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. Biomed Central Pharmacology and Toxicology Journal. doi:10.1186/s40360-017-0147-4.

Evaluation of secondary metabolites from the Red Sea tunicate polyclinum constellatum - (Peer Reviewed Journal)
Raslan, A., Radwan, M., Ahmed, S., Nafady, A., Wanas, A., Babu, T., Hassanin, H., Elsohly, M. 2017. Evaluation of secondary metabolites from the Red Sea tunicate polyclinum constellatum. Pharmacy & Pharmacology International Journal. 5(3): doi:10.15406/ppij.2017.05.00123

Prenylated flavonol glycosides Epimedium grandiflorum: Cytotoxicity and evaluation against inflammation and metabolic disorders - (Peer Reviewed Journal)
Zulfiqar, F., Khan, S.I., Ross, S.A., Ali, Z., Khan, I.A. 2017. Prenylated flavonol glycosides Epimedium grandiflorum: Cytotoxicity and evaluation against inflammation and metabolic disorders. Phytochemistry Letters. 20:160-167.

Metabolic profiling of Hoodia, Chamomile, Terminalia Species and evaluation of commercial preparations using Ultra-High Performance Quadrupole Time of Flight-Mass Spectrometry - (Peer Reviewed Journal)
Avula, B., Wang, Y., Isaac, G., Yuk, J., Wrona, M., Yu, K., Khan, I.A. 2017. Metabolic profiling of Hoodia, Chamomile, Terminalia Species and evaluation of commercial preparations using Ultra-High Performance Quadrupole Time of Flight-Mass Spectrometry. Planta Medica. doi:10.1055/s-0043-109239.

Separation of cucurbitane triterpenoids from bitter melon drinks and determination of partition coefficients using vortex-assisted dispersive liquid-phase microextraction followed by UHPLC analysis - (Peer Reviewed Journal)
Hu, S., Wang, Y., Avula, B., Wang, M., Khan, I.A. 2017. Separation of cucurbitane triterpenoids from bitter melon drinks and determination of partition coefficients using vortex-assisted dispersive liquid-phase microextraction followed by UHPLC analysis. Journal of Separation Science. 40(10):2238-2245.

Proteoform-specific protein binding of small molecules in complex matrices - (Peer Reviewed Journal)
Gil, G., Mao, P., Avula, B., Ali, Z., Chittiboyina, A.G., Khan, I.A., Walker, L.A., Wang, D. 2017. Proteoform-specific protein binding of small molecules in complex matrices. ACS Chemical Biology. 12:389-397.

Eleutherococcus senticosus (Araliaceae) leaf morpho-anatomy, essential oil composition and its biological activity against Aedes aegypti (Diptera: Culicidae) - (Peer Reviewed Journal)
Zhai, C., Wang, M., Raman, V., Rehman, J.U., Meng, Y., Zhao, J., Avula, B., Wang, Y., Tian, Z., Khan, I.A. 2016. Eleutherococcus senticosus (Araliaceae) leaf morpho-anatomy, essential oil composition and its biological activity against Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology. 54(3):658-669. doi:10.1093/jme/tjw221.

Toxicity and synergistic activities of Chalcones against Aedes aegypti (Diptera: Culicidae) and Drosophila melanogaster (Diptera: Drosophilidae) - (Peer Reviewed Journal)
Gross, A., Tabanca, N., Islam, R., Ali, A., Khan, I.A., Kaplancikli, Z.A., Altintop, M.D., Ozdemir, A., Bloomquist, J.R. 2017. Toxicity and synergistic activities of Chalcones against Aedes aegypti (Diptera: Culicidae) and Drosophila melanogaster (Diptera: Drosophilidae). Journal of Medical Entomology. 54(2):382-386.

Both phenolic and non-phenolic green tea fractions inhibit migration of cancer cells - (Peer Reviewed Journal)
Seo, E., Wu, C., Ali, Z., Wang, Y., Khan, S.I., Walker, L.A., Khan, I.A., Efferth, T. 2016. Both phenolic and non-phenolic green tea fractions inhibit migration of cancer cells. Frontiers in Pharmacology. 7(398):1-16.

Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms - (Peer Reviewed Journal)
Tyler, H.L., Haron, M.H., Pugh, N.D., Zhang, J., Jackson, C.R., Pasco, D.S. 2016. Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms. Food & Function. 7:4213-4221.

Quantification of mesembrine and mesembrenone in mouse plasma using UHPLC-QToF-MS: Application to a pharmacokinetic study - (Peer Reviewed Journal)
Manda, V.K., Avula, B., Ashfaq, K., Abe, N., Khan, I.A., Khan, S.I. 2016. Quantification of mesembrine and mesembrenone in mouse plasma using UHPLC-QToF-MS: Application to a pharmacokinetic study. Biomedical Chromatography. doi:10.1002/bmc.3815.

What happens after the activation of ascaridole? Reactive compounds and their implications for skin sensitization - (Peer Reviewed Journal)
Chittiboyina, A.G., Avonto, C., Khan, I.A. 2016. What happens after the activation of ascaridole? Reactive compounds and their implications for skin sensitization. Chemical Research in Toxicology. 29:1488-1492. doi:10.1021/acs.chemrestox.6b00157.

Utilizing Ayurvedic literature for the identification of novel phytochemical inhibitors of botulinum neurotoxin A - (Peer Reviewed Journal)
Yalamanchili, C., Manda, V.K., Chittiboyina, A.G., Guernieri, R.L., Harrell, Jr., W.A., Webb, R.P., Smith, L.A., Khan, I.A. 2016. Utilizing Ayurvedic literature for the identification of novel phytochemical inhibitors of botulinum neurotoxin A. Journal of Ethnopharmacology. 197:211-217.

Studies on the floral anatomy and scent chemistry of Titan Arum (Amorphophallus titanum, Araceae) - (Peer Reviewed Journal)
Raman, V., Tabanca, N., Demirci, B., Khan, I.A. 2017. Studies on the floral anatomy and scent chemistry of Titan Arum (Amorphophallus titanum, Araceae). Turkish Journal of Botany. 41:63-74.

Chemical composition and biting deterrent activity of essential oil of Tagetes patula (Marigold) against Aedes aegypti - (Peer Reviewed Journal)
Ali, A., Tabanca, N., Amin, E., Demirci, B., Khan, I.A. 2016. Chemical composition and biting deterrent activity of essential oil of Tagetes patula (Marigold) against Aedes aegypti. Journal of Medical Entomology. 11(10):1535-1538. https://doi.org/10.1177/1934578X1601101028.

In chemico evaluation of tea tree essential oils as skin sensitizers: Impact of the chemical composition on aging and generation of reactive species - (Peer Reviewed Journal)
Avonto, C., Chittiboyina, A.G., Wang, M., Vasquez, Y., Rua, D., Khan, I.A. 2016. In chemico evaluation of tea tree essential oils as skin sensitizers: Impact of the chemical composition on aging and generation of reactive species. Chemical Research in Toxicology. 29:1108-1117.

Gene expression profiling and pathway analysis in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin - (Peer Reviewed Journal)
Aumsuwan, P., Khan, S.I., Khan, I.A., Walker, L.A., Dasmahapatra, A.K. 2016. Gene expression profiling and pathway analysis in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin. Data in Brief. (2016)272-279.

Screening North American plant extracts in vitro against Trypanosoma brucei, the causative agent for Human African Trypanosomiasis - (Peer Reviewed Journal)
Jain, S., Jacob, M., Walker, L., Tekwani, B. 2016. Screening North American plant extracts in vitro against Trypanosoma brucei, the causative agent for Human African Trypanosomiasis. BMC Complementary and Alternative Medicine. 16(1):131. doi: 10.1186/s12906-016-1122-0.

Meroterpenoids with antiproliferative activity from a Hawaiian-plant associated fungus Peyronellaea coffeae-arabicae FT238 - (Peer Reviewed Journal)
Li, C., Ren, G., Yang, B., Miklossy, G., Turkson, J., Fei, P., Ding, Y., Walker, L.A., Cao, S. 2016. Meroterpenoids with antiproliferative activity from a Hawaiian-plant associated fungus Peyronellaea coffeae-arabicae FT238. Organic Letters. 18(10):2335-8. doi:10.1021/acs.orglett.6b00685.

Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical - (Peer Reviewed Journal)
Haron, M.H., Tyler, H.L., Pugh, N.D., Moraes, R.M., Maddox, V.L., Jackson, C.R., Pasco, D.S. 2016. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical. Planta Medica. 89(4-5):451-62. DOI: 10.1007/s11103-015-0381-3

Liquid chromatography-electrospray ionization mass spectrometry analysis of limonoids and flavanois in seeds of grapefruits, other citrus species, and dietary supplements - (Peer Reviewed Journal)
Avula, B., Sagi, S.J., Wang, Y., Wang, M., Garner, S., Manthey, J.A., Khan, I.A. 2016. Liquid chromatography-electrospray ionization mass spectrometry analysis of limonoids and flavanois in seeds of grapefruits, other citrus species, and dietary supplements. Planta Medica. 82:1058-1069. https://doi.org/10.1055/s-0042-107598.

Concurrent and supercritical fluid chromatographic analysis of Terpene Lactones and ginkolic acids in Ginko biloba - (Peer Reviewed Journal)
Wang, M., Carrell, E., Chittiboyina, A.G., Avula, B., Wang, Y., Zhao, J., Parcher, J.F., Khan, I.A. 2016. Concurrent and supercritical fluid chromatographic analysis of Terpene Lactones and ginkolic acids in Ginko biloba. Analytical and Bioanalytical Chemistry. 408(17):4649-4660. doi: 10.1007/s00216-016-9544-6.

Ermophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp.FT087 - (Peer Reviewed Journal)
Li, C., Ding, Y., Yang, B., Hoffman, N., Yin, H., Mahmud, T., Turkson, J., Cao, S. 2016. Ermophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp.FT087. Phytochemistry. 126:41-6. doi:doi:10.1016/j.phytochem.2016.03.005.

Methemoglobinemia hemotoxicity of some antimalarial 8-aminoquinoline analogues and their hydroxylated derivatives: density functional theory computation of ionization potentials - (Peer Reviewed Journal)
Ding, Y., Liu, H., Tekwani, B.L., Nanayakkara, N., Khan, I.A., Walker, L.A., Doerksen, R.J. 2016. Methemoglobinemia hemotoxicity of some antimalarial 8-aminoquinoline analogues and their hydroxylated derivatives: density functional theory computation of ionization potentials. Chemical Research in Toxicology. http://dx.doi.org/acs.orglett.6b00063.

Modulation of CYPs, P-gp, and PXR by Eschscholzia californica (California poppy) and its alkaloids - (Peer Reviewed Journal)
Manda, V.K., Ibrahim, M.A., Dale, O.R., Kumarihamy, M., Cutler, S.J., Khan, I.A., Walker, L.A., Muhammad, I., Khan, S.I. 2016. Modulation of CYPs, P-gp, and PXR by Eschscholzia californica (California poppy) and its alkaloids. Planta Medica. 82:551-558. DOI http://dx.doi.org/10.1055/s-0042-103689

Simultaneous determination of aegeline and six coumarins from different parts of the plant Aegle marmelos using UHPLC-PDA-MS and chiral separation of aegeline using HPLC-ToF-MS - (Peer Reviewed Journal)
Avula, B., Chittiboyina, A.G., Wang, Y., Sagi, S.J., Raman, V., Wang, M., Khan, I.A. 2016. Simultaneous determination of aegeline and six coumarins from different parts of the plant Aegle marmelos using UHPLC-PDA-MS and chiral separation of aegeline using HPLC-ToF-MS . Planta Medica. 82(06):580-588.

Tandem Mass Spectrometry for Structural Identification of Sesquiterpene alkaloids from the stems of dendrobium nobile using LC-QToF3 - (Peer Reviewed Journal)
Wang, Y., Avula, B., Abe, N., Wei, F., Wang, M., Ma, S., Ali, Z., Elsohly, M.A., Khan, I.A. 2016. Tandem Mass Spectrometry for Structural Identification of Sesquiterpene alkaloids from the stems of dendrobium nobile using LC-QToF3. Planta Medica. 82(7):662-70.

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro - (Peer Reviewed Journal)
Aumsuawan, P., Khan, S.I., Khan, I.A., Ali, Z., Avula, B., Walker, L.A., Shariat-Madar, Z., Helferich, W.G., Katzenellenbogen, B.S., Dasmahapatra, A.K. 2016. The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro. Archives Of Biochemistry and Biophysics. 591:98-110. doi: 10.1016/j.abb.2015.12.001.

Polyhouse cultivation of invitro raised elite Stevia rebaudiana Bertoni: An assessment of biochemical and photosynthetic characteristics - (Peer Reviewed Journal)
Lata, H., Chandra, S., Wang, Y., Elsohly, M.A., Khan, I.A. 2015. Polyhouse cultivation of invitro raised elite Stevia rebaudiana Bertoni: An assessment of biochemical and photosynthetic characteristics. Journal of Tropical Agriculture. 33(4):1-7. 2015

Clinically relevant pharmacokinetic herb-drug interactions in antiretroviral therapy - (Peer Reviewed Journal)
Fasinu, P.S., Gurley, B.J., Walker, L.A. 2015. Clinically relevant pharmacokinetic herb-drug interactions in antiretroviral therapy. Current Drug Metabolism. 17(1):52-64.

Potent antitrypanosomal triterpenoid saponins from Mussaenda luteola - (Peer Reviewed Journal)
Mohamed, S.M., Bachkeet, E.Y., Bayoumi, S.A., Jain, S., Cutler, S., Tekwani, B.L., Ross, S.A. 2015. Potent antitrypanosomal triterpenoid saponins from Mussaenda luteola. Fitoterapia. 107:114-121.

Modulation of DNA methylation machineries in Japanese rice fish (Oryzias latipes) embryogenesis by ethanol and 5-azacytidine - (Peer Reviewed Journal)
Dasmahapatra, A.K., Khan, I.A. 2015. Modulation of DNA methylation machineries in Japanese rice fish (Oryzias latipes) embryogenesis by ethanol and 5-azacytidine. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 179:174-183. https://doi.org/10.1016/j.cbpc.2015.10.011.

Antibacterial prenylated acylphloroglucinols from Psorothamnus fremontii - (Peer Reviewed Journal)
Yu, Q., Rao, R., Xu, X., Ganji, S., Jacob, M.R., Khan, S.I., Yu, B., Li, X. 2015. Antibacterial prenylated acylphloroglucinols from Psorothamnus fremontii. Organic Letters. 78:2748-2753. https://doi.org/10.1021/acs.jnatprod.5b00721.

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers - (Peer Reviewed Journal)
Avonto, C., Chttiboyina, A.G., Rua, D., Khan, I.A. 2015. A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers. Journal of Toxicology and Applied Pharmacology. 289:177-184.

Constituent composition and biological activity of Nepeta manchuriensis essential oil - (Peer Reviewed Journal)
Gorovoi, P.G., Suleimen, E.M., Dudkin, R.V., Wang, M., Khan, I.A., Ross, S.A. 2015. Constituent composition and biological activity of Nepeta manchuriensis essential oil. Chemistry of Natural Compounds. 51(5):989-990.

Papyracillic acid and its derivatives as biting deterrents against Aedes aegypti(Diptera: Culicidae): structure–activity relationships - (Peer Reviewed Journal)
Cimmino, A., Evidente, M., Masi, M., Ali, A., Tabanca, N., Khan, I.A., Evidente, A. 2015. Papyracillic acid and its derivatives as biting deterrents against Aedes aegypti(Diptera: Culicidae): structure–activity relationships. Medical Chemistry Research. 24:3981-3989.

A New Metabolite with a unique 4-pyranone-ylactam-1,4-thiazine moiety from a Hawaiian-plant associated fungus - (Peer Reviewed Journal)
Li, C., Ding, Y., Yang, B., Miklossy, G., Yin, H., Walker, L.A., Turkson, J., Cao, S. 2015. A New Metabolite with a unique 4-pyranone-ylactam-1,4-thiazine moiety from a Hawaiian-plant associated fungus. Organic Letters. 17(14):3556-9. doi:10.1021/acs.orglett.5b01650.

Polybrominated diphenyl ethers from the marine organisms Lendenfeldia dendyi and Sinularia dura with anti-MRSa activity - (Peer Reviewed Journal)
Radwan, M., Wanas, A.S., Fronczek, F.R., Jacob, M.R., Ross, S.A. 2015. Polybrominated diphenyl ethers from the marine organisms Lendenfeldia dendyi and Sinularia dura with anti-MRSa activity. Medical Chemistry Research. 24:3398-3404.

Bacillusin A, an antibacterial macrodiolide from Bacillus amyloliquefaciens - (Peer Reviewed Journal)
Ravu, R.R., Jacob, M.R., Chen, X., Wang, M., Nasrin, S., Kloepper, J.W., Liles, M.R., Mead, D.A., Khan, I.A., Li, X. 2015. Bacillusin A, an antibacterial macrodiolide from Bacillus amyloliquefaciens. Journal of Natural Products. 78:924-928. https://doi.org/10.1021/np500911k.

Enantioselective pharmacokinetics of primaquine in healthy human volunteers - (Peer Reviewed Journal)
Tekwani, B.L., Avula, B., Sahu, R., Chaurasiya, N.D., Khan, S.I., Jain, S., Fasinu, P.S., Herath, H.B., Stanford, D., Nanayakkara, N.D., Mcchesney, J.D., Yates, T.W., Elsohly, M.A., Khan, I.A., Walker, L.A. 2015. Enantioselective pharmacokinetics of primaquine in healthy human volunteers. Drug Metabolism and Disposition. 43(4):571-7.

High-resolution gas chromatography/mas spectrometry method for characterization and quantitative analysis of ginkgolic acids in ginkgo biloba plants, extracts, and dietary supplements - (Peer Reviewed Journal)
Wang, M., Zhao, J., Avula, B., Wang, Y., Avonto, C., Chittiboyina, A.G., Wylie, P.L., Parcher, J.F., Khan, I.A. 2014. High-resolution gas chromatography/mas spectrometry method for characterization and quantitative analysis of ginkgolic acids in ginkgo biloba plants, extracts, and dietary supplements. Journal of Agricultural and Food Chemistry. 62:12103-12111. https://doi.org/10.1021/jf503980f.

Authentication of true cinnamon (Cinnamon verum) utilising direct analysis in real time (DART)-QWToF-MS - (Peer Reviewed Journal)
Avula, B., Smillie, T.J., Wang, Y., Zweigenbaum, J., Khan, I.A. 2014. Authentication of true cinnamon (Cinnamon verum) utilising direct analysis in real time (DART)-QWToF-MS. Journal of Food Additives & Contaminants. 32:1:1-8. https://doi.org/10.1080/19440049.2014.981763.

Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents - (Peer Reviewed Journal)
Manda, V.K., Dale, O.R., Awortwe, C., Ali, Z., Khan, I.A., Walker, L.A., Khan, S.I. 2014. Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. FRONTIERS IN PHARMACOLOGY. 5(178):1-13. https://doi.org/10.3389/fphar.2014.00178.

Anti-inflammatory activity of constituents isolated from Terminalia chebula ***waiting for publication date - (Peer Reviewed Journal)
Yang, M., Ali, Z., Khan, I.A., Khan, S.I. 2014. Anti-inflammatory activity of constituents isolated from Terminalia chebula. Natural Product Communications. 9(7):965-968.