Research Project: Nutrition and Regenerative Medicine for Preventing Age-Related Neurological Disorders

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Galactic cosmic ray particle exposure does not increase inflammation or oxidative stress in rat microglial cells in vitro - (Peer Reviewed Journal)
Cahoon, D., Fisher, D.R., Rabin, B.M., Lamon-Fava, S., Wu, D., Zheng, T., Shukitt Hale, B. 2024. Galactic cosmic ray particle exposure does not increase inflammation or oxidative stress in rat microglial cells in vitro. International Journal of Molecular Sciences. 25(11):5923. https://doi.org/10.3390/ijms25115923.

Effects of HZE particle exposure location and energy on brain inflammation and oxidative stress in rats - (Peer Reviewed Journal)
Cahoon, D., Rabin, B., Fisher, D.R., Shukitt Hale, B. 2023. Effects of HZE particle exposure location and energy on brain inflammation and oxidative stress in rats. Radiation Research. 200(5):431-443. https://doi.org/10.1667/RADE-22-00041.1.

Extracts from green leafy vegetables and berries, and their major polyphenolics, reduce inflammatory stress signals in HAPI rat microglial cells, in vitro - (Abstract Only)
Fisher, D.R., Marschall, S.N., Zheng, T., Shukitt Hale, B. 2023. Extracts from green leafy vegetables and berries, and their major polyphenolics, reduce inflammatory stress signals in HAPI rat microglial cells, in vitro. [Abstract] Society for Neuroscience Meeting 2023. Program #PSTR203.17.

Perspective: Challenges and Future Directions in Clinical Research with Nuts and Berries - (Other)
Zuelch, M.L., Radtke, M.D., Holt, R.R., Basu, A., Burton-Freeman, B., Ferruzzi, M.G., Li, Z., Shay, N.F., Shukitt Hale, B., Keen, C.L., Steinberg, F.M., Hackman, R.M. 2023. Perspective: Challenges and Future Directions in Clinical Research with Nuts and Berries. Advances in Nutrition. https://doi.org/10.1016/j.advnut.2023.07.010.

A randomised controlled trial to investigate the cognitive, mood and metabolic effects of acute oyster mushroom intervention in older adults (OYSACO) - (Abstract Only)
Cha, S., Bell, L., Shukitt Hale, B., Williams, C. 2023. A randomised controlled trial to investigate the cognitive, mood and metabolic effects of acute oyster mushroom intervention in older adults (OYSACO). [Abstract] 4th International Conference on Food Bioactives and Health. Abstract #FBHC23-0131.

Red raspberry supplemented serum reduces inflammatory stress signals in HAPI rat microglial cells, in vitro - (Abstract Only)
Fisher, D.R., Piccolo, F.X., Xiao, D., Burton-Freeman, B.M., Shukitt Hale, B. 2023. Red raspberry supplemented serum reduces inflammatory stress signals in HAPI rat microglial cells, in vitro. [Abstract]. 7(Suppl 1):101220. https://doi.org/10.1016/j.cdnut.2023.101220.

Low vitamin K intake negatively affects cognition and hippocampal neurogenesis in C57 BL6 mice - (Abstract Only)
Zheng, T., Fu, X., Shen, X., Marschall, S., Smith, D., Tarr, A., Mykyten, K., Biederer, T., Shukitt Hale, B., Booth, S. 2023. Low vitamin K intake negatively affects cognition and hippocampal neurogenesis in C57 BL6 mice. [Abstract]. 7(Suppl 1):101202. https://doi.org/10.1016/j.cdnut.2023.101202.

In Vitro Effects of Myo-Inositol Supplementation on Adult Human Neural Progenitor Cells - (Abstract Only)
Mykyten, K., Fisher, D.R., Biederer, T., Zheng, T. 2023. In Vitro Effects of Myo-Inositol Supplementation on Adult Human Neural Progenitor Cells. [Abstract]. 7(Suppl 1):101233. https://doi.org/10.1016/j.cdnut.2023.101233.

Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles - (Peer Reviewed Journal)
Rabin, B.M., Miller, M.G., Shukitt Hale, B. 2023. Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles. Life Sciences in Space Research. 37:88-96. https://doi.org/10.1016/j.lssr.2023.03.003.

Dietary blueberry before and/or after stressor exposure attenuates neuroinflammation, oxidative stress, and cognitive deficits in rats - (Abstract Only)

Phytochemical combination is more effective than individual components in reducing stress signaling in rat hippocampal neurons and microglia - (Peer Reviewed Journal)
Fisher, D.R., Zheng, T., Bielinski, D.F., Kelly, M.E., Cahoon, D.S., Shukitt Hale, B. 2022. Phytochemical combination is more effective than individual components in reducing stress signaling in rat hippocampal neurons and microglia. International Journal of Molecular Sciences. 23(20):12651. https://doi.org/10.3390/ijms232012651.

Protective effects of a polyphenol-rich blueberry extract on adult human neural progenitor cells - (Peer Reviewed Journal)
Zheng, T., Bielinski, D.F., Fisher, D.R., Zhang, J., Shukitt Hale, B. 2022. Protective effects of a polyphenol-rich blueberry extract on adult human neural progenitor cells. Molecules. 27(19):6152. https://doi.org/10.3390/molecules27196152.

Raspberry phenolics in serum from supplemented adults reduce inflammatory stress signals in HAPI rat microglial cells, in vitro - (Abstract Only)
Fisher, D.R., Piccolo, F.X., Xiao, M., Burton-Freeman, B., Shukitt Hale, B. 2022. Raspberry phenolics in serum from supplemented adults reduce inflammatory stress signals in HAPI rat microglial cells, in vitro [abstract]. Society for Neuroscience Abstracts 2022. Program No. 621.10.

The potential cognitive health impact of berries - (Abstract Only)
Shukitt Hale, B. 2022. The potential cognitive health impact of berries [abstract]. Journal of Natural Health Product Research. 4:18. https://doi.org/10.33211/jnhpr.28.

Low vitamin K intake negatively affects C57BL6 mouse survival and cognition - (Abstract Only)
Zheng, T., Fu, X., Shen, X., Marschall, S., Smith, D., Tarr, A., Biederer, T., Shukitt Hale, B., Booth, S. 2022. Low vitamin K intake negatively affects C57BL6 mouse survival and cognition [abstract]. Current Developments in Nutrition. 6(Suppl 1):816. https://doi.org/10.1093/cdn/nzac064.035.

Long-term supplementation with fruits and vegetables prevents Western-style high-fat diet-induced cognitive impairment in mice - (Abstract Only)
Weimin, G., Shukitt Hale, B., Dayong, W., Li, L., Ortega, E., Meydani, S. 2022. Long-term supplementation with fruits and vegetables prevents Western-style high-fat diet-induced cognitive impairment in mice [abstract]. Current Developments in Nutrition. 6(Suppl 1):790. https://doi.org/10.1093/cdn/nzac064.009.

Dietary blueberry before and/or after exposure to HZE particles attenuates neuroinflammation, oxidative stress, and cognitive deficits in rats - (Abstract Only)
Cahoon, D.S., Fisher, D.R., Zheng, T., Rabin, B.M., Shukitt Hale, B. 2022. Dietary blueberry before and/or after exposure to HZE particles attenuates neuroinflammation, oxidative stress, and cognitive deficits in rats [abstract]. Virtual Online NASA Human Research Program Investigators Workshop. Abstract #1133-000326.

Blueberry treatment administered before and/or after lipopolysaccharide stimulation and oxidative stress in rat microglial cells - (Peer Reviewed Journal)
Cahoon, D.S., Fisher, D.R., Lamon-Fava, S., Wu, D., Zheng, T., Shukitt Hale, B. 2022. Blueberry treatment administered before and/or after lipopolysaccharide stimulation and oxidative stress in rat microglial cells. Nutritional Neuroscience. 26:127-137. https://doi.org/10.1080/1028415X.2021.2020404.

Berry bioactives and cognition - (Book / Chapter)
Bell, L., Shukitt Hale, B., Williams, C.M. 2022. Berry bioactives and cognition. In: Klimis-Zacas, Dorothy and Rodriguez-Mateos, Ana., editors. Berries and Berry Bioactive Compounds in Promoting Health. Cambridge, U.K. Royal Society of Chemistry. p. 185-207.

Blueberry extract attenuates neuroinflammation and oxidative stress when administered before and/or after lipopolysaccharide in rat microglial cells - (Abstract Only)
Cahoon, D., Fisher, D.R., Shukitt Hale, B. 2021. Blueberry extract attenuates neuroinflammation and oxidative stress when administered before and/or after lipopolysaccharide in rat microglial cells. [abstract]. 2021 Society for Neuroscience Annual Meeting. Program #181.07.

Modeling space radiation-induced cognitive dysfunction using targeted and non-targeted effects - (Peer Reviewed Journal)
Shuryak, I., Brenner, D.J., Blattnig, S.R., Shukitt Hale, B., Rabin, B.M. 2021. Modeling space radiation-induced cognitive dysfunction using targeted and non-targeted effects. Scientific Reports. 11:8845. https://doi.org/10.1038/s41598-021-88486-z.

Walnut oil and blueberry treatments have beneficial individual but not synergistic effects on neuroinflammation in vitro - (Abstract Only)
Fisher, D.R., Cahoon, D., Shukitt Hale, B. 2021. Walnut oil and blueberry treatments have beneficial individual but not synergistic effects on neuroinflammation in vitro. Current Developments in Nutrition. 5(Suppl 2):904. https://doi.org/10.1093/cdn/nzab049_017.

Berry phenolics are associated with cognitive enhancement in blueberry- and strawberry-supplemented older adults - (Abstract Only)
Rutledge, G.A., Miller, M.G., Sandhu, A.K., Edirisinghe, I., Burton-Freeman, B., Shukitt Hale, B. 2021. Berry phenolics are associated with cognitive enhancement in blueberry- and strawberry-supplemented older adults. Current Developments in Nutrition. 5(Suppl 2):921. https://doi.org/10.1093/cdn/nzab049_034.

The impact of a walnut-rich breakfast on cognitive performance throughout the day in healthy young adults - (Abstract Only)
Bell, L., Dodd, G.F., Whyte, A.R., Shukitt Hale, B., Williams, C.M. 2021. The impact of a walnut-rich breakfast on cognitive performance throughout the day in healthy young adults. Current Developments in Nutrition. 5(Suppl 2):895. https://doi.org/10.1093/cdn/nzab049_008.

Blueberry treatment administered before and/or after lipopolysaccharide attenuates neuroinflammation and oxidative stress in rat microglial cells - (Abstract Only)
Cahoon, D., Fisher, D.R., Shukitt Hale, B. 2021. Blueberry treatment administered before and/or after lipopolysaccharide attenuates neuroinflammation and oxidative stress in rat microglial cells. Current Developments in Nutrition. 5(Suppl 2):899. https://doi.org/10.1093/cdn/nzab049_012.

Dietary strawberry improves cognition in a randomized, double-blind, placebo-controlled trial using older adults - (Peer Reviewed Journal)
Miller, M.G., Thangthaeng, N., Scott, T.M., Rutledge, G.A., Shukitt Hale, B. 2021. Dietary strawberry improves cognition in a randomized, double-blind, placebo-controlled trial using older adults. British Journal of Nutrition. 126(20):253-263. https://doi.org/10.1017/S0007114521000222.

Effects of preexposure to 4He particles on the alteration of cognitive performance produced by exposure to 56Fe particles in male and female rats - (Abstract Only)
Rabin, B.M., Rottman, V., Shukitt Hale, B. 2021. Effects of preexposure to 4He particles on the alteration of cognitive performance produced by exposure to 56Fe particles in male and female rats. [abstract] NASA Human Research Program IWS 2021 (online), Program #1105-002.

Mechanistically-based model development for space radiation risk assessment: Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects - (Abstract Only)
Brenner, D.J., Shuryak, I., Blattnig, S.R., Shukitt Hale, B., Rabin, B.M. 2021. Mechanistically-based model development for space radiation risk assessment: Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects. [abstract] NASA Human Research Program IWS 2021 (online), Program #1105-002219.

Blueberry phenolics are associated with cognitive enhancement in healthy supplemented older adults - (Peer Reviewed Journal)
Rutledge, G.A., Sandhu, A.K., Miller, M.G., Edirisinghe, I., Burton-Freeman, B.B., Shukitt Hale, B. 2020. Blueberry phenolics are associated with cognitive enhancement in healthy supplemented older adults. Food and Function. 12:107-118. https://doi.org/10.1039/D0FO02125C.

Effects of partial or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats - (Peer Reviewed Journal)
Cahoon, D., Shukitt Hale, B., Bielinski, D.F., Hawkins, E.M., Cacioppo, A.M., Rabin, B.M. 2020. Effects of partial or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats. Life Sciences in Space Research. 27:56-63. https://doi.org/10.1016/j.lssr.2020.07.006.

The Potential Cognitive Health Impact of Strawberries - (Abstract Only)
Shukitt Hale, B. 2020. The Potential Cognitive Health Impact of Strawberries [abstract]. Nutrition Trends Forum 2020 Meeting.

Beneficial effects of blueberry extracts on adult human neural progenitor cells - (Abstract Only)
Bielinski, D.F., Fisher, D.R., Shukitt Hale, B., Zheng, T. 2020. Beneficial effects of blueberry extracts on adult human neural progenitor cells. Current Developments in Nutrition. 4(Suppl_2):1191. https://meeting.nutrition.org.

The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling - (Abstract Only)
Rutledge, G.A., Fisher, D.R., Miller, M.G., Kelly, M.E., Bielinski, D.F., Shukitt Hale, B. 2020. The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling [abstract]. Program book for Translational Research Day, Poster #20, p. 14.

The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro - (Peer Reviewed Journal)
Rutledge, G.A., Fisher, D.R., Miller, M.G., Kelly, M.E., Bielinski, D.F., Shukitt Hale, B. 2019. The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. Food and Function. 10(12):7707-7713. https://doi.org/10.1039/C9FO01913H.

Dietary modulation of the effects of exposure to HZE particles on cognitive performance - (Abstract Only)
Rabin, B.M., Rottman, V., Jiang, V., Hull, M.T., Ingram, I., Shukitt Hale, B. 2020. Dietary modulation of the effects of exposure to HZE particles on cognitive performance [abstract]. 2020 NASA Human Research Program Investigators Workshop, Program #20188.

Factors involved in the beneficial effects of blueberries on cognition - (Abstract Only)
Shukitt Hale, B. 2019. Factors involved in the beneficial effects of blueberries on cognition. 2019 Wild Blueberry Associaton of North America (WBANA) Neuroscience Roundtable.

Factors involved in the beneficial effects of polyphenols on neurochemical and behavioral changes in aging - (Abstract Only)
Shukitt Hale, B., Miller, M.G., Fisher, D.R., Rutledge, G.A., Bielinski, D.F., Scott, T.M. 2019. Factors involved in the beneficial effects of polyphenols on neurochemical and behavioral changes in aging [abstract]. ICoFF2019 program book, Abstract #SY21-4, p. 49.