Research Project: Biobased Pesticide Discovery and Product Optimization and Enhancement from Medicinal and Aromatic Crops

Location: Natural Products Utilization Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Chemical mimicry in the corpse flower: Floral odor and phytochemical profiles of Amorphophallus titanum (Becc.) Becc. - (Peer Reviewed Journal)
Raman, V., Wang, M., Avula, B., Khan, I. 2024. Floral scent analysis and phytochemical profiling of titan arum (Amorphophallus titanum) by headspace-solid phase microextraction gas chromatography/liquid chromatography coupled with quadrupole-time of flight mass spectromet. Biochemical Systematics and Ecology. 118:1-12. https://doi.org/10.1016/j.bse.2024.104.

Insecticidal and repellent activity of Piper crassinervium essential oil and its pure compounds against imported fire ants (Hymenoptera: Formicidae). - (Peer Reviewed Journal)
Shah, F., Wang, M., Zhao, J., Lee, J., Farago, P., Manfron, J., Khan, I.A., Ali, A. 2024. Insecticidal and repellent activity of Piper crassinervium essential oil and its pure compounds against imported fire ants (Hymenoptera: Formicidae).. Molecules. 29:1-12. https://doi.org/10.3390/molecules29225430.

Bioactive Secondary Metabolites from Curvularia spp.: Natural Alternatives for Pest Management in Agriculture - (Peer Reviewed Journal)

Characterization of the Phytotoxic Potential of Seven Copaifera spp. Essential Oils: Analyzing Active Compounds through Gas Chromatography–Mass Spectrometry Molecular Networking - (Peer Reviewed Journal)
Ribeiro, V.P., Bajsa Hirschel, J.N., Bastos, J., Reichley, A.C., Duke, S.O., Meepagala, K.M. 2024. Characterization of the Phytotoxic Potential of Seven Copaifera spp. Essential Oils: Analyzing Active Compounds through Gas Chromatography–Mass Spectrometry Molecular Networking. Journal of Agricultural and Food Chemistry. 72:18528-18536. https://doi.org/10.1021/acs.jafc.4c04586.

Juniperus sabina L. essential oils and podophyllotoxin seasonal and interpopulation dynamics - (Peer Reviewed Journal)
Zheljazkov, V., Semerdjieva, I., De Martino, L., Cantrell, C.L., Astatkie, T., Francolino, R., Martino, M., Radoukova, T., De Feo, V., Maneva, V., Atanasova, D., Caputo, L., Alzahrani, A., Borisova, D. 2024. Juniperus sabina L. essential oils and podophyllotoxin seasonal and interpopulation dynamics. Industrial Crops and Products. 219:1-19. https://doi.org/10.1016/j.indcrop.2024.119128.

Bioprospecting and Repurposing of Leaf Biomass to Support Sustainable Biopharmacy: Evaluation of Seasonal Chemical Variations and Biological Activities of Six Eucalyptus Essential Oils - (Peer Reviewed Journal)
Migacz IP, Wang M., Faoro JAM, dos Santos E, Formagio ASN, Kassuya CAL, Rheman JU, Perera W, Gonçalves VC. Chaves DSA, Raman V, Farago PV, Khan IK, Manfron J. Bioprospecting and repurposing of leaf biomass to support sustainable biopharmacy: Evaluation of seasonal chemical variations and biological activities of six eucalyptus essential oils. Int J Environ Res 18, 74, 2024. https://doi.org/10.1007/s41742-024-00628-z (407785)

Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing - (Peer Reviewed Journal)
Tamang, P., Upadhaya, A., Paudel, P., Meepagala, K.M., Cantrell, C.L. 2024. Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing. Microorganisms. 12:1-17. https://doi.org/10.3390/microorganisms12030548.

Rapid preparation and proton NMR fingerprinting of polysaccharides from Radix Astragali - (Peer Reviewed Journal)
Cao, L., Zhao, J., Wang, M., Khan, I. A., & Li, X.-C. (2024). Rapid preparation and proton NMR fingerprinting of polysaccharides from Radix Astragali. Carbohydrate Research, 536, 109053. doi:10.1016/j.carres.2024.109053

Novel pyrazole acyl(thio)urea derivatives containing a biphenyl scaffold as potential succinate dehydrogenase inhibitors: Design, synthesis, fungicidal activity and SAR - (Peer Reviewed Journal)
Sun, N., Min, L., Sun, Z., Zhai, Z., Bajsa Hirschel, J.N., Wei, Z., Hua, X., Cantrell, C.L., Xu, H., Duke, S.O., Liu, X. 2024. Novel pyrazole acyl(thio)urea derivatives containing a biphenyl scaffold as potential succinate dehydrogenase inhibitors: Design, synthesis, fungicidal activity and SAR. Journal of Agricultural and Food Chemistry. 72:2512-2525. https://doi.org/10.1021/acs.jafc.3c07735.

Comprehensive quality assessment of peppermint oils and commercial products: An integrated approach involving conventional and chiral GC/MS coupled with chemometrics - (Peer Reviewed Journal)
Wang, M., Lee, J., Zhao, J., Lee, J., Chatterjee, S., Chittiboyina, A.G., Ali, Z., Khan, I.A. 2023. Comprehensive quality assessment of peppermint oils and commercial products: An integrated approach involving conventional and chiral GC/MS coupled with chemometrics. Journal of Chromatography B. 1232:123953. https://doi.org/10.1016/j.jchromb.2023.123953.

Antifungal and Phytotoxic activities of isolated compounds from Helietta parvifolia stems - (Peer Reviewed Journal)
Ribeiro, V., Bajsa Hirschel, J.N., Tamang, P., Meepagala, K.M., Duke, S. 2023. Antifungal and phytotoxic activities of isolated compounds from Helietta parvifolia stems. Molecules. 28(23):7930. https://doi.org/10.3390/molecules28237930.

Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties - (Peer Reviewed Journal)
Adams, S.J., Lee, J., Avula, B., Katragunta, K., Wang, M., Parveen, I., Techen, N., Chittiboyina, A., Khab, I. 2023. Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties. South African Journal of Botany. 164:77-90. https://doi.org/10.1016/j.sajb.2023.11.038.

Chemical profile, antioxidant and antimicrobial activity of Pinus heldreichii Christ. distributed in Bulgaria - (Peer Reviewed Journal)
Semerdjieva, I., Cantrell, C.L., Zheljazkov, V.D., Radoukova, T., Koleva-Valkova, L.H., Astatkie, T., Kacaniova, M., Borisova, D. 2023. Chemical profile, antioxidant and antimicrobial activity of Pinus heldreichii Christ. distributed in Bulgaria. Heliyon. 10:1-15. https://doi.org/10.1016/j.heliyon.2023.e22967.

Bioactive metabolites produced by fungi present in Antarctic, Arctic and alpine ecosystems - (Book / Chapter)
Gonçalves, V.N., Carvalho, C.R., Martins, L.M., Barreto, D.L., Queiroz, S.C., Tamang, P., Bajsa Hirschel, J.N., Cantrell, C.L., Duke, S.O., Rosa, L.H. 2024. Bioactive metabolites produced by fungi present in Antarctic, Arctic and alpine ecosystems. In: Abdel-Azeem, A.M., Yadav, A.N., Yadav, N., Sharma, M., editors. Bioactive Metabolites from Fungi in Pharmaceutical Research and Development: Prospects & Avenues. p. 537-563. https://doi.org/10.1007/978-981-99-5696-8_17.

Discovery of highly efficient novel antifungal leads targeting succinate dehydrogenase: pyrazole-4-carboxamide derivatives with an N-phenyl substituted amide fragment - (Peer Reviewed Journal)
Sun, X., Yu, C., Li-Jing, M., Cantrell, C.L., Hua, X., Sun, N., Liu, X. 2023. Discovery of highly efficient novel antifungal leads targeting succinate dehydrogenase: pyrazole-4-carboxamide derivatives with an N-phenyl substituted amide fragment. Journal of Agricultural and Food Chemistry. 71:19312-19323. https://doi.org/10.1021/acs.jafc.3c04842.

The Cardiorenal Effects of Piper amalago Are Mediated by the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway and the Voltage-Dependent Potassium Channels Ethnopharmacological investigation of Piper amalago L - (Peer Reviewed Journal)
Monteiro, L.M., Klider, L.M., Marques, A.A., Farago, P.V., Emiliano, J., Souza, R.I., Dos Santos, A.C., Dos Santos, V.L., Wang, M., Cassemiro, N.S., Silva, D.B., Khan, I.A., Gasparotto,Jr, A., Manfron, J. 2023. The Cardiorenal Effects of Piper amalago Are Mediated by the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway and the Voltage-Dependent Potassium Channels Ethnopharmacological investigation of Piper amalago L. Pharmaceuticals. 16:1-24. https://doi.org/10.3390/ph16111630.

Capsiate-rich fraction of Capsicum annuum induces muscular glucose uptake, ameliorates rosiglitazone-induced adipogenesis, and exhibits activation of NRs regulating multiple signaling pathways - (Peer Reviewed Journal)
Chae, H., Cantrell, C.L., Khan, I.A., Jarret, R.L., Khan, S.I. 2023. Capsiate-rich fraction of Capsicum annuum induces muscular glucose uptake, ameliorates rosiglitazone-induced adipogenesis, and exhibits activation of NRs regulating multiple signaling pathways. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.3c06148?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as.

Synthesis, herbicidal activity and in silico analysis of novel pyrido[2,3-d]pyrimidine compounds - (Peer Reviewed Journal)
Liang, W., Wang, Q., Min, L., Han, L., Cantrell, C.L., Bajsa Hirschel, J.N., Duke, S.0., Ye, P., Liu, X. 2023. Synthesis, herbicidal activity and in silico analysis of novel pyrido[2,3-d]pyrimidine compounds. Molecules. https://doi.org/10.3390/molecules28217363.

Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China - (Peer Reviewed Journal)
Tan, L., He, Y., Li, S., Deng, J., Avula, B., Zhang, J., Nirmal, P.D., Solis-Sainz, J., Wang, M. 2023. Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China. Journal of Food Composition and Analysis. https://doi.org/10.1016/j.jfca.2023.105798.

Validation of a Toll-like receptor (TLR)2/TLR1 activation assay for biological standardization of Arthrospira/Limnospira immune-enhancing potency - (Peer Reviewed Journal)
Haron, M.H., Zhang, J., Chittiboyina, A.G., Khan, I.A., Pugh, N.D. 2023. Validation of a Toll-like receptor (TLR)2/TLR1 activation assay for biological standardization of Arthrospira/Limnospira immune-enhancing potency. Journal of Dietary Supplements. https://doi.org/10.1080/19390211.2023.2263566.

Synthesis, Herbicidal Activity, and Structure-Activity Relationships of O-Alkyl Analogues of Khellin and Visnagin - (Peer Reviewed Journal)
Cantrell, C.L., Travaini, M., Bajsa Hirschel, J.N., Svendsen, L.D., Reichley, A.C., Sosa, G.M., Kim, S., Tamang, P., Meepagala, K.M., Duke, S.O. 2023. Synthesis, Herbicidal Activity, and Structure-Activity Relationships of O-Alkyl Analogues of Khellin and Visnagin. Journal of Agriculture and Food Chemistry. 71:14593-14603. https://doi.org/10.1021/acs.jafc.3c03254.

Chemical profile and cytotoxic activity of essential oils from six species of Baccharis subgenus Coridifoliae (Asteraceae) - (Peer Reviewed Journal)
De Almeida, V.P., Tolouei, S.E., Minteguiaga, M., Heiden, G., Khan, S.I., Wang, M., Dellacasa, E., Raman, V., Farago, P.V., Khan, I.A., Junior, A.G., Manfron, J. 2023. Chemical profile and cytotoxic activity of essential oils from six species of Baccharis subgenus Coridifoliae (Asteraceae). Chemistry and Biodiversity. 20:1-13. https://doi.org/10.1002/cbdv.202300862.

Physiological and Biochemical Responses of Turmeric (Curcuma longa L.) Under Drought Stress - (Peer Reviewed Journal)
Bharadwaj, B., Sanathanam, S., Pham, T., Cantrell, C.L., Wang, M., Mentreddy, S., Basu, C. 2024. Physiological and Biochemical Responses of Turmeric (Curcuma longa L.) Under Drought Stress. Journal of Medicinally Active Plants. 13:40-55. https://doi.org/10.7275/jmap.2315.

Influence of genetics on the secondary metabolism of fungi - (Book / Chapter)
Costa Barreto, D., De Carvalho, C.R., De Almeida Alves, T., Zani, C., Cantrell, C.L., Duke, S.O., Rosa, L. 2023. Influence of genetics on the secondary metabolism of fungi. Natural Secondary Metabolites – from Nature, Through Science, to Industry. https://doi.org/10.1007/978-3-031-18587-8_22.

Isolation of two plasticizers, bis(2-ethylhexyl) terephthalate and bis(2-ethylhexyl) phthalate, from Capparis spinosa L. leaves - (Peer Reviewed Journal)
Kdimy, A., Kim, S., Ali, Z., Khan, M.H., Tripathi, S.K., Hajjaji, S.E., Le, H.V. 2023. Isolation of two plasticizers, bis(2-ethylhexyl) terephthalate and bis(2-ethylhexyl) phthalate, from Capparis spinosa L. leaves. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202300903.

Defining the toxicological profile of 4-hydroxyphenylpyruvate dioxygenase-directed herbicides to Aedes aegypti and Amblyomma americanum - (Peer Reviewed Journal)
Mccomic, S.E., Duke, S.O., Burgess Iv, E.R., Swale, D.R. 2023. Defining the toxicological profile of 4-hydroxyphenylpyruvate dioxygenase-directed herbicides to Aedes aegypti and Amblyomma americanum. Pesticide Biochemistry and Physiology. https://doi.org/10.1016/j.pestbp.2023.105532.

6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites - (Peer Reviewed Journal)
Avula, B., Bae, J., Ahn, J., Wang, Y., Wang, M., Kwon, Y., Chittiboyina, A.G., Khan, I.A. 2023. 6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241411487.

Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF - (Peer Reviewed Journal)
Wang, M., Zhao, J., Avula, B., Lee, J., Upton, R., Khan, I. 2023. Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2023.115570.

Cannabinoid receptor type II ligands from sandalwood oil and synthetic alpha-santalol derivatives - (Peer Reviewed Journal)
Paudel, P., Pandey, P., Paris, J.J., Ashpole, N.M., Mahdi, F., Tian, J., Lee, J., Wang, M., Xu, M., Chittiboyina, A.G., Khan, I.A., Ross, S.A., Li, X. 2023. Cannabinoid receptor type II ligands from sandalwood oil and synthetic alpha-santalol derivatives. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.3c00282.

Determining the optimum mixture of three essential oils for potato sprout suppression at room temperature storage - (Peer Reviewed Journal)
Thoma, J., Cantrell, C.L., Tamang, P., Zheljazkov, V.D. 2023. Determining the optimum mixture of three essential oils for potato sprout suppression at room temperature storage. Frontiers in Plant Science. https://doi.org/10.3389/fpls.2023.1199117.

Why are there no widely successful microbial bioherbicides for weed management in crops? - (Peer Reviewed Journal)
Duke, S.O. 2023. Why are there no widely successful microbial bioherbicides for weed management in crops?. Pest Management Science. 80:56-94. https://doi.org/10.1002/ps.7595.

Metabolomic evaluation of soil Streptomyces sp. for the discovery of novel biopesticidal constituents - (Abstract Only)
Kim, S., Estep Iii, A.S., Tamang, P., Cantrell, C.L. 2023. Metabolomic evaluation of soil Streptomyces sp. for the discovery of novel biopesticidal constituents. Meeting Abstract. National Meeting of the American Chemical Society, Denver, CO.

Lack of significant effects of glyphosate on glyphosate-resistant maize in different field locations - (Peer Reviewed Journal)
Simionato Bidóa, V., Dos Santos Neto, J.C., De Goes Maciel, C.D., Tropaldi, L., Carbonari, C.A., Duke, S.O., De Carvalho, L.B. 2023. Lack of significant effects of glyphosate on glyphosate-resistant maize in different field locations. Agronomy. 13(10. Article 13041071. https://doi.org/10.3390/agronomy13041071.

Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS - (Peer Reviewed Journal)
Lee, J., Wang, M., Zhao, J., Ali, Z., Hawwal, M., Khan, I. 2023. Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS. Plants. https://doi.org/10.3390/plants12081619.

Applicability of LC-QToF and microscopic tools in combating 2 the sophisticated, economically motivated adulteration of 3 poppy seeds - (Peer Reviewed Journal)
Avula, B.; Katragunta, K.; Adams, S.J.; Wang, Y.-H.; Chittiboyina, A.G.; Khan, I.A. Applicability of LC-QToF and Microscopical Tools in Combating the Sophisticated, Economically Motivated Adulteration of Poppy Seeds. Foods 2023, 12, 1510. https://doi.org/10.3390/foods12071510

Antifungal activity of Poncirus trifoliata roots against Colletotrichum species - (Peer Reviewed Journal)
Meepagala, K.M., Tamang, P. 2023. Antifungal activity of Poncirus trifoliata roots against Colletotrichum species. Agricultural Sciences. https://doi.org/10.4236/as.2023.143022.

Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control - (Monograph)
Wang, M. 2023. Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control. American Herbal Pharmacopoeia and Therapeutic Compendium. 1.

Utilization of phylogenetic information to aid in the discovery of novel bioactive constituents from soil Streptomyces sp - (Abstract Only)
Kim, S., Tamang, P., Estep Iii, A.S., Cantrell, C.L. 2023. Utilization of phylogenetic information to aid in the discovery of novel bioactive constituents from soil Streptomyces sp. Meeting Abstract. International Conference on the Science of Botanicals, Oxford, MS.

Alleviation of cocaine withdrawal and pertinent interactions between salvinorin-based antagonists and kappa opioid receptor - (Peer Reviewed Journal)
Akins, N.S., Mohammed, S.F., Pandey, P., Kim, S., Mahdi, F., Khan, M.H., Moss, E., Worth, C.J., Keanne, M.M., Chittiboyina, A.G., Doerksen, R.J., Paris, J.J., Le, H.V. 2023. Alleviation of cocaine withdrawal and pertinent interactions between salvinorin-based antagonists and kappa opioid receptor. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.2c00806.

Fungal biosurfactants: applications in agriculture, medicine, industry and in environmental bioremediation processes - (Book / Chapter)
Drumond De Souza, L.M., Costa Barreto, D.L., Da Costa Coelho, L., Amancio Teixeira, E.A., Nicolau Goncalves, V., Muzetti Ribeiro, J.P., Gontijo Rabelo, N., De Oliveira Alves, S.E., Da Silva, L.M., Cantrell, C.L., Duke, S.O., Henrique Rosa, L. 2023. Fungal biosurfactants: applications in agriculture, medicine, industry and in environmental bioremediation processes. In: Marcelino, P.R.F., Da Silva, S.S., Lopez, A.O., editors. Biosurfactants and Sustainability: From Biorefineries Production to Versatile Applications. Hoboken, NJ:John Wiley & Sons Ltd. p 243-254.

Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-gamma-methyleneglutamic acid amides for cancer - (Peer Reviewed Journal)
Khan, M.H., Mahdi, F., Penformis, P., Akins, N.S., Hossain, M., Kim, S., Sulochana, S.P., Adam, A.T., Tran, T.D., Tan, C., Claudio, P., Paris, J.J., Hoang, L.V. 2022. Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-gamma-methyleneglutamic acid amides for cancer. Bioorganic and Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2022.117137.

Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis - (Peer Reviewed Journal)
Matundura, J.O., Midiwo, J.O., Yenesew, A., Omosa, L., Kumarihamy, M., Zhao, J., Wang, M., Tripathi, S., Khan, S., Masila, V.M., Nchiozem-Ngnitedem, V., Muhammad, I. 2022. Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis. Natural Product Research. https://doi.org/10.1080/14786419.2022.2158463.

Effects of essential oil fumigation on potato sprouting at room-temperature storage - (Peer Reviewed Journal)
Thoma, J., Cantrell, C.L., Zheljazkov, V.D. 2022. Effects of essential oil fumigation on potato sprouting at room-temperature storage. Plants. https://doi.org/10.3390/plants11223109.

Evaluation of essential oils as sprout suppressants for potato (Solanum tuberosum) at room temperature storage - (Peer Reviewed Journal)
Thoma, J., Cantrell, C.L., Zheljazkov, V.D. 2022. Evaluation of essential oils as sprout suppressants for potato (Solanum tuberosum) at room temperature storage. Plants. https://doi.org/10.3390/plants11223055.

Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction to evaluate the in vitro metabolism of ß-Caryophyllene - (Peer Reviewed Journal)
Lee, J., Wang, M., Mondal, G., Khan, I.A., Yates, C.R. 2022. Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction to evaluate the in vitro metabolism of ß-Caryophyllene. Molecules. https://doi.org/10.3390/molecules27217441.

Melissa officinalis L. as a sprout suppressor in Solanum tuberosum L. and an alternative to synthetic pesticides - (Peer Reviewed Journal)
Zheljazkov, V.D., Micalizzi, G., Yilma, S., Cantrell, C.L., Reichley, A.C., Mondello, L., Semerdjieva, I., Radoukova, T. 2022. Melissa officinalis L. as a sprout suppressor in Solanum tuberosum L. and an alternative to synthetic pesticides. Journal of Agriculture and Food Chemistry. https://doi.org/10.1021/acs.jafc.2c05942.

Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways - (Peer Reviewed Journal)
Kumarihamy, M., Tripathi, S., Balachandran, P., Avula, B., Zhao, J., Wang, M., Bennett, M., Carr, M.A., Micheal, L., Ocean, W.I., Marquart, M.E., Nanayakkara, D., Muhammad, I. 2022. Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways. Molecules. https://doi.org/10.3390/molecules27196604.

Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoro-methylpyrazoyl moiety - (Peer Reviewed Journal)
Shi, H., Zhai, Z., Min, L., Han, L., Sun, N., Cantrell, C.L., Bajsa Hirschel, J.N., Duke, S.O., Liu, X. 2022. Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoro-methylpyrazoyl moiety. Research on Chemical Intermediates. https://doi.org/10.1007/s11164-022-04839-x.

Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials - (Peer Reviewed Journal)
Cao, L., Wang, M., Zhao, J., Peng, L., Cheng, J., Qiu, S., Khan, I., Li, X. 2022. Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials. Medicinal Plant Biology. https://doi.org/10.48130/MPB-2022-0004.

Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues - (Peer Reviewed Journal)
Min, L., Shen, Z., Bajsa Hirschel, J.N., Cantrell, C.L., Han, L., Hua, X., Liu, X., Duke, S.O. 2022. Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues. Pesticide Biochemistry and Physiology. https://doi.org/10.1016/j.pestbp.2022.105228.

Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira - (Peer Reviewed Journal)
Huh, J., Zhang, J., Hauerová, R., Lee, J., Haider, S., Wang, M., Hauer, T., Khan, I., Chittiboyina, A., Pugh, N. 2022. Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira. Scientific Reports. https://doi.org/10.1038/s41598-022-19590-x.

Phytochemical investigation of Egyptian Spinach leaves, a potential source for antileukemic metabolites: in vitro and in silico study - (Peer Reviewed Journal)
Abdelgawad, S.M., Hetta, M.H., Ibrahim, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian Spinach leaves, a potential source for antileukemic metabolites: in vitro and in silico study. Revista Brasileira de Farmacognosia. https://doi.org/10.1007/s43450-022-00307-0.

Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations - (Peer Reviewed Journal)
Zhao, J., Wang, M., Sabastian, J.A., Lee, J., Chittiboyina, A.G., Avula, B., Ali, Z., Li, J., Wu, C., Khan, I. 2022. Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2022.115012.

Essential oil composition of Pinus heldreichii Christ., P. peuce Griseb., and P. mugo Turra as a function of hydrodistillation time and evaluation of its antimicrobial activity - (Peer Reviewed Journal)
Semerdjieva, I.B., Radoukova, T., Cantrell, C.L., Astatkie, T., Kacanlova, M., Borisova, D., Zheljazkov, V.D. 2022. Essential oil composition of Pinus heldreichii Christ., P. peuce Griseb., and P. mugo Turra as a function of hydrodistillation time and evaluation of its antimicrobial activity. Industrial Crops and Products. 187(Part B). Article 115484. https://doi.org/10.1016/j.indcrop.2022.115484.

Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics - (Peer Reviewed Journal)
Lee, J., Wang, M., Jianping, Z., Avula, B., Chittiboyinaa, A.G., Khan, I.A. 2022. Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics. Foods. https://doi.org/10.3390/foods11142132.

Phytochemical investigation of Egyptian riverhemp: a potential source of antileukemic metabolites - (Peer Reviewed Journal)
Abdelgawad, S.M., Hett, M.H., Ibrahima, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian riverhemp: a potential source of antileukemic metabolites. Journal of Natural Medicine. https://doi.org/10.1155/2022/8766625.

Evaluation of the phytotoxic and antifungal activity of C17-sesquiterpenoids as potential biopesticides - (Peer Reviewed Journal)
Cárdenas, D.M., Bajsa Hirschel, J.N., Cantrell, C.L., Rial, C., Varela, R.M., Molinillo, J.G., Macías, F.A. 2022. Evaluation of the phytotoxic and antifungal activity of C17-sesquiterpenoids as potential biopesticides. Pest Management Science. https://doi.org/10.1002/ps.7042.

Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig - (Peer Reviewed Journal)
Avula, B., Bae, J., Chittiboyina, A.G., Wang, Y., Wang, M., Zhao, J., Zulfiqar, A., Li, J., Wu, C., Khan, I.A. 2022. Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig. Journal of Agricultural and Food Chemistry. https://doi.org/10.1016/j.jfca.2022.104679.

Streptomyces distallicus, a potential microbial biolarvicide - (Abstract Only)
Kim, S., Cantrell, C.L., Ali, A., Avula, B., Chen, J., Schrader, K., Suikinai Nobre, S. 2022. Streptomyces distallicus, a potential microbial biolarvicide. American Chemical Society Abstracts. 1 p.

Phytochemical variability of essential oils of two Balkan endemic species Satureja pilosa Velen. and S. kitaibelii Wierzb. ex Heuff. (Lamiaceae) - (Peer Reviewed Journal)
Zheljazkov, V.D., Semerdjieva, I.B., Cantrell, C.L., Astatkie, T., Acimovic, M. 2022. Phytochemical variability of essential oils of two Balkan endemic species Satureja pilosa Velen. and S. kitaibelii Wierzb. ex Heuff. (Lamiaceae). Molecules. https://doi.org/10.3390/molecules27103153.

Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species) - (Peer Reviewed Journal)
Wang, M., Cantrell, C.L., Matthews, S.T., Paudel, P., Lee, J., Mentreddy, S.R. 2022. Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acsfoodscitech.2c00100?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as.

Essential oil content, composition, and bioactivity of sagebrush species in the Bighorn Mountains - (Peer Reviewed Journal)
Zheljazkov, V.D., Cantrell, C.L., Jeliazkova, E.L., Astatkie, T., Schlegel, V. 2022. Sagebrush species of the U.S. Bighorn Mountains: essential oil content, composition, and bioactivity. Plants. https://doi.org/10.3390/plants11091228.

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3+2]-cycloaddition of nitrile oxides and 1,3-diketones, ß-ketoesters, or ß-ketoamides: Base-mediated and keto-enol-controlled mechanism. - (Peer Reviewed Journal)
Hossain, M., Khan, M.H., Kim, S., Le, H.V. 2022. Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3+2]-cycloaddition of nitrile oxides and 1,3-diketones, ß-ketoesters, or ß-ketoamides: Base-mediated and keto-enol-controlled mechanism.. Beilstein Journal of Organic Chemistry. https://doi.org/10.3762/bjoc.18.47.

A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata - (Peer Reviewed Journal)
Kamau, R.W., Midiwo, J.O., Mgani, Q.A., Masila, V.M., Kumarihamy, M., Wang, M., Zhao, J., Muhamma, I. 2022. A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata. Natural Product Research. https://doi.org/10.1080/14786419.2022.2062349.

Novel dioxolane ring compounds for the management of phytopathogen diseases as ergosterol biosynthesis inhibitors: synthesis, biological activities and molecular docking - (Peer Reviewed Journal)
Min, L., Wang, H., Bajsa Hirschel, J.N., Yu, C., Wang, B., Yao, M., Han, L., Cantrell, C.L., Duke, S.O., Sun, N., Liu, X. 2022. Novel dioxolane ring compounds for the management of phytopathogen diseases as ergosterol biosynthesis inhibitors: synthesis, biological activities and molecular docking. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.2c00541.

Bulk process for enrichment of capsinoids from capsicum fruit - (Peer Reviewed Journal)
Cantrell, C.L., Jarret, R.L. 2022. Bulk process for enrichment of capsinoids from capsicum fruit. Processes. 10(2):305. https://doi.org/10.3390/pr10020305.

6,5-fused ring, C2-salvinorin ester, dual kappa and mu opioid receptor agonists as analgesics devoid of anxiogenic effects. - (Peer Reviewed Journal)
Akins, N.S., Mishra, N., Harris, H.M., Dudhipala, N., Kim, S., Keasling, A.W., Zjawiony, J.K., Ashpole, N.M., Le, H.V. 2022. 6,5-fused ring, C2-salvinorin ester, dual kappa and mu opioid receptor agonists as analgesics devoid of anxiogenic effects.. ChemMedChem. https://doi.org/10.1002/cmdc.202100684.

Phytochemical investigation and reproductive capacity of the Bulgarian endemic plant species Marrubium friwaldskyanum Boiss. (Lamiaceae) - (Peer Reviewed Journal)
Zheljazkov, V.D., Semerdjieva, I.B., Stevens, J.F., Wu, W., Cantrell, C.L., Yankova-Tsvetkova, E., Koleva-Valkova, L.H., Stoyanova, A., Astatkie, T. 2021. Phytochemical investigation and reproductive capacity of the Bulgarian endemic plant species Marrubium friwaldskyanum Boiss. (Lamiaceae). Journal of Agricultural and Food Chemistry. https://doi.org/10.3390/plants11010114.

Comparative analysis of five salvia species using LC-DAD-QToF - (Peer Reviewed Journal)
Avula, B., Bae, J., Chittiboyinaa, A.A., Wang, Y., Wang, M., Srivedavyasasri, R., Ali, Z., Li, J., Wu, C., Khan, I.A. 2021. Comparative analysis of five salvia species using LC-DAD-QToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114520.

Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots - (Peer Reviewed Journal)
Maciel, G., Aparecida Lopes, A., Cantrell, C.L., De Castro Franca, S., Waleria Bertoni, B., Verginia Lourenco, M. 2021. Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots. Plant Cell Tissue and Organ Culture. https://doi.org/10.1007/s11240-021-02201-4.

Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods - (Peer Reviewed Journal)
Avonto, C., Chittiboyina, A.G., Khan, S.I., Dale, O.R., Parcher, J.F., Wang, M., Khan, I.A. 2020. Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods. Toxicology In Vitro. 70. Article e105053. https://doi.org/10.1016/j.tiv.2020.105053.

NMR technique and methodology in botanical health product analysis and quality control - (Peer Reviewed Journal)
Zhao, J., Wang, M., Saroja, S.G., Khan, I.A. 2021. NMR technique and methodology in botanical health product analysis and quality control. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114376.

Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies - (Peer Reviewed Journal)
Shankara, V., Wang, M., Ajjarapua, S., Kolimi, P., Avula, B., Murthy, R., Khan, I., Naraisimha, M. 2021. Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpha.2021.08.004.

Discovery 5a-pregnan-2ß,3a-diol-20-one as a neuroHIV protective agent - (Abstract Only)

Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair - (Peer Reviewed Journal)
Huijuan, Q., Lin, K., Li, X., Ou, H., Tan, Y., Wang, M., Wei, N. 2021. Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202100214.

Synthesis and antifungal activity evaluation of phloeodictine analogues - (Peer Reviewed Journal)
Ravu, R., Jacob, M.R., Khan, S.I., Wang, M., Cao, L., Agarwal, A.K., Clark, A.M., Li, X. 2021. Synthesis and antifungal activity evaluation of phloeodictine analogues. Journal of Natural Products. 84,2129-2137. https://doi.org/10.1021/acs.jnatprod.1c00116.

Characterization of the allelopathic potential of sugarcane leaves and roots - (Peer Reviewed Journal)
Hijano, N., Nepomuceno, M.P., Cantrell, C.L., Duke, S.O., Alves, P.L. 2021. Characterization of the allelopathic potential of sugarcane leaves and roots. Journal of Agricultural Chemistry and Environment. https://doi.org/10.4236/jacen.2021.103016.

(E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil - (Peer Reviewed Journal)
Hawwal, M.F., Ali, Z., Wang, M., Zhao, J., Lee, J., Fantoukh, O.I., Khan, I.A. 2021. (E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil. Molecules. 2021, 26, 4456. https://doi.org/10.3390/molecules26154456.

Microbial transformation of some simple isoquinoline and benzyl isoquinoline alkaloids and molecular docking studies of the metabolites - (Peer Reviewed Journal)
El-Aasr, M., Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., Ross, S.A., Khan, S.I. 2021. Microbial transformation of some simple isoquinoline and benzyl isoquinoline alkaloids and molecular docking studies of the metabolites. Phytochemistry. https://doi.org/10.1016/j.phytochem.2021.112828.

Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry - (Peer Reviewed Journal)
Avula, B., Bae, J., Wang, Y., Wang, M., Ali, Z., Khan, I.A. 2021. Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry. Nature Product Communications. https://doi.org/10.1093/jaoacint/qsab075.

A novel approach for lavender essential oil authentication and quality assessment - (Peer Reviewed Journal)
Wang, M., Zhao, J., Ali, Z., Avonto, C., Khan, I. 2021. A novel approach for lavender essential oil authentication and quality assessment. Journal of Pharmaceutical and Biomedical Analysis. 199. Article e114050. https://doi.org/10.1016/j.jpba.2021.114050.

Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC - (Peer Reviewed Journal)
Avula, B., Bae, J., Zhao, J., Wang, Y., Wang, M., Zhang, Z., Ali, Z., Khan, I. 2021. Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114036.

In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity - (Peer Reviewed Journal)
Abdelmalek, E.M., Zulfiqar, F., Albadry, M.A., Khan, S.I., Meepagala, K.M., Ramadan, M.A., Darwish, F.M., Assaf, M.H., Ross, S.A. 2021. In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity. Phytochemistry. 185. https://doi.org/10.1016/j.phytochem.2021.112745.

Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia - (Peer Reviewed Journal)
Balachandran, P., Ibrahim, M.A., Zhang, J., Wang, M., Pasco, D.S., Muhammad, I. 2021. Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia. Molecules. 26/735. https://doi.org/10.3390/molecules26030735.

Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm - (Peer Reviewed Journal)
Muhammad, I., Jacob, M.R., Ibrahim, M.A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Sutton, M., Rahman, M., Zhao, J. 2020. Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm. Molecules. 25/6000. https://doi.org/10.3390/molecules25246000.

Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl - (Peer Reviewed Journal)
Shaukat, U., Ahemad, S., Wang, M., Khan, S.I., Ali, Z., Muhammad I, T.I., Abdallah, H.H., Khan, I.A., Saleem, M., Mahomoodally, M.F. 2021. Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl. South African Journal of Botany. 138:148-155. https://doi.org/10.1016/j.sajb.2020.12.010.

Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz - (Peer Reviewed Journal)
Zhai, C., Zhao, J., Chittiboyina, A.G., Meng, Y., Wang, M., Khan, S.I., Khan, I.A. 2020. Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz. Molecules. https://doi.org/10.3390/molecules25245904.

Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a - (Peer Reviewed Journal)
Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., El-Aasr, M., Ross, S.A. 2020. Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a. Phytochemistry. https://doi.org/10.1016/j.phytochem.2020.112598.

Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine - (Peer Reviewed Journal)
Wei, N., Wang, M., Adams, S.J., Yu, P., Avula, B., Wang, Y., Pan, K., Wang, Y., Khan, I.A. 2020. Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis. 194. Article e113801. https://doi.org/10.1016/j.jpba.2020.113801.

Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows - (Peer Reviewed Journal)
Stefenoni, H., Räisänen, S., Cueva Welchez, S., Wasson, D., Lage, C., Melgar, A., Fetter, M., Smith, P., Hennessy, M., Vecchiarelli, B., Bender, J., Pitta, D., Cantrell, C.L., Yarish, C., Hristov, A. 2021. Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows. Journal of Dairy Science. 104:4157-4173. https://doi.org/10.3168/jds.2020-19686.

Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae) - (Peer Reviewed Journal)
Perera, W.H., Meepagala, K.M., Duke, S.O. 2020. Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae). Biochemical Systematics and Ecology. 93,104176. https://doi.org/10.1016/j.bse.2020.104176.

Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils - (Peer Reviewed Journal)
De Oliveira, T.L., Fontana, P.D., Bavia, L., Cruz, L., Crisma, A.R., Sassaki, G.L., Menezes, L.R., Wang, M., Beltrame, F., Messias-Reason, I.J. 2020. Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils. Journal of Ethnopharmacology. 265/113348. https://doi.org/10.1016/j.jep.2020.113348.