Research Project: Improving Dairy Cow Feed Efficiency and Environmental Sustainability Using Genomics and Novel Technologies to Identify Physiological Contributions and Adaptations

Location: Animal Genomics and Improvement Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Transcriptomic data reveals MYC as an upstream regulator in laying hen follicular recruitment - (Peer Reviewed Journal)
Kramer, A.E., Ellwood, K., Guarina, N., Li, C., Dutta, A. 2024. Transcriptomic data reveals MYC as an upstream regulator in laying hen follicular recruitment. Poultry Science. https://doi.org/10.1016/j.psj.2024.104547.

Integrative analysis of whole genome bisulfite and transcriptome sequencing reveals the effect of sodium butyrate on DNA methylation in the differentiation of bovine skeletal muscle satellite cells - (Peer Reviewed Journal)
Wang, X., Zhou, X., Li, C., Qu, C., Shi, Y., Li, C., Kang, X. 2024. Integrative analysis of whole genome bisulfite and transcriptome sequencing reveals the effect of sodium butyrate on DNA methylation in the differentiation of bovine skeletal muscle satellite cells. Genomics. 116(6):110959. https://doi.org/10.1016/j.ygeno.2024.110959.

Effects of rumen metabolite butyric acid on bovine skeletal muscle satellite cells proliferation, apoptosis, and transcriptional states during myogenic differentiation - (Peer Reviewed Journal)
Wang, X., Ding, Y., Li, C., Ma, Q., Shi, Y., Liu, G., Li, C., Kang, X. 2024. Effects of rumen metabolite butyric acid on bovine skeletal muscle satellite cells proliferation, apoptosis, and transcriptional states during myogenic differentiation. Domestic Animal Endocrinology. https://doi.org/10.1016/j.domaniend.2024.106892.

Transcriptomic profiling of gastrointestinal tracts in dairy cattle during lactation reveals molecular adaptations for milk synthesis - (Peer Reviewed Journal)
Gao, Y., Liu, G., Ma, L., Fang, L., Li, C., Baldwin, R.L. 2024. Transcriptomic profiling of gastrointestinal tracts in dairy cattle during lactation reveals molecular adaptations for milk synthesis. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2024.06.020.

Assessing different cross-validation schemes for predicting novel traits using sensor data: an application to dry matter intake and residual feed intake using milk spectral data - (Peer Reviewed Journal)
Adkinson, A.Y., Abouhawwash, M., Parker Gaddis, K.L., Burchard, J., Penagaricano, F., White, H.M., Weigel, K.A., Baldwin, R.L., Santos, J.E., Vandehaar, M.J., Koltes, J.E., Tempelman, R.J. 2024. Assessing different cross-validation schemes for predicting novel traits using sensor data: an application to dry matter intake and residual feed intake using milk spectral data. Journal of Dairy Science. https://doi.org/10.3168/jds.2024-24701.

Genetic characterization of daily feeding pattern in lactating Holstein cows and its association with feed efficiency - (Peer Reviewed Journal)

Genetic characterization of daily feeding pattern in lactating Holstein cows and its association with feed efficiency - (Abstract Only)
Cavani, L., Parker Gaddis, K.L., Baldwin, R.L., Santos, J.E., Koltes, J.E., Tempelman, R.J., Vandehaar, M.J., White, H.M., Penagaricano, F., Weigel, K. 2024. Genetic characterization of daily feeding pattern in lactating Holstein cows and its association with feed efficiency [abstract]. Journal of Dairy Science. 107(Suppl. 1):39(abstr. 1192).

Impact of heat stress on dry matter intake in mid-lactation Holstein cows - (Abstract Only)
Nascimento, B.M., Cavani, L., Parker Gaddis, K.L., Baldwin, R.L., Santos, J.E., Koltes, J.E., Tempelman, R.J., Vandehaar, M.J., White, H.M., Penagaricano, F., Weigel, K. 2024. Impact of heat stress on dry matter intake in mid-lactation Holstein cows [abstract]. Journal of Dairy Science. 107(Suppl. 1):17-18(abstr. 1139).

Deriving novel traits based on data from sensors and other technologies - (Abstract Only)
Koltes, J.E., James, L., Mayes, M., Cooper, C., Parker-Gaddis, K.L., Van Raden, P.M., Baldwin, R.L., Santos, J.E., Tempelman, R.J., White, H.M., Penagaricano, F., Weigel, K., Vandehaar, M.J. 2024. Deriving novel traits based on data from sensors and other technologies [abstract]. Journal of Dairy Science. 107(Suppl. 1):39(abstr. 1191).

Consistency of dry matter intake in Holstein cows: heritability estimates and associations with feed efficiency - (Peer Reviewed Journal)
Cavani, L., Parker Gaddis, K.L., Baldwin, R.L., Santos, J.E., Koltes, J.E., Tempelman, R.J., Vandehaar, M.J., White, H.M., Penagaricano, F., Weigel, K.A. 2024. Consistency of dry matter intake in Holstein cows: Heritability estimates and associations with feed efficiency. Journal of Dairy Science. 107(2):1054–1067. https://doi.org/10.3168/jds.2023-23774.

Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway - (Peer Reviewed Journal)
Ding, Y., Wang, P., Zhang, Y., Yang, C., Zhou, X., Wang, X., Li, C., Su, Z., Ming, W., Zeng, L., Shi, Y., Li, C., Kang, X. 2023. Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway. International Journal of Molecular Sciences. 24:13474. https://doi.org/10.3390/ijms241713474.

Estimation of genetic parameters for feed efficiency traits using random regression models in dairy cattle - (Peer Reviewed Journal)
Houlahan, K., Schenkel, F., Miglior, F., Jamrozik, J., Lassen, J., Gonzalez-Recio, O., Charfeddine, N., Segelke, D., Butty, A., Stratz, P., Vanderhaar, M., Weigel, K., White, H., Koltes, J., Santos, J., Baldwin, R.L., Baes, C. 2024. Estimation of genetic parameters for feed efficiency traits using random regression models in dairy cattle. Journal of Dairy Science. 107(3):1523–1534. https://doi.org/10.3168/jds.2022-23124.

The Resilient Dairy Genome Project - A general overview of methods and objectives related to feed efficiency and methane emissions - (Peer Reviewed Journal)
Van Staaveren, N., De Oliveira, H.R., Houlahan, K., Chud, T.C., Oliveira, Jr, G.A., Hailemariam, D., Kistemaker, G., Miglior, F., Plastow, G., Schenkel, F.S., Cerri, R., Sirard, M., Stothard, P., Pryce, J., Butty, A., Stratz, P., Abdalla, E.A., Segelke, D., Stamer, E., Thaller, G., Lassen, J., Manzanilla-Pech, C., Stephansen, R.B., Charfeddine, N., Garcia-Rodriguez, A., Gonzalez-Recio, O., Lopez-Paredes, J., Baldwin, R.L., Burchard, J., Parker Gaddis, K.L., Koltes, J.E., Penagaricano, F., Santos, J.E., Tempelman, R.J., Vandehaar, M.J., Weigel, K.A., White, H.M., Baes, C. 2024. The Resilient Dairy Genome Project - A general overview of methods and objectives related to feed efficiency and methane emissions . Journal of Dairy Science. 107(3):1510–1522. https://doi.org/10.3168/jds.2022-22951.

Genome-wide acetylation modification of H3K27ac in bovine rumen cell following butyrate exposure - (Peer Reviewed Journal)
Kang, X., Li, C., Liu, S., Baldwin, R.L., Liu, G., Li, C.-J. 2023. Genome-wide acetylation modification of H3K27ac in bovine rumen cell following butyrate exposure. Biomolecules. 13(7):1137. https://doi.org/10.3390/biom13071137.

Consistency of daily dry matter intake as an indicator of resilience: heritability estimates and associations with feed efficiency in Holstein cows - (Abstract Only)
Cavani, L., Parker Gaddis, K., Baldwin, R.L., Santos, J., Koltes, J., Tempelman, R., Vandehaar, M., White, H., Penagaricano, F., Weigel, K. 2023. Consistency of daily dry matter intake as an indicator of resilience: Heritability estimates and associations with feed efficiency in Holstein cows [abstract]. Journal of Dairy Science. 106(Suppl. 1):121(abstr. 2514).

Pedigree and genomic adjustments for single-step genomic BLUP applied to residual feed intake - (Abstract Only)
Legarra, A., Vandehaar, M., Tempelman, R., Koltes, J., White, H., Weigel, K., Baldwin, R.L., Van Raden, P.M., Penagaricano, F., Santos, J., Parker Gaddis, K. 2023. Pedigree and genomic adjustments for single-step genomic BLUP applied to residual feed intake [abstract]. Journal of Dairy Science. 106(Suppl. 1):189(abstr. 2714).

Predicting dry matter intake in Canadian Holstein dairy cattle using milk mid-infrared reflectance spectroscopy and other commonly available predictors via artificial neural networks - (Peer Reviewed Journal)
Shadpour, S., Chud, T.C., Hailemariam, D., De Oliveira, H.R., Plastow, G., Stothard, P., Lassen, J., Baldwin, R.L., Miglior, F., Baes, C.F., Tulpan, D., Schenkel, F.S. 2022. Predicting dry matter intake in Canadian Holstein dairy cattle using milk mid-infrared reflectance spectroscopy and other commonly available predictors via artificial neural networks. Journal of Dairy Science. 105(10):8257–8271. https://doi.org/10.3168/jds.2021-21297.