Research Project: Nutrient Metabolism and Musculoskeletal Health in Older Adults

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Optimization of vitamin D status in global populations - (Review Article)
Harvey, N.C., Ward, K.A., Agnusdei, D., Binkley, N., Biver, E., Campusano, C., Cavalier, E., Clark, P., Diaz-Curiel, M., El-Hajj Fuleihan, G., Khashayer, P., Lane, N.E., Messina, O.D., Mithal, A., Rizzoli, R., Sempos, C., Dawson-Hughes, B. 2024. Optimization of vitamin D status in global populations. Osteoporosis International. https://doi.org/10.1007/s00198-024-07127-z.

Association between visual acuity and prospective fall risk in generally healthy and active older adults: the 3-year DO-HEALTH study - (Peer Reviewed Journal)
Wieczorek, M., Isler, M., Landau, K., Becker, M.D., Dawson-Hughes, B., Kressig, R.W., Vellas, B., Orav, E.J., Rizzoli, R., Kanis, J.A., Armbrecht, G., da Silva, J.A., Egli, A., Freystatter, G., Bischoff-Ferrari, H. 2024. Association between visual acuity and prospective fall risk in generally healthy and active older adults: the 3-year DO-HEALTH study. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. https://doi.org/10.1016/j.jamda.2024.03.005.

Effects of vitamin D3, omega-3s and a simple strength training exercise program on bone health: the Do-Health randomized controlled trial - (Peer Reviewed Journal)
Kistler-Fischbacher, M., Armbrecht, G., Gangler, S., Theiler, R., Rizzoli, R., Dawson-Hughes, B., Kanis, J.A., Hofbauer, L.C., Schimmer, R.C., Vellas, B., Da Silva, J.A., Orav, J.E., Kressig, R.W., Egli, A., Lang, W., Wanner, G.A., Bischoff-Ferrari, H. 2024. Effects of vitamin D3, omega-3s and a simple strength training exercise program on bone health: the Do-Health randomized controlled trial. Journal of Bone and Mineral Research. https://doi.org/10.1093/jbmr/zjae054.

Effects of testosterone and vitamin D on fall risk in pre-frail hypogonadal men: a factorial design RCT - (Peer Reviewed Journal)
Bischoff-Ferrari, H.A., Kisttler-Fischbacher, M., Gaengler, S., Munzer, T., Dawson-Hughes, B., Lang, W., Theiler, R., Egli, A., Orav, J.E., Freystetter, G. 2024. Effects of testosterone and vitamin D on fall risk in pre-frail hypogonadal men: a factorial design RCT. Journal of Nutrition Health and Aging. https://doi.org/10.1016/j.jnha.2024.100217.

Matrix Gla protein and the long-term incidence and progression of coronary artery and aortic calcification in the Multi-Ethnic Study of Atherosclerosis - (Peer Reviewed Journal)
Berlot, A.A., Fu, X., Shea, K., Tracy, R., Budoff, M., Kim, R.S., Naveed, M., Booth, S.L., Kizer, J.R., Bortnick, A.E. 2024. Matrix Gla protein and the long-term incidence and progression of coronary artery and aortic calcification in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. https://doi.org/10.1016/j.atherosclerosis.2024.117505.

Promoting healthy aging through nutrition: a research centers collaborative network workshop report - (Review Article)
Shea, K., Strath, L., Kim, M., Doan, L., Booth, S.L., Brinkley, T., Kritchevsky, S. 2024. Promoting healthy aging through nutrition: a research centers collaborative network workshop report. Advances in Nutrition. https://doi.org/10.1016/j.advnut.2024.100199.

Effect of a GH secretagogue, anamorelin, on serum irisin and inflammation levels in osteosarcopenic adults - (Peer Reviewed Journal)
Dawson-Hughes, B., Konieczynski, E.M., Reitshamer, E., Ceglia, L. 2024. Effect of a GH secretagogue, anamorelin, on serum irisin and inflammation levels in osteosarcopenic adults. Journal of the Endocrine Society. https://doi.org/10.1210/jendso/bvae028.

Mitochondria-targeted catalase does not suppress development of cellular senescence during aging - (Peer Reviewed Journal)
Mogck, B., Jezak, S., Wiley, C. 2024. Mitochondria-targeted catalase does not suppress development of cellular senescence during aging. Biomedicines. https://doi.org/10.3390/biomedicines12020414.

A meta-analysis of previous falls and subsequent fracture risk in cohort studies - (Peer Reviewed Journal)
Vanderput, L., Johansson, H., McCloskey, E.V., Liu, E., Schini, M., Akesson, K.E., Anderson, F.A., Azagra, R., Bager, C.L., Beaudart, C., Bischoff-Ferrara, H., Biver, E., Bruyere, O., Cauley, J.A., Center, J.R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C.J., Cummings, S., da Silva, J.A., Dawson-Hughes, B., Diez-Perez, A., Dufour, A.B., Eisman, J.A., Elders, P., Ferrari, S., Fujita, Y., Fujiwara, S., Gluer, C.C., Goldshtein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R.J., Huisman, M., Iki, M., Shalom, S.I., Jones, G., Karlsson, M., Khosla, S., Kiel, D., Koh, W., Koromani, F., Kotowicz, M., Kroger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., Mcguigan, F.E., Mellstrom, D., Merlijn, T., Nguyen, T.V., Nordstrom, A., Nordstrom, P., O'Neill, T.W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E.S., Pasco, J., Rivadeneira, F., Schott, A., Shiroma, E.J., Siggeirsdottir, K., Simonsick, E.M., Sornay-Rendu, E., Sund, R., Swart, K.M., Szulc, P., Tamaki, J., Torgerson, D., van Schoor, N.C., van Staa, T.P., Vila, J., Wareham, N.J., Wright, N.C., Yoshimura, N., Zillikens, M.C., Zwart, M., Harvey, N.C., Lorentzon, M., Leslie, W.D., Kanis, J.A. 2024. A meta-analysis of previous falls and subsequent fracture risk in cohort studies. Osteoporosis International. https://doi.org/10.1007/s00198-023-07012-1.

Dietary intakes of community-dwelling adults in the United States across older adulthood: NHANES 2015-March 2020 - (Peer Reviewed Journal)
Shea, K., Barger, K., Rogers, G., Talegawkar, S., Eicher-Miller, H., Booth, S.L. 2024. Dietary intakes of community-dwelling adults in the United States across older adulthood: NHANES 2015-March 2020. Journal of Nutrition. https://doi.org/10.1016/j.tjnut.2023.12.014.

Effect of anamorelin, a ghrelin receptor agonist, on muscle and bone in adults with osteosarcopenia - (Peer Reviewed Journal)
Dawson-Hughes, B., Barger, K., Reitshamer, E., Fielding, R.A., Evans, W., Ceglia, L. 2023. Effect of anamorelin, a ghrelin receptor agonist, on muscle and bone in adults with osteosarcopenia. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgad702.

Senescent cells at the crossroads of aging, disease, and tissue homeostasis - (Review Article)
Kuehnemann, C., Wiley, C. 2023. Senescent cells at the crossroads of aging, disease, and tissue homeostasis. Aging Cell. https://doi.org/10.1111/acel.13988.

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX - (Peer Reviewed Journal)
Kanis, J.A., Johansson, H., McKloskey, E.V., Liu, E., Akesson, K., Anderson, F.A., Axagra, R., Bager, C.L., Beaudart, C., Bischoff-Ferrari, H.A., Biver, E., Bruyere, O., Cauley, J.A., Center, J.R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C.J., Cummings, S.R., da Silva, J.A., Dawson-Hughes, B., Diez-Perez, A., Dufour, A.B., Eisman, J.A., Elders, P.J., Ferrari, S.J., Fujita, Y., Fujiwara, S., Gluer, C.C., Goldshtein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R.J., Huisman, M., Iki, M., Ish-Shalom, S., Joens, G., Karlsson, M.K., Khosla, S., Kiel, D., Koh, W.P., Koromani, F., Kotowicz, M.A., Kroger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., Mellstrom, D., Merlijn, T., Nordstrom, A., Nordstrom, P., O'Neill, T.W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E.S., Pasco, J., Rivadeneira, F., Schott, A., Shiroma, E.J., Siggeirsdottir, K., Simonsick, E., Sornay-Rendu, E., Sund, R., Swart, K., Szulc, P., Tamaki, J., Torgerson, D.J., Van Schoor, N.M., Van Staa, T.P., Vila, J., Wareham, N.J., Wright, N.C., Yoshimura, N., Zillikens, M.C., Zwart, M., Vandenput, L., Harvey, N.C., Lorentzon, M., Leslie, W.D. 2023. Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX. Osteoporosis International. https://doi.org/10.1007/s00198-023-06870-z.

Estimation of absolute and relative body fat content using non-invasive surrogates: Can DXA be bypassed? - (Peer Reviewed Journal)
Greenblatt, D.J., Bruno, C.D., Harmatz, J.S., Dawson-Hughes, B., Zhang, Q., Li, C., Chow, C.R. 2023. Estimation of absolute and relative body fat content using non-invasive surrogates: Can DXA be bypassed?. Journal of Clinical Pharmacology. https://doi.org/10.1002/jcph.2306.

Effect of vitamin D on regression to normal glucose regulation and individual glycemic measures: A secondary analysis among participants adherent to the trial protocol in the randomized clinical trial vitamin D and type 2 ... - (Peer Reviewed Journal)
Hsia, D.S., Nelson, J., Vickery, E.M., Rasouli, N., Leblanc, E.S., Kim, S., Brodsky, I., Pratley, R., Dawson-Hughes, B., Pittas, A.G. 2023. Effect of vitamin D on regression to normal glucose regulation and individual glycemic measures: A secondary analysis among participants adherent to the trial protocol in the randomized clinical trial vitamin D and type 2 diabetes (D2d) study. Diabetes Research and Clinical Practice. https://doi.org/10.1016/j.diabres.2023.110792.

Effect of vitamin D supplementation on glycemia: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study - (Peer Reviewed Journal)
Hsia, D.S., Nelson, J., Vickery, E.M., Rasouli, N., LeBlanc, E.S., Kim, S., Brodsky, I., Pratley, R., Dawson-Hughes, B., Pittas, A.G. 2023. Effect of vitamin D supplementation on glycemia: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study. Diabetes Research and Clinical Practice. https://doi.org/10.1016/j.diabres.2023.110792.

Lack of consensus between measurements of plasma phylloquinone by enzyme-linked immunoassays and a well-validated high performance liquid chromatographic method - (Peer Reviewed Journal)
Ruditser, R., Fu, X., Booth, S.L., Liu, M., Shen, X., Shea, K. 2023. Lack of consensus between measurements of plasma phylloquinone by enzyme-linked immunoassays and a well-validated high performance liquid chromatographic method. Current Developments in Nutrition. https://doi.org/10.1016/j.cdnut.2023.101959.

The human milk component myo-inositol promotes neuronal connectivity - (Peer Reviewed Journal)
Paquette, A., Carbone, B.E., Vogel, S., Israel, E., Maria, S.D., Labhart, B., Morrow, A.L., Phillips, S.C., Kuang, C., Hondmann, D., Pandey, N., Biederer, T. 2023. The human milk component myo-inositol promotes neuronal connectivity. Proceedings of the National Academy of Sciences (PNAS). https://doi.org/10.1073/pnas.2221413120.

Intake of dark green vegetables may benefit specific cognitive domains in US men and women aged 60 years or older - (Peer Reviewed Journal)
Bigman, G., Shea, K., Rusu, M., Ryan, A.S. 2023. Intake of dark green vegetables may benefit specific cognitive domains in US men and women aged 60 years or older. Journal of Nutrition Health and Aging. https://doi.org/10.3233/NHA-220193.

Measuring health-related quality of life in sarcopenia: summary of the SarQoL psychometric properties - (Review Article)
Beaudart, C., Reginster, J., Smith, J., Bautmans, I., Bauer, J., Burlet, N., Cesare, M., Cherubini, A., Cooper, C., Cruz-Jentoft, A.J., Dawson-Hughes, B., Fielding, R.A., Harvey, N.C., Landi, F., Laslop, A., Maggi, S., Montero-Errasquin, B., Prieto Yerro, M., Rolland, Y., Rizzzoli, R., Visser, M. 2023. Measuring health-related quality of life in sarcopenia: summary of the SarQoL psychometric properties. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-023-02438-3.

Association between a calcium to magnesium ratio and osteoporosis among Puerto Rican older adults - (Peer Reviewed Journal)
Fouhy, L.E., Mangano, K.M., Zhang, X., Dawson-Hughes, B., Tucker, K.L., Noel, S.E. 2023. Association between a calcium to magnesium ratio and osteoporosis among Puerto Rican older adults. Journal of Bone and Mineral Research. https://doi.org/10.1016/j.tjnut.2023.05.009.

Effect of intra-trial mean 25(OH)D level on diabetes risk, by race and weight: an ancillary analysis in the D2d study - (Peer Reviewed Journal)
Chatterjee, R., Davenport, C.A., Vickery, E.M., Johnson, K.C., Kashyap, S.R., Leblanc, E.S., Nelson, J., Dagogo-Jack, S., Pittas, A.G., Dawson-Hughes, B. 2023. Effect of intra-trial mean 25(OH)D level on diabetes risk, by race and weight: an ancillary analysis in the D2d study. The American Journal of Clinical Nutrition. https://doi.org/10.1016/j.ajcnut.2023.03.021.

An exploratory case-control study on associations of bacterially derived vitamin K forms with the intestinal microbiome and obesity-related osteoarthritis - (Peer Reviewed Journal)
Liu, M., Matuszek, G.H., Azacarate-Peril, A., Loeser, R., Shea, K. 2023. An exploratory case-control study on associations of bacterially derived vitamin K forms with the intestinal microbiome and obesity-related osteoarthritis. Current Developments in Nutrition. https://doi.org/10.1016/j.cdnut.2023.100049.

Cholesterol drives inflammatory senescence - (Review Article)
Kuehnemann, C., Wiley, C. 2023. Cholesterol drives inflammatory senescence. Nature Metabolism. https://doi.org/10.1038/s42255-023-00758-2.

Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes - (Peer Reviewed Journal)
Ceglia, L., Pittas, A.G., Dawson-Hughes, B. 2023. Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-022-02338-y.

Vitamin D and risk for type 2 diabetes in people with prediabetes: a systematic review and meta-analysis of individual participant data from 3 randomized clinical trials - (Peer Reviewed Journal)
Pittas, A.G., Kawahara, T., Jorde, R., Dawson-Hughes, B., Vickery, E.M., Angellotti, E., Nelson, J., Trikalinos, T.A., Balk, E.M. 2023. Vitamin D and risk for type 2 diabetes in people with prediabetes: a systematic review and meta-analysis of individual participant data from 3 randomized clinical trials. Annals of Internal Medicine. https://doi.org/10.7326/M22-3018.

Vitamin K - (Book / Chapter)

Prevalence of sarcopenia among generally healthy community-dwelling adults in a large multinational European population: Baseline data of the DO-HEALTH trial - (Peer Reviewed Journal)
Stuck, A.K., Tsai, L., Freystatter, G., Vellas, B., Kanis, J.A., Rizzoli, R., Kressig, R., Armbrecht, G., da Silva, J.A., Dawson-Hughes, B., Egli, A.A., Bischoff-Ferrari, H.A. 2023. Prevalence of sarcopenia among generally healthy community-dwelling adults in a large multinational European population: Baseline data of the DO-HEALTH trial. Journal of Nutrition Health and Aging. https://doi.org/10.1007/s12603-023-1888-y.

Association between multimorbidity and rate of falls: a 3-year 5-country prospective study in generally healthy and active community-dwelling adults aged 70+ - (Peer Reviewed Journal)
Huberty, S., Freystatter, G., Wieczorek, M., Dawson-Hughes, B., Kanis, J.A., Rizzoli, R., Kressig, R., Vellas, B., Da Silva, J., Armbrecht, G., Theiler, R., Egli, A.L., Orav, E., Bischoff-Ferrari, H.A. 2023. Association between multimorbidity and rate of falls: a 3-year 5-country prospective study in generally healthy and active community-dwelling adults aged 70+. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. https://doi.org/10.1016/j.jamda.2022.12.011.

Cellular senescence, a novel area of investigation for metastatic diseases - (Review Article)
Faggioli, F., Velarde, M., Wiley, C. 2022. Cellular senescence, a novel area of investigation for metastatic diseases. Preprints. https://doi.org/10.20944/preprints202211.0564.v1.

Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal - (Peer Reviewed Journal)
Kuehnemann, C., Hughes, J.B., Desprez, P., Melov, S., Wiley, C., Campisi, J. 2022. Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal. Aging Cell. https://doi.org/10.1111/acel.13750.

Association of Vitamin K status with arterial calcification and stiffness in chronic kidney disease: The chronic renal insufficiency cohort - (Peer Reviewed Journal)
Shea, K., Wang, J., Barger, K., Weiner, D.E., Townsend, R., Feldman, H.I., Rosas, S., Chen, J., He, J., Flack, J., Jaar, B., Kansal, M., Booth, S.L. 2022. Association of Vitamin K status with arterial calcification and stiffness in chronic kidney disease: The chronic renal insufficiency cohort. Current Developments in Nutrition. https://doi.org/10.1016/j.cdnut.2022.100008.

Effect of vitamin D3 vs. calcifediol on VDR concentration and fiber size in skeletal muscle - (Peer Reviewed Journal)
Ceglia, L., Rivas, D.A., Schloegl, M., Fielding, G.B., Egli, A.L., Bischoff-Ferrari, H.A., Dawson-Hughes, B. 2022. Effect of vitamin D3 vs. calcifediol on VDR concentration and fiber size in skeletal muscle. Journal of Bone and Mineral Metabolism. https://doi.org/10.1007/s00774-022-01374-y.

The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis - (Review Article)
Kanis, J.A., McCloskey, E.V., Harvey, N.C., Cooper, C., Rizzoli, R., Dawson-Hughes, B., Maggi, S., Reginster, J. 2022. The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis. Osteoporosis International. https://doi.org/10.1007/s00198-022-06567-9.

Dietary intake of flavonols associated with global cognitive decline and multiple cognitive abilities - (Peer Reviewed Journal)
Holland, T.M., Agarwal, P., Wang, Y., Dhana, K., Leurgans, S.E., Shea, K., Booth, S.L., Rajan, K.B., Schneider, J.A., Barnes, L.L. 2023. Dietary intake of flavonols associated with global cognitive decline and multiple cognitive abilities. Neurology. https://doi.org/10.1212/WNL.0000000000201541.

Vitamin D in the older population: A consensus statement - (Review Article)
Giustina, A., Bouillon, R., Dawson-Hughes, B., Ebeling, P.R., Lazaretti-Castro, M., Lips, P., Marcocci, C., Bilezikian, J.P. 2022. Vitamin D in the older population: A consensus statement. Endocrine. https://doi.org/10.1007/s12020-022-03208-3.

Brain vitamin D forms, cognitive decline and neuropathology in community-dwelling older adults - (Peer Reviewed Journal)
Shea, K., Barger, K., Dawson-Hughes, B., Leurgans, S.E., Fu, X., James, B.D., Holland, T.M., Agarwal, P., Wang, J., Matuszek, G.H., Heger, N., Schneider, J.A., Booth, S.L. 2022. Brain vitamin D forms, cognitive decline and neuropathology in community-dwelling older adults. Alzheimer's & Dementia. https://doi.org/10.1002/alz.12836.

Effects of vitamin D with calcium and associations of mean 25-hydroxyvitamin D levels with 3-year change in muscle performance in healthy older adults in the Boston STOP IT trial - (Peer Reviewed Journal)
Dawson-Hughes, B., Wang, J., Barger, K., Ceglia, L. 2022. Effects of vitamin D with calcium and associations of mean 25-hydroxyvitamin D levels with 3-year change in muscle performance in healthy older adults in the Boston STOP IT trial. Calcified Tissues International. https://doi.org/10.1007/s00223-022-01024-5.

Nutritional aspects of healthy aging - (Review Article)
Panda, A., Booth, S.L. 2022. Nutritional aspects of healthy aging. Medical Clinics of North America. 106(5): 853-864. https://doi.org/10.1016/j.mcna.2022.04.008.

Intervention thresholds and diagnostic thresholds in the management of osteoporosis - (Other)
Kanis, J.A., Mccloskey, E.V., Harvey, N.C., Cooper, C., Rizzoli, R., Dawson-Hughes, B., Maggi, S., Reginster, J. 2022. Intervention thresholds and diagnostic thresholds in the management of osteoporosis. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-022-02216-7.

Adult vitamin D deficiency: fracture & fall prevention - (Book / Chapter)
Dawson-Hughes, B., Bischoff-Ferrari, H.A. 2023. Adult vitamin D deficiency: fracture & fall prevention. In: Feldman and Pike's Vitamin D. 5th edition. Elsevier. https://doi.org/10.1016/B978-0-323-91338-6.00021-5.

Vitamin K status and cognitive function in adults with chronic kidney disease: The Chronic Renal Insufficiency Cohort - (Peer Reviewed Journal)
Shea, K., Wang, J., Barger, K., Weiner, D.R., Booth, S.L., Seliger, S., Anderson, A.H., Deo, R., Feldman, H.I., Go, A., He, J., Ricardo, A.C., Tamura, M.K. 2022. Vitamin K status and cognitive function in adults with chronic kidney disease: The Chronic Renal Insufficiency Cohort. Current Developments in Nutrition. https://doi.org/10.1093/cdn/nzac111.

Extracellular nicotinamide phosphoribosyltransferase is a component of the senescence-associated secretory phenotype - (Peer Reviewed Journal)
Kuehnemann, C., Hu, K., Butera, K., Patel, S.K., Bons, J., Schilling, B., Aguayo-Mazzucato, C., Wiley, C. 2022. Extracellular nicotinamide phosphoribosyltransferase is a component of the senescence-associated secretory phenotype. Frontiers in Endocrinology. 13:Article 935106. https://doi.org/10.3389/fendo.2022.935106.

A randomized study on the effect of dried fruit on acid-base balance, diet quality, and markers of musculoskeletal health in community dwelling adults - (Peer Reviewed Journal)
Ceglia, L., Shea, K., Rasmussen, H., Gilhooly, C., Dawson-Hughes, B. 2022. A randomized study on the effect of dried fruit on acid-base balance, diet quality, and markers of musculoskeletal health in community dwelling adults. Journal of the American Nutrition Association. https://doi.org/10.1080/27697061.2022.2082599.

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan - (Peer Reviewed Journal)
Vandenput, L., Johansson, H., McCloskey, E.V., Liu, E., Akesson, K.E., Anderson, F.A., Azagra, R., Bager, C.L., Beaudart, C., Bischoff-Ferrari, H.A., Biver, E., Bruyere, O., Cauley, J.A., Center, J.R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C.J., Cummings, S.R., Da Silva, J., Dawson-Hughes, B., Diez-Perez, A., Dufour, A.B., Eisman, J.A., Elders, P.J., Ferrari, S., Fujita, Y., Fujiwara, S., Gluer, C.C., Goldstein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R.J., Huisman, M., Iki, M., Ish-Shalom, S., Jones, G., Karlsson, M.K., Khosla, S., Kiel, D.P., Koh, W.P., Koromani, F., Kotowicz, M.A., Kroger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., Mellstrom, D., Merlijn, T., Nordstrom, A., Nordstrom, P., O'Neill, T.W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E.S., Pasco, J.A., Rivadeneira, F., Schei, B., Schott, A.M., Shiroma, E.J., Siggeirsdottir, K., Simonsick, E.M., Sornay-Rendu, E., Sund, R., Swart, K.M., Szulc, P., Tamaki, J., Torgenson, D.J., Van Schoor, N.M., Van Staa, T.P., Vila, J., Wareham, N.J., Wright, N.C., Yoshimura, N., Zillikens, M.C., Zwart, M., Harvey, N.C., Lorentzon, M., Leslie, W.D., Kanis, J.A. 2022. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan. Osteoporosis International. 33:3103-2136. https://doi.org/10.1007/s00198-022-06435-6.

Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (The iPACK-HD Study): A randomized, placebo-controlled multi-centre, pilot trial - (Peer Reviewed Journal)
Holden, R.M., Booth, S.L., Zimmerman, D., Moist, L., Norman, P., Day, A.G., Menard, A., Fu, X., Shea, K., Babiolakis, C.S., Nolan, R., Turner, M.E., Ward, E., Kaufmann, M., Adams, M.A., Heyland, D.K. 2022. Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (The iPACK-HD Study): A randomized, placebo-controlled multi-centre, pilot trial. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfac191.

Leveraging observational cohorts to study diet and nutrition in older adults: Opportunities and obstacles - (Review Article)
Shea, K., Ardisson Korat, A., Jacques, P., Sebastiani, P., Cohen, R., Lavertu, A., Booth, S.L. 2022. Leveraging observational cohorts to study diet and nutrition in older adults: Opportunities and obstacles. Advances in Nutrition. https://doi.org/10.1093/advances/nmac031.

Combined vitamin D, omega-3 fatty acids, and a simple home exercise program may reduce cancer risk among active adults aged 70 and older: a randomized clinical trial - (Peer Reviewed Journal)
Bischoff-Ferrari, H.A., Willett, W.C., Manson, J.E., Dawson-Hughes, B., Manz, M.G., Theiler, R., Brandle, K., Vellas, B., Rizzoli, R., Kressig, R.W., Staehelin, H.B., Da Silva, J.A., Ambrecht, G., Egli, A., Kanis, J., Orav, E.J., Gangler, S. 2022. Combined vitamin D, omega-3 fatty acids, and a simple home exercise program may reduce cancer risk among active adults aged 70 and older: a randomized clinical trial. British Medical Journal. 3:852643. https://doi.org/10.3389/fragi.2022.852643.

Feeding practice and delivery mode are determinants of vitamin K in the infant gut: An exploratory analysis - (Peer Reviewed Journal)
Ellis, J.L., Wang, M., Fu, X., Fields, C.J., Donovan, S.M., Booth, S.L. 2022. Feeding practice and delivery mode are determinants of vitamin K in the infant gut: An exploratory analysis. Current Developments in Nutrition. 6(3):nzac019. https://doi.org/10.1093/cdn/nzac019.

Effects of vitamin D, omega-3 fatty acids and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial - (Peer Reviewed Journal)
Bischoff-Ferrari, H.A., Freystatter, G., Vellas, B., Dawson-Hughes, B., Kressig, R.W., Kanis, J.A., Willett, W.C., Manson, J.E., Rizzoli, R., Theiler, R., Hofbauer, L., Ambrecht, G., Da Silva, J., Blauth, M., De Godoi Rezende, C., Lang, W., Siebert, U., Egli, A., Orav, E., Wieczorek, M. 2022. Effects of vitamin D, omega-3 fatty acids and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial. Lancet. https://doi.org/10.1093/ajcn/nqac022.

Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial - (Peer Reviewed Journal)
Dawson-Hughes, B., Wang, J., Barger, K., Bischoff-Ferrari, H.A., Sempos, C.T., Durazo-Arvizu, R.A., Ceglia, L. 2022. Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgac012.

Association of vitamin k with cognitive decline and neuropathology in community-dwelling older persons - (Peer Reviewed Journal)
Booth, S., Shea, K., Barger, K., Leurgans, S.E., James, B.D., Holland, T.M., Agarwal, P., Fu, X., Wang, J., Matuszek, G., Schneider, J. 2022. Association of vitamin k with cognitive decline and neuropathology in community-dwelling older persons. Alzheimer's & Dementia. https://doi.org/10.1002/trc2.12255.

Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the chronic renal insufficiency cohort - (Peer Reviewed Journal)
Shea, K., Barger, K., Booth, S.L., Wang, J., Feldman, H.I., Townsend, R.R., Chen, J., Flack, J., He, J., Jaar, B.G., Kansal, M., Rosas, S.E., Weiner, D.E. 2022. Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the chronic renal insufficiency cohort. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab375.

Vitamin K - (Review Article)
Shea, K., Booth, S.L. 2021. Vitamin K. Advances in Nutrition. https://doi.org/10.1093/advances/nmab133.

Vitamin D: bolus is bogus--a narrative review - (Review Article)
Mazess, R., Bischoff-Ferrari, H., Dawson-Hughes, B. 2021. Vitamin D: bolus is bogus--a narrative review. JBMR Plus. 5(12): e10567. https://doi.org/10.1002/jbm4.10567.

The metabolic roots of senescence: mechanisms and opportunities for intervention - (Review Article)
Wiley, C., Campisi, J. 2021. The metabolic roots of senescence: mechanisms and opportunities for intervention. Nature Metabolism. 3:1290-1301. https://doi.org/10.1038/s42255-021-00483-8.

Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice - (Peer Reviewed Journal)
Ellis, J.L., Fu, X., Karl, P.J., Hernandez, C.J., Mason, J.B., Debose-Boyd, R.A., Booth, S. 2021. Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice. Journal of Nutrition. https://doi.org/10.1093/jn/nxab332.

Sufficient plasma vitamin C is related to greater bone mineral density among postmenopausal women from the Boston Puerto Rican health study - (Peer Reviewed Journal)
Mangano, K.M., Noel, S.E., Dawson-Hughes, B., Tucker, K.L. 2021. Sufficient plasma vitamin C is related to greater bone mineral density among postmenopausal women from the Boston Puerto Rican health study. Journal of Nutrition. https://doi.org/10.1093/jn/nxab291.

Assessment of the performance of the SarQol questionnaire in screening for sarcopenia in older people - (Peer Reviewed Journal)
Geerinck, A., Dawson-Hughes, B., Beaudart, C., Locquet, M., Reginster, J., Bruyer, O. 2021. Assessment of the performance of the SarQol questionnaire in screening for sarcopenia in older people. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-021-01913-z.

Components of the gut microbiome that influence bone tissue-level strength - (Peer Reviewed Journal)
Luna, M., Guss, J., Vasquez-Bolanos, L., Castaneda, M., Vargas Rojas, M., Strong, J.M., Alabi, D.A., Dornevil, S., Nixon, J.C., Taylor, E.A., Donnelly, E., Fu, X., Shea, K., Booth, S.L., Bicalho, R.C., Hernandez, C.J. 2021. Components of the gut microbiome that influence bone tissue-level strength. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4341.

Issues related to the research on vitamin K supplementation and bone mineral density - (Review Article)
Zhang, Y., Shea, K., Judd, S., D'Alton, M., Kahe, K. 2021. Issues related to the research on vitamin K supplementation and bone mineral density. European Journal of Clinical Nutrition. 76:335-339. https://doi.org/10.1038/s41430-021-00941-2.

Cross-calibration of prodigy and horizon a densitometers and precision of the horizon a densitometer - (Peer Reviewed Journal)
Reitshamer, E., Viera, K.B., Shea, K., Dawson-Hughes, B. 2021. Cross-calibration of prodigy and horizon a densitometers and precision of the horizon a densitometer. Journal of Clinical Densitometry. https://doi.org/10.1016/j.jocd.2021.02.003.

Dietary vitamin K is remodeled by gut microbiota and influences community composition - (Peer Reviewed Journal)
Ellis, J.L., Karl, J., Oliverio, A.M., Fu, X., Soares, J.W., Wolfe, B.E., Hernandez, C.J., Mason, J.L., Booth, S.L. 2021. Dietary vitamin K is remodeled by gut microbiota and influences community composition. Gut Microbes. 13(1):1-16. https://doi.org/10.1080/19490976.2021.1887721.

Evidence before enthusiasm: A critical review of the potential cardiovascular benefits of vitamin K - (Review Article)
Shea, K., Berkner, K., Ferland, G., Fu, X., Holden, R., Booth, S.L. 2021. Evidence before enthusiasm: A critical review of the potential cardiovascular benefits of vitamin K. Advances in Nutrition. https://doi.org/10.1093/advances/nmab004.

Vitamin D and Vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project - (Peer Reviewed Journal)
Fu, X., Shea, K., Dolnikowski, G.G., Patterson, W.B., Dawson-Hughes, B., Holland, T.M., Schneider, J.A., Booth, S.L. 2020. Vitamin D and Vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project. Journal of Nutrition. https://doi.org/10.1093/jn/nxaa336.

Controversies in Vitamin D: a statement from the third international conference - (Proceedings)
Giustina, A., Bouillon, R., Binkley, N., Sempos, C.T., Adler, R.A., Bollerslev, J., Dawson-Hughes, B., Ebeling, P.R., Feldman, D., Heijboer, A.C., Jones, G., Kovacs, C.S., Lazaretti-Castro, M., Lips, P., Marcocci, C., Minisola, S., Napoli, N., Rizzoli, R., Scragg, R., White, J.H., Formenti, A., Bilezikian, J. 2020. Controversies in Vitamin D: a statement from the third international conference. JBMR Plus. https://doi.org/10.1002/jbm4.10417.

Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study - (Peer Reviewed Journal)
Dawson-Hughes, B., Staten, M.A., Knowler, W.C., Nelson, J., Vickery, E.M., LeBlanc, E.S., Neff, L.M., Park, J., Pittas, A.G. 2020. Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study. Diabetes Care. https://doi.org/10.2337/dc20-1765.

Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial - (Peer Reviewed Journal)
Bischoff-Ferrari, H.A., Vellas, B., Rizzoli, R., Kressig, R.W., da Silva, J., Blauth, M., Felson, D.T., McCloskey, E., Watzl, B., Hofbauer, L., Felsenberg, D., Willett, W.C., Dawson-Hughes, B., Manson, J.E., Siebert, U., Theiler, R., Stahelin, H.B., de Godoi Rezende Costa, C., Chocano-Bedoya, P.O., Abderhalden, L.A., Egli, A., Kanis, J.A., Orav, J. 2020. Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial. Journal of the American Medical Association. 324(18):1855-1868. https://doi.org/10.1001/jama.2020.16909.

DO-HEALTH: vitamin D3 - omega3 - home exercise - healthy aging and longevity trial - design of a multinational clinical trial on healthy aging among european seniors - (Peer Reviewed Journal)
Bischoff-Ferrara, H.A., De Godoi Rezende Costa Caroline, Rival, S., Vellas, B., Rizzoli, R., Kressig, R.W., Kanis, J.A., Manson, J.E., Dawson-Hughes, B., Orav, E.J., Da Silva, J.A., Blauth, M., Felsenberg, D., Ferrari, S.M., Theiler, R., Egli, A. 2020. DO-HEALTH: vitamin D3 - omega3 - home exercise - healthy aging and longevity trial - design of a multinational clinical trial on healthy aging among european seniors. Contemporary Clinical Trials. 100(2021):106124. https://doi.org/10.1016/j.cct.2020.106124.

Vitamin D supplementation for prevention of type 2 diabetes mellitus. To D or not to D? - (Review Article)
Pittas, A.G., Jorde, R., Kawahara, T., Dawson-Hughes, B. 2020. Vitamin D supplementation for prevention of type 2 diabetes mellitus. To D or not to D? Journal of Clinical Endocrinology and Metabolism. 105(12):3721-3733. https://doi.org/10.1210/clinem/dgaa594.

Acid-base balance of the diet-implications for bone and muscle - (Review Article)
Dawson-Hughes, B. 2020. Acid-base balance of the diet-implications for bone and muscle. European Journal of Clinical Nutrition. 74:7-13. https://doi.org/10.1038/s41430-020-0691-7.

Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial - (Peer Reviewed Journal)
Abderhalden, L.A., Meyer, S., Dawson-Hughes, B., Orav, E.J., Meyer, U., De Godoi Rezenda, C.C., Theiler, R., Stahelin, H.B., Ruschitzka, F., Egli, A., Forman, J.P., Willett, W.C., Bischoff-Ferrari, H.A. 2020. Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqaa145.

Relationship between chronic kidney disease, glucose homeostasis, and plasma osteocalcin carboxylation and fragmentation - (Peer Reviewed Journal)
Kratz, M., Zelnick, L.R., Trenchevska, O., Jeffs, J.W., Borges, C.R., Tseng, H., Booth, S.L., Kestenbaum, B.R., Utzschneider, K.M., De Boer, I.H. 2020. Relationship between chronic kidney disease, glucose homeostasis, and plasma osteocalcin carboxylation and fragmentation. Journal of Renal Nutrition. 31(3):248-256. https://doi.org/10.1053/j.jrn.2020.05.013.

Associations between circulating lipids and fat-soluble vitamins and carotenoids in healthy overweight and obese men - (Peer Reviewed Journal)
Kelly, J.M., Matuszek, G., Van Den Broek, T.J., Huggins, G.S., Smith, C.E., Ordovas, J.M., Wopereis, S., Booth, S.L. 2020. Associations between circulating lipids and fat-soluble vitamins and carotenoids in healthy overweight and obese men. Current Developments in Nutrition. 4(6). https://doi.org/10.1093/cdn/nzaa089.

DASH, mediterranean and alternative healthy eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican osteoporosis study - (Peer Reviewed Journal)
Sabrina, N.E., Mangano, K.M., Mattei, J., Griffith, J.L., Dawson-Hughes, B., Bigornia, S., Tucker, K.L. 2020. DASH, mediterranean and alternative healthy eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican osteoporosis study. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqaa090.

Vitamin K status, cardiovascular disease and all-cause mortality: a participant-level meta-analysis of 3 US cohorts - (Peer Reviewed Journal)
Shea, M., Barger, K., Booth, S.L., Matuszek, G., Cushman, M., Benjamin, E.J., Kritchevsky, S.B., Weiner, D.E. 2020. Vitamin K status, cardiovascular disease and all-cause mortality: a participant-level meta-analysis of 3 US cohorts. American Journal of Clinical Nutrition. 111(6):1170-1177. https://doi.org/10.1093/ajcn/nqaa082.

Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures - (Review Article)
Kanis, J.A., Harvey, N.C., Mccloskey, E., Bruyere, O., Veronese, N., Lorentzon, M., Cooper, C., Rizzoli, R., Adib, G., Al-Daghri, N., Campusano, C., Chandran, M., Dawson-Hughes, B., Javaid, K., Jiwa, F., Johansson, H., Lee, J.K., Liu, E., Messina, O.D., Mkinsi, O., Pinto, D., Prieto-Alhambra, D., Saag, K., Xia, W., Zakraoui, L., Reginster, J. 2019. Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporosis International. https://doi.org/10.1007/s00198-019-05176-3.

The contribution of lipids to the inter-individual response of vitamin K biomarkers to vitamin K supplementation - (Peer Reviewed Journal)
Kelly, J.M., Ordovas, J.M., Matuszek, G.H., Smith, C.E., Huggins, G.S., Dashti, H.S., Ichikawa, R., Booth, S.L. 2019. The contribution of lipids to the inter-individual response of vitamin K biomarkers to vitamin K supplementation. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201900399.

Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial - (Peer Reviewed Journal)
Renerts, K., Fischer, K., Dawson-Hughes, B., Orav, E.J., Freystaetter, G., Simmen, H., Pape, H., Egli, A., Theiler, R., Bischoff-Ferrari, H. 2019. Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial. Quality of Life Research. 28(5):1377-1386. https://doi.org/10.1007/s11136-019-02100-4.

Effect of monthly high-dose vitamin D on mental health in older adults: secondary analysis of a RCT - (Peer Reviewed Journal)
Gugger, A., Marzel, A., Orav, E.J., Willett, W.C., Dawson-Hughes, B., Theiler, R., Freystatter, G., Egli, A., Bischoff-Ferrari, H.A. 2019. Effect of monthly high-dose vitamin D on mental health in older adults: Secondary analysis of a RCT. Journal of the American Geriatrics Society. 67(6):1211-1217. https://doi.org/10.1111/jgs.15808.

Effect of monthly vitamin D on chronic pain among community-dwelling seniors: a randomized, double-blind controlled trial - (Peer Reviewed Journal)
Schlogl, M., Chocano-Bedoya, P., Dawson-Hughes, B., Orav, E.J., Freystaetter, G., Theiler, R., Kressig, R.W., Egli, A., Bischoff-Ferrari, H. 2019. Effect of monthly vitamin D on chronic pain among community-dwelling seniors: a randomized, double-blind controlled trial. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 20(3):356-361. https://doi.org/10.1016/j.jamda.2018.09.004.