Research Project: Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus (FMDV)

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Publications (Clicking on the reprint icon will take you to the publication reprint.)

Inferred Causal Mechanisms of Persistent FMDV Infection from Differential Gene Expression during the Transitional Phase from Acute to Persistent Infection - (Peer Reviewed Journal)
Zhu, J.J., Stenfeldt, C., Bishop, E.A., Canter, J.A., Eschbaumer, M., Rodriguez, L.L., Arzt, J. 2022. Inferred Causal Mechanisms of Persistent FMDV Infection from Differential Gene Expression during the Transitional Phase from Acute to Persistent Infection. Pathogens. 11:8:822. https://doi.org/10.3390/pathogens11080822.

Ecological and Anthropogenic Spatial Gradients Shape Patterns of Dispersal of Foot-and-Mouth Disease Virus - (Peer Reviewed Journal)
Munsey, A., Mwiine, F., Ochwo, S., Velazquez Salinas, L., Ahmed, Z., Rodriguez, L.L., Rieder, A.E., Perez, A., Vanderwaall, K. 2022. Ecological and Anthropogenic Spatial Gradients Shape Patterns of Dispersal of Foot-and-Mouth Disease Virus. Viruses. https://doi.org/10.3390/pathogens11050524.

Impact of mass vaccination on the spatiotemporal dynamics of FMD outbreaks in India, 2008–2016 - (Peer Reviewed Journal)
Gunasekera, U., Biswal, J.K., Machado, G., Ranjan, R., Subramaniam, S., Rout, M., Mohapatra, J.K., Pattnaik, B., Singh, R., Arzt, J. 2022. Spatiotemporal dynamics of foot-and and-mouth disease outbreaks in India, 2008-2016. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.14528.

Parameterization of the durations of phases of foot-and-mouth disease in pigs - (Peer Reviewed Journal)
Moreno-Torres, K., Delgado, A.H., Branan, M.A., Yadav, S., Stenfeldt, C., Arzt, J. 2022. Parameterization of the durations of phases of foot-and-mouth disease in pigs. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2022.105615.

Genome of bovine viral diarrhea virus (BVDV) contaminating a continuous LFBK-aVß6 cell line - (Peer Reviewed Journal)
Holinka-Patterson, L.G., Fish, I., Bertram, M.R., Hartwig, E.J., Smoliga, G.R., Stenfeldt, C., Rodriguez, L.L., Arzt, J. 2022. Genome of bovine viral diarrhea virus (BVDV) contaminating a continuous LFBK-aVß6 cell line. Microbiology Resource Announcements. https://doi.org/10.1128/mra.01167-21.

Molecular surveillance of subclinical foot-and-mouth disease virus infection at slaughterhouses in Vietnam - (Peer Reviewed Journal)
Gunasekera, U., Bertram, M.R., Dung, D.H., Hoang, B.H., Phuong, N.T., Hung, V.V., Dong, P.V., Perez, A., Vanderwaal, K., Arzt, J., Long, N.V., Phan, M., Vu, L.T. 2021. Molecular surveillance of subclinical foot-and-mouth disease virus infection at slaughterhouses in Vietnam. Viruses. https://doi.org/10.3390/v13112203.

Simultaneous and staggered footand-mouth disease virus coinfection of cattle - (Peer Reviewed Journal)
Arzt, J., Bertram, M.R., Fish, I., Smoliga, G.R., Hartwig, E.J., Pauszek, S., Diaz San Segundo, F.C., Sitt, T., Rieder, A.E., Stenfeldt, C. 2021. Simultaneous and staggered footand-mouth disease virus coinfection of cattle. Journal of Virology. https://doi.org/10.1128/JVI.01650-21.

The risk and mitigation of foot-and-mouth disease virus infection of pigs through consumption of contaminated feed - (Abstract Only)

Estimation of Foot-and-Mouth Disease windborne transmission risk from USA beef feedlots - (Peer Reviewed Journal)
Arzt, J., Coffman, M., Sanderson, M.W., Dodd, C.C., Renter, D.G. 2021. Estimation of Foot-and-Mouth Disease windborne transmission risk from USA beef feedlots. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2021.105453.

The risk and mitigation of foot-and-mouth disease virus infection of pigs through consumption of contaminated feed - (Peer Reviewed Journal)
Stenfeldt, C., Bertram, M.R., Crocket, H., Hartwig, E.J., Smoliga, G.R., Niederwerder, M., Diel, D., Dee, S., Arzt, J. 2021. The risk and mitigation of foot-and-mouth disease virus infection of pigs through consumption of contaminated feed. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.14230.

Detection of foot-and-mouth disease (FMD) virus in healthy cattle and buffalo at Southeast Asian slaughterhouses - (Peer Reviewed Journal)
Buckle, K., Bueno, R., Mcfadden, A., Van Andel, M., Spence, R., Abila, R., Verin, B., Khounsey, S., Ludi, A., Arzt, J. 2021. Detection of foot-and-mouth disease (FMD) virus in healthy cattle and buffalo at Southeast Asian slaughterhouses. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.691308.

An Adventitious agent free clonal cell line that is highly susceptible to foot and mouth disease virus - (Peer Reviewed Journal)
Larocco, M., Krug, P., Ahmed, Z., Rodriguez-Calzada1, M., Azzinaro, P.A., Rodriguez, L.L., De Los Santos, T.B., Medina, G.N. 2021. An Adventitious agent free clonal cell line that is highly susceptible to foot and mouth disease virus. Journal of Clinical Microbiology. https://doi.org/10.1016/j.biologicals.2021.05.003.

Tracking the dispersal of foot-and-mouth disease virus serotype O in East Africa using phylodynamics - (Peer Reviewed Journal)
Munsey, A., Mwiine, F., Ochwo, S., Velazquez Salinas, L., Ahmed, Z., Maree, F., Rodriguez, L.L., Rieder, A.E., Perez, A., Vanderwaall, K., Dellicour, S. 2021. Tracking the dispersal of foot-and-mouth disease virus serotype O in East Africa using phylodynamics. Molecular Ecology. https://doi.org/10.1111/mec.15991.

Use of Protein Pegylation to prolong the antiviral effect of IFN against FMDV - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Medina, G.N., Mogulothu, A., Azzinaro, P.A., Attreed, S.E., Gutkoska, J.R., Lombardi, K.R., Shields, J., Hudock, T.A., De Los Santos, T.B. 2021. Use of Protein Pegylation to prolong the antiviral effect of IFN against FMDV. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2021.668890.

Use of synonymous deoptimization for the development of modified live attenuated strains of foot and mouth disease virus - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Medina, G., Spinard, E., Kloc, A., Ramirez-Medina, E., Azzinaro, P.A., Mueller, S., Rieder, A.E., De Los Santos, T.B. 2021. Use of synonymous deoptimization for the development of modified live attenuated strains of foot and mouth disease virus. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2020.610286.

Novel recombinant foot-and-mouth disease virus circulating in Vietnam - (Other)
Bertram, M.R., Brito, B., Palinski, R., Fish, I., Pauszek, S., Hartwig, E.J., Smoliga, G.R., Vu, L.T., Dung, D.H., Arzt, J., Hoang, B.H., Phuong, N.T., Vu, P.P., Dung, N.K., Tien, N.N., Dong, P.V. 2021. Novel recombinant foot-and-mouth disease virus circulating in Vietnam. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.01263-20.

Evaluation in swine of a recombinant African swine fever virus lacking the MGF-360-1L gene - (Peer Reviewed Journal)
Ramierez-Medina, E., Vuono, E., Rai, A., Pruitt, S.E., Silva, E., Velazquez-Salinas, L., Zhu, J.J., Gladue, D.P., Borca, M.V. 2020. Evaluation in swine of a recombinant African swine fever virus lacking the MGF-360-1L gene. Viruses. https://doi.org/10.3390/v12101193.

Novel Foot-and-Mouth Disease vaccine platform:Formulations for safe and DIVA-compatible FMD vaccines with improved potency - (Peer Reviewed Journal)
Hardham, J., Krug, P., Pacheco, J., Thompson, J., Domanowski, P., Gay, C.G., Rodriguez, L.L., Rieder, A.E. 2020. Novel Foot-and-Mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Frontiers in Veterinary Science. https://doi.org/https://doi.org/10.3389/fvets.2020.554305.

Diagnostic and epitope mapping potential of single-chain antibody fragments against foot-and-mouth disease serotype A, SAT1 and SAT3 viruses - (Peer Reviewed Journal)
Chitray, M., Opperman, P., Rotherham, L., Fehrsen, J., Frischmuth, J., Rieder, A.E., Maree, F. 2020. Diagnostic and epitope mapping potential of single-chain antibody fragments against foot-and-mouth disease serotype A, SAT1 and SAT3 viruses. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00475.

Use of IFN-based biotherapeutics to harness the host against foot-and-mouth disease - (Peer Reviewed Journal)
Medina, G., De Los Santos, T.B., Diaz San Segundo, F.C. 2020. Use of IFN-based biotherapeutics to harness the host against foot-and-mouth disease. Frontiers in Microbiology. https://doi.org/https://doi.org/10.3389/fvets.2020.00465.

Residues within the foot-and-mouth disease virus 3dpol nuclear localization signal affect polymerase fidelity - (Peer Reviewed Journal)
Kloc, A., Rai, D.K., Kenney, M.A., Schafer, E.A., Rieder, A.E., Gladue, D. 2020. Residues within the foot-and-mouth disease virus 3dpol nuclear localization signal affect polymerase fidelity. Journal of Virology. https://doi.org/10.1128/JVI.00833-20.

Mechanisms of Foot-and-Mouth Disease virus persistence inferred from immune-related genes differentially expressed between pharyngeal epithelia of virus carriers and non-carriers - (Peer Reviewed Journal)
Zhu, J.J., Stenfeldt, C., Bishop, E., Canter, J.C., Eschbaumer, M., Rodriguez, L.L., Arzt, J. 2020. Mechanisms of Foot-and-Mouth Disease virus persistence inferred from immune-related genes differentially expressed between pharyngeal epithelia of virus carriers and non-carriers. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00340.

Duration of Contagion of FMDV in Infected Live Pigs and Carcasses - (Peer Reviewed Journal)
Stenfeldt, C., Bertram, M., Smoliga, G.R., Hartwig, E.J., Delgado, A., Arzt, J. 2020. Duration of Contagion of FMDV in Infected Live Pigs and Carcasses. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00334.

Extinction dynamics of the foot-and-mouth disease virus carrier state under natural conditions - (Peer Reviewed Journal)
Bertram, M.R., Yadav, S., Delgado, A., Arzt, J. 2020. Extinction dynamics of the foot-and-mouth disease virus carrier state under natural conditions. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00276.

Impairment of the deISGylation activity of foot-and-mouth disease Lpro causes viral attenuation without affecting interferon expression during viral infection. - (Peer Reviewed Journal)
Medina, G., Azzinaro, P.A., Ramirez-Medina, E., Gutkoska, J.R., Fang, De Los Santos, T.B. 2020. Impairment of the deISGylation activity of foot-and-mouth disease Lpro causes viral attenuation without affecting interferon expression during viral infection. Virology. https://doi.org/10.1128/JVI.00341-20.

Genome sequences of 7 foot-and-mouth disease virus isolates reveal diversity in the O/ME-SA/Ind2001 lineage in India between - (Other)
Bertram, M., Palinski, R., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Biswal, J.K., Ranjan, R., Subramaniam, S., Mohapatra, J.K., Arzt, J., Das, B., Fish, I.H., Pattanaik, B. 2020. Genome sequences of 7 foot-and-mouth disease virus isolates reveal diversity in the O/ME-SA/Ind2001 lineage in India between. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.00287-20.

Swine host protein coiled-coil domain containing 115 (CCDC115) interacts with classical swine fever virus structural glycoprotein E2 during virus - (Peer Reviewed Journal)
Vuonno, E., Ramirez-Media, E., Berggren, K., Rai, A., Pruitt, S., Silva, E., Velazquez-Salinas, L., Gladue, D.P., Borca, M.V. 2020. Swine host protein coiled-coil domain containing 115 (CCDC115) interacts with classical swine fever virus structural glycoprotein E2 during virus. Viruses. https://doi.org/10.3390/v12040388.

Into the deep (sequence) of the foot-and-mouth disease virus gene pool: population bottlenecks and adaptation during infection in naïve and vaccinated cattle - (Peer Reviewed Journal)
Fish, I., Stenfeldt, C., Palinski, R.M., Pauszek, S.J., Arzt, J. 2020. Into the deep (sequence) of the foot-and-mouth disease virus gene pool: population bottlenecks and adaptation during infection in naïve and vaccinated cattle. mSphere. https://doi.org/10.3390/pathogens9030208.

Genetic diversity of circulating foot and mouth 1 disease virus in Uganda cross-sectional study during 2014-2017 - (Database / Dataset)
Velazquez-Salinas, L., Mwiine, F.N., Ahmed, Z., Ochwo, S., Munsey, A., Lutwama, J.J., Vanderwaal, K., Perez, A., Rieder, A.E. 2020. Genetic diversity of circulating foot and mouth 1 disease virus in Uganda cross-sectional study during 2014-2017. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00162.

The role of African buffalo in the epidemiology of foot-and-mouth disease in sympatric cattle and buffalo populations in Kenya - (Peer Reviewed Journal)
Omondi, G., Gakuya, F., Arzt, J., Sangula, A., Hartwig, E.J., Pauszek, S.J., Smoliga, G.R., Brito, B.P., Perez, A., Obanda, V., Vanderwaal, K. 2020. The role of African buffalo in the epidemiology of foot-and-mouth disease in sympatric cattle and buffalo populations in Kenya. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.13573.

The carrier conundrum; a review of recent advances and persistent gaps regarding the carrier state of foot-and-mouth disease virus - (Review Article)
Arzt, J., Stenfeldt, C. 2020. The carrier conundrum; a review of recent advances and persistent gaps regarding the carrier state of foot-and-mouth disease virus. Pathogens. https://doi.org/10.3390/pathogens9030167.

Foot-and-Mouth Disease Virus Lacking the Leader Protein and Containing Two Negative DIVA Markers (FMDV A24 LL3B3D) Is Fully Attenuated in Pigs - (Peer Reviewed Journal)
Eschbaumer, M., Dill, V., Carlson, J.C., Arzt, J., Stenfeldt, C., Krug, P., Hardham, J., Stegner, J.E., Rodriguez, L.L., Rieder, A.E. 2020. Foot-and-Mouth Disease Virus Lacking the Leader Protein and Containing Two Negative DIVA Markers (FMDV A24 LL3B3D) Is Fully Attenuated in Pigs. Pathogens. https://doi.org/10.3390/pathogens9020129.

Foot-and-mouth disease virus serotype O/CATHAY near full-length genomes from 5 outbreaks in Vietnam, 2017-2019 - (Database / Dataset)
Vierra, D., Bertman, M., Palinski, R.M., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Le, V.T., Bui, H.H., Nguyen, P.T., Pham, D.V., Nguyen, T.N., Do, D.H., Arzt, J. 2020. Foot-and-mouth disease virus serotype O/CATHAY near full-length genomes from 5 outbreaks in Vietnam, 2017-2019. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.01315-19.

Characterization of transboundary foot-and-mouth disease viruses in Nigeria and Cameroon during 2016 - (Peer Reviewed Journal)
Ehizibolo, D.O., Fish, I., Brito, B., Bertram, M.R., Ularamu, H., Lazarus, D., Wungak, Y., Smoliga, G.R., Hartwig, E.J., Pauszek, S.J., Dickmu, S., Abdoulkadiri, S., Arzt, J. 2019. Characterization of transboundary foot-and-mouth disease viruses in Nigeria and Cameroon during 2016. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.13461.

Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine. - (Abstract Only)
Borca, M.V., Ramirez Media, E., Silva, E., Vuono, E., Rai, A., Pruitt, S., Holinka, L., Velazquezsalinas, L., Gladue, D.P., Risatti, G., Shi, J. 2020. Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine.. Meeting Abstract. https://doi.org/10.1038/s41598-020-57455-3.

Genome sequences of foot-and-mouth disease virus SAT 1 topotype X from Cameroon - (Other)
Bertram, M.R., Dickmu, S., Palinski, R.M., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vierra, D., Abdoulkadiri, S., Arzt, J. 2019. Genome sequences of foot-and-mouth disease virus SAT 1 topotype X from Cameroon. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.

Foot-and-mouth disease virus serotype A complete genome sequence from Kenya in 2016 - (Review Article)

Spatial distribution and risk factors for foot and mouth disease virus in Uganda: Opportunities for strategic surveillance - (Peer Reviewed Journal)
Munsey, A., Mwiine, F., Ochwo, S., Velazquez-Salinas, L., Admed, Z., Maree, F.F., Rodriguez, L.L., Rieder, A.E., Perez, A., Vanderwaal, K. 2019. Spatial distribution and risk factors for foot and mouth disease virus in Uganda: Opportunities for strategic surveillance. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2019.104766.

Duration of protection and humoral immunity induced by an adenovirus-vectored subunit vaccine for foot-and-mouth disease (FMD) in Holstein steers - (Abstract Only)
Sitt, T., Keeney, M., Barrera, J., Pandya, M., Eckstrom, K., Warner, M., Pacheco, J., Larocco, M., Palarea-Albaladejo, J., Brake, D., Rieder, A.E., Arzt, J., Barlow, J., Golde, W. 2019. Duration of protection and humoral immunity induced by an adenovirus-vectored subunit vaccine for foot-and-mouth disease (FMD) in Holstein steers. Meeting Abstract. https://doi.org/10.1016/j.vaccine.2019.08.017.

Duration of protection and immunity induced by an adenovirus- vectored foot-and-mouth disease virus serotype A24 subunit vaccine in Holstein steers - (Peer Reviewed Journal)

First report of near-complete genome sequences of foot-and-mouth disease virus serotype O strains from Kenya - (Other)
Palinski, R.M., Sangula, A., Bertram, M.R., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Obanda, V., Omondi, G., Vanderwaal, K., Arzt, J. 2019. First Report of Near-Complete Genome Sequences of Footand- Mouth Disease Virus Serotype O Strains from Kenya. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.00808-19.

First report of near-complete genome sequences of foot-and-mouth disease virus serotype O strains from Kenya - (Other)
Fish, I., Vierra, D., Ehzibolo, D., Palinski, R.M., Bertram, M., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Arzt, J. 2019. First report of near-complete genome sequences of foot-and-mouth disease virus serotype O strains from Kenya. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.00808-19.

Parameterization of the durations of phases of foot-and-mouth disease in cattle - (Peer Reviewed Journal)
Yadav, S., Stenfeldt, C., Branan, M.A., Moreno-Torres, K.I., Holmstrom, L., Delgado, A.H., Arzt, J. 2019. Parameterization of the durations of phases of foot-and-mouth disease in cattle. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2019.00263.

Genome sequences of 18 foot-and-mouth disease virus outbreak strains of serotype O sublineage Ind2001d from India 2013-2014 - (Review Article)
Bertman, M.R., Palinski, R.M., Ranjan, R., Biswal, J.K., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vierra, D., Fish, I.H., Subramaniam, S., Mohapatra, J.K., Das, B., Pattnaik, B., Arzt, J. 2019. Genome sequences of 18 foot-and-mouth disease virus outbreak strains of serotype O sublineage Ind2001d from India 2013-2014. Microbiology Resource Announcements. http://www.doi.org/10.1128/MRA.00776-19.

The VP1 G-H loop hypervariable epitope contributes to protective immunity against foot and mouth disease virus in swine - (Peer Reviewed Journal)
Fernandez-Sainz, I., Gavitt, T.D., Koster, M., Ramirez-Medina, E., Rodriguez, Y.Y., Wu, P., Silbart, L.K., De Los Santos, T.B., Szczepanek, S.M. 2019. The VP1 G-H loop hypervariable epitope contributes to protective immunity against foot and mouth disease virus in swine. Vaccine. https://doi.org/10.1016/j.vaccine.2019.05.019.

Phylogeographic and cross-species transmission dynamics of SAT1 and SAT2 foot-and-mouth disease virus in Eastern Africa - (Peer Reviewed Journal)
Omondi, G., Alkhamis, M., Obanda, V., Gakuya, F., Sangula, A., Pauszek, S.J., Perez, A., Ngulu, S., Van Aardt, R., Arzt, J., Vanderwaal, K. 2019. Phylogeographic and cross-species transmission dynamics of SAT1 and SAT2 foot-and-mouth disease virus in Eastern Africa. Molecular Ecology. https://doi.org/10.1111/mec.15125.

Foot-and-mouth disease in a limited number of experimentally infected mule deer (Odocoileus hemionus) - (Peer Reviewed Journal)
Rhyan, J., Mccollum, M., Gidlewski, T., Shalev, M., Ward, G., Donahue, B., Arzt, J., Stenfeldt, C., Mohamed, F., Nol, P., Deng, M., Metwally, S., Salman, M. 2020. Foot-and-mouth disease in a limited number of experimentally infected mule deer (Odocoileus hemionus). Journal of Wildlife Diseases. https://doi.org/10.7589/2019-03-059.

Serological and phylogenetic characterization of foot and mouth disease viruses from Uganda during cross sectional surveillance study in cattle between 2014 and 2017 - (Peer Reviewed Journal)
Mwiine, F.N., Velazquez-Salinas, L., Ahmed, Z., Ochwo, S., Munsey, A., Kenney, M.A., Lutwama, J.J., Maree, F.F., Lobel, L., Perez, A.M., Rodriguez, L.L., Vanderwaal, K., Rieder, A.E. 2019. Serological and phylogenetic characterization of foot and mouth disease viruses from Uganda during cross sectional surveillance study in cattle between 2014 and 2017. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.13249.

The evolution of a super-swarm of foot-and-mouth disease virus in cattle - (Peer Reviewed Journal)
Arzt, J., Fish, I., Pauszek, S.J., Johnson, S.L., Chain, P.S., Rai, D.K., Rieder, A.E., Goldberg, T.L., Rodriguez, L.L., Stenfeldt, C. 2019. The evolution of a super-swarm of foot-and-mouth disease virus in cattle. Virology. https://doi.org/10.1371/journal.pone.0210847.

Genetic and antigenic variation of foot-and-mouth disease virus during persistent infection in naturally infected cattle and Asian buffalo in India - (Peer Reviewed Journal)
Biswal, J.K., Ranjan, R., Subramaniam, S., Mohapatra, J.K., Sharma, M.K., Bertram, M.R., Brito, B., Rodriguez, L.L., Pattnaik, B., Arzt, J. 2019. Genetic and antigenic variation of foot-and-mouth disease virus during persistent infection in naturally infected cattle and Asian buffalo in India. bioRxiv. https://doi.org/10.1371/journal.pone.0214832.

Quantitative impacts of incubation phase transmission of foot-and-mouth disease virus - (Peer Reviewed Journal)
Arzt, J., Branan, M., Delgado, A., Yadav, S., Moreno-Torres, K., Tildesley, M., Stenfeldt, C. 2019. Quantitative impacts of incubation phase transmission of foot-and-mouth disease virus. Scientific Reports. https://doi.org/10.1038/s41598-019-39029-0.

First genome sequence of Foot-and-mouth disease virus serotype O sublineage Ind2001e from Vietnam - (Peer Reviewed Journal)
Palinski, R., Bertram, M.R., Vu, L.T., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Stenfeldt, C., Fish, I.H., Hoang, B.H., Dung, D.H., Arzt, J. 2019. First genome sequence of Foot-and-mouth disease virus serotype O sublineage Ind2001e from Vietnam. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.01424-18.

First detection of Senecavirus A in Vietnam - (Peer Reviewed Journal)
Arzt, J., Bertram, M.R., Vu, L.T., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Palinski, R., Stenfeldt, C., Fish, I.H., Hoang, B.H., Dung, D.H. 2019. First detection of Senecavirus A in Vietnam. Emerging Infectious Diseases. https://doi.org/10.1128/MRA.01247-18.

Molecular epidemiology of foot-and-mouth disease virus in the context of transboundary animal movement in the far north region of Cameroon - (Peer Reviewed Journal)
Bertram, M., Bravo De Rueda, C., Garabed, R., Dickmu Jumbo, S., Moritz, M., Pauszek, S.J., Abdoulkadiri, S., Rodriguez, L.L., Arzt, J. 2018. Molecular epidemiology of foot-and-mouth disease virus in the context of transboundary animal movement in the far north region of Cameroon. Frontiers in Veterinary Infectious Diseases. https://doi.org/10.3389/fvets.2018.00320.

Contact challenge of cattle with foot-and-mouth disease virus validates the role of the nasopharyngeal epithelium as the site of primary and persistent infection. - (Peer Reviewed Journal)
Stenfeldt, C., Smoliga, G.R., Hartwig, E.J., Palinski, R., Fish, I.H., Silva, E.B., Pauszek, S.J., Arzt, J. 2018. Contact challenge of cattle with foot-and-mouth disease virus validates the role of the nasopharyngeal epithelium as the site of primary and persistent infection. Scientific Reports. https://doi.org/10.1128/mSphere.00493-18.

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80 - (Peer Reviewed Journal)
Chen, X., Gaglione, R., Leong, T., Bednor, L., De los Santos, T.B., Luk, E., Airola, M., Hollingsworth, N.M. 2018. Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1007832.

FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation - (Peer Reviewed Journal)
Visser, L.J., Medina, G.N., Rabouw, H.H., De Groot, R.J., Langereis, M.A., De los Santos, T.B., Van Kuppeveld, F.J. 2018. FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology. https://doi.org/10.1128/JVI.00922-18.

The different tactics of foot-and-mouth disease virus to evade innate immunity - (Peer Reviewed Journal)
Medina, G.N., Diaz San-Segundo, F., Stenfeldt, C., Arzt, J., De los Santos, T.B. 2018. The different tactics of foot-and-mouth disease virus to evade innate immunity. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.02644.

The development and validation of a novel nanobody-based competitive ELISA for the detection of foot and mouth disease 3ABC antibodies in cattle - (Peer Reviewed Journal)
Gelkop, S., Sobarzo, A., Brangel, P., Vincke, C., Romao, E., Fedida-Metula, S., Strom, N., Ataliba, I., Mwiin, F.N., Ochwo, S., Velazquez-Salinas, L., McKendry, R.A., Muyldermans, S., Lutwama, J.J., Rieder, A.E., Yavelsky, V., Lobel, L. 2018. The development and validation of a novel nanobody-based competitive ELISA for the detection of foot and mouth disease 3ABC antibodies in cattle. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2018.00250.

Transmission of foot-and-mouth disease from persistently infected carrier cattle to naive cattle via transfer of oropharyngeal fluid - (Peer Reviewed Journal)
Arzt, J., Belsham, G.J., Lohse, L., Botner, A., Stenfeldt, C. 2018. Transmission of foot-and-mouth disease from persistently infected carrier cattle to naive cattle via transfer of oropharyngeal fluid. mSphere. 3(5):e00365-18. https://doi.org/10.1128/mSphere.00365-18.

Lack of transmission of foot-and-mouth disease virus from persistently infected cattle to naïve cattle under field conditions in Vietnam - (Peer Reviewed Journal)
Bertram, M.R., Vu, L.T., Pauszek, S.J., Brito, B.P., Hartwig, E.J., Smoliga, G.R., Hoang, B.H., Phuong, N.T., Stenfeldt, C., Fish, I.H., Hung, V.V., Delgado, A., VanderWaal, K., Rodriguez, L.L., Long, N.T., Dung, D.H., Arzt, J. 2018. Lack of transmission of foot-and-mouth disease virus from persistently infected cattle to naïve cattle under field conditions in Vietnam. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2018.00174.

Foot-and-mouth disease infection dynamics in contact-exposed pigs are determined by the estimated exposure dose - (Peer Reviewed Journal)
Moreno-Torres, K.I., Brito, B.P., Branan, M.A., Rodriguez, L.L., Delgado, A.H., Stenfeldt, C., Arzt, J. 2018. Foot-and-mouth disease infection dynamics in contact-exposed pigs are determined by the estimated exposure dose. Frontiers in Veterinary Science. 5:167. https://doi.org/10.3389/fvets.2018.00167.

Characterization of naturally occurring, new and persistent subclinical foot-and-mouth disease virus infection in vaccinated Asian buffalo in Islamabad Capital Territory, Pakistan - (Peer Reviewed Journal)
Farooq, U., Ahmed, Z., Naeem, K., Bertram, M., Brito, B., Stenfeldt, C., Pauszek, S.J., Larocco, M.A., Arzt, J., Rodriguez, L.L. 2018. Characterization of naturally occurring, new and persistent subclinical foot-and-mouth disease virus infection in vaccinated Asian buffalo in Islamabad Capital Territory, Pakistan. Veterinary Research. https://doi.org/10.1111/tbed.12963.

A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences - (Peer Reviewed Journal)
Brito, B.P., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, L.T., Vu, P.P., Stenfeldt, C., Rodriguez, L.L., King, D.P., Knowles, N.J., Bachanek-Bankowska, K., Long, N.T., Dung, D.H., Arzt, J. 2018. A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences. Scientific Reports. 8:6472. https://doi.org/10.1038/s41598-018-24870-6.

Effect of vaccination on cattle herds previously exposed to foot and mouth disease in Cameroon - (Peer Reviewed Journal)
Bertram, M.R., Delgado, A., Pauszek, S.J., Smoliga, G.R., Brito, B.P., Stenfeldt, C., Hartwig, E.J., Dickmu-Jumbo, S., Abdoulmoumini, M., Abona Olivia, A., Salhine, R., Rodriguez, L.L., Gerabed, R., Arzt, J. 2018. Effect of vaccination on cattle herds previously exposed to foot and mouth disease in Cameroon. Preventive Veterinary Medicine. 155:1-10. https://doi.org/10.1016/j.prevetmed.2018.04.003.

The need for improved vaccines against foot-and-mouth disease - (Peer Reviewed Journal)
De Los Santos, T.B., Diaz-San Segundo, F., Rodriguez, L.L. 2018. The need for improved vaccines against foot-and-mouth disease. Current Opinion in Virology. 29:16-25. https://doi.org/10.1016/j.coviro.2018.02.005.

The roles of picornavirus untranslated regions in infection and innate immunity - (Review Article)
Kloc, A., Rai, D.K., Rieder, A.E. 2018. The roles of picornavirus untranslated regions in infection and innate immunity. Frontiers in Microbiology. 20(9):485. https://doi.org/10.3389/fmicb.2018.00485.

An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus - (Peer Reviewed Journal)
Chung, C.J., Clavijo, A., Bounpheng, M., Uddowla, S., Sayed, A., Dancho, B., Olesen, I.C., Pacheco, J., Kamicker, B.J., Brake, D.A., Bandaranayaka-Mudiyanselage, C., Lee, S.S., Rai, D.K., Rieder, A.E. 2018. An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus. Journal of Veterinary Diagnostic Investigation. 30(5):699-707. https://doi.org/10.1177/1040638718779641.

A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection - (Peer Reviewed Journal)
Stenfeldt, C., Arzt, J., Pacheco, J., Gladue, D.P., Smoliga, G.R., Silva, E., Rodriguez, L.L., Borca, M.V. 2018. A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection. Virology. 516:115-126. https://doi.org/10.1016/j.virol.2018.01.008.

Clearance of a persistent Picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses - (Peer Reviewed Journal)
Stenfeldt, C., Eschbaumer, M., Smoliga, G.R., Rodriguez, L.L., Zhu, J.J., Arzt, J. 2017. Clearance of a persistent Picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses. Scientific Reports. 7:17800. https://doi.org/10.1038/s41598-017-18112-4.

Foot-and-mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India - (Peer Reviewed Journal)
Hayder, S.S., VanderWaal, K., Ranjan, R., Biswal, J.K., Subramaniam, S., Mohapatra, J.K., Sharma, G.K., Rout, M., Dash, B., Das, B., Prusty, B., Sharma, A.K., Stenfeldt, C., Perez, A., Rodriguez, L.L., Arzt, J. 2017. Foot-and-mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India. Transboundary and Emerging Diseases. 65(2):e404-e415. https://doi.org/10.1111/tbed.12774.

Genetic diversity and comparison of diagnostic tests for characterization of foot-and-mouth disease virus strains from Pakistan 2008-2012 - (Peer Reviewed Journal)
Ahmed, Z., Pauszek, S.J., Ludi, A., Larocco, M.A., Khan, E., Afzal, M., Arshed, M.J., Farooq, U., Arzt, J., Bertram, M., Brito, B., Naeem, K., Abubakar, M., Rodriguez, L.L. 2017. Genetic diversity and comparison of diagnostic tests for characterization of foot-and-mouth disease virus strains from Pakistan 2008-2012. Transboundary and Emerging Diseases. 65(2):534-546. https://doi.org/10.1111/tbed.12737.

Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells - (Peer Reviewed Journal)
Kloc, A., Diaz-San Segundo, F., Schafer, E.A., Rai, D.K., Kenney, M.A., De Los Santos, T.B., Rieder, A.E. 2017. Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells. Virology. 512:132-143.

Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam - (Peer Reviewed Journal)
Pauszek, S.J., Bertram, M.R., Vu, L.T., Hartwig, E.J., Smoliga, G.R., Brito, B., Stenfeldt, C., Hung, N.T., Hoang, B.H., Rodriguez, L.L., Dung, D.H., Arzt, J. 2017. Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam. Genome Announcements. 5:e00849-17. https://doi.org/10.1128/genomeA.00849-17.

Enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (FMDV) capsids - (Peer Reviewed Journal)
Kenney, M.A., Waters, R.A., Rieder, A.E., Pega, J., Perez-Filguera, M., Golde, W.T. 2017. Enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (FMDV) capsids. Journal of Immunological Methods. 450:1-9. https://doi.org/10.1016/j.jim.2017.07.001.

Differential replication of foot-and-mouth disease viruses in mice determine lethality - (Peer Reviewed Journal)
Cacciabue, M., Garcia-Nunez, M.S., Delgado, F., Curra, A., Marrero, R., Molinari, P., Rieder, A.E., Carrillo, E., Gismondi, M.I. 2017. Differential replication of foot-and-mouth disease viruses in mice determine lethality. Virology. 509:195-204. doi: 10.1016/j.virol.2017.06.012.

Oncolytic recombinant vesicular stomatitis virus (VSV) is nonpathogenic and non-transmissible in pigs, a natural host of VSV - (Peer Reviewed Journal)
Velazquez-Salinas, L., Niak, S., Peng, K., Pauszek, S.J., Rodriguez, L.L. 2017. Oncolytic recombinant vesicular stomatitis virus (VSV) is nonpathogenic and non-transmissible in pigs, a natural host of VSV. Human Gene Therapy. 28(2):108-115.

Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity - (Peer Reviewed Journal)
Rai, D.K., Diaz-San Segundo, F., Campagnola, G., Schafer, E.A., Kloc, A., Keith, A., De Los Santos, T.B., Peersen, O., Rieder, A.E. 2017. Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity. Journal of Virology. doi: 10.1128/JVI.00081-17.

Pathogenesis of virulent and attenuated foot and mouth disease virus in cattle - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Stenfeldt, C., Rodriguez, L.L. 2017. Pathogenesis of virulent and attenuated foot and mouth disease virus in cattle. Virology. 14(1):89. doi: 10.1186/s12985-017-0758-9.

Disinfection of transboundary animal disease viruses on surfaces in pork packing plants - (Peer Reviewed Journal)
Krug, P.W., Davis, T., O'Brien, C.C., LaRocco, M.A., Rodriguez, L.L. 2018. Disinfection of transboundary animal disease viruses on surfaces in pork packing plants. Veterinary Microbiology. 219:219-225.

First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam - (Peer Reviewed Journal)
Vu, L.T., Long, N.T., Brito, B., Stenfeldt, C., Phuong, N.T., Hoang, B.H., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, P.P., Quang, L.T., Hung, V.V., Tho, N.D., Dong, P.V., Minh, P.Q., Bertram, M.R., Fish, I.H., Rodriguez, L.L., Dung, D.H., Arzt, J. 2017. First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam. PLoS One. 12(6):e0177361. https://doi.org/10.1371/journal.pone.0177361.

Insights into jumonji c-domain containing protein 6 (JMJD6): a multifactorial role in FMDV replication in cells - (Review Article)
Lawrence, P.J., Rieder, A.E. 2017. Insights into jumonji c-domain containing protein 6 (JMJD6): a multifactorial role in FMDV replication in cells. Virus Genes. 53(3):340-351.

Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle - (Peer Reviewed Journal)
Sreenivasa, B.P., Mohapatra, J.K., Pauszek, S.J., Koster, M.J., Dhanya, V.C., Tamil Selvan, R.P., Hosamani, M., Saravanan, P., Basagoudanavar, S.H., De Los Santos, T.B., Venkataramanan, R., Rodriguez, L.L., Grubman, M.J. 2017. Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle. Veterinary Microbiology. 203:196-201. doi: 10.1016/j.vetmic.2017.03.019.

Genome sequence of foot-and-mouth disease virus serotype O lineage ind-2001d collected in Vietnam in 2015 - (Peer Reviewed Journal)
Arzt, J., Brito, B.P., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, L.T., Vu, P.P., Stenfeldt, C., Rodriguez, L.L., Long, N.T., Dung, D.H. 2017. Genome sequence of foot-and-mouth disease virus serotype O lineage ind-2001d collected in Vietnam in 2015. Genome Announcements. 5(18):e00223-17. doi: 10.1128/genomeA.00223-17.

Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication - (Peer Reviewed Journal)
Medina, G.N., Knudsen, G.M., Greninger, A.L., Kloc, A., Diaz-San Segundo, F., Rieder, A.E., Grubman, M., Derisi, J.L., De Los Santos, T.B. 2017. Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication. Virology. 505:12-22. doi: 10.1016/j.virol.2017.02.010.

Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection - (Peer Reviewed Journal)
Gutkoska, J., Larocco, M.A., Ramirez-Medina, E., De Los Santos, T.B., Lawrence, P.J. 2017. Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection. Virology. doi: 10.1016/j.virol.2017.01.019.