Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Sarcopenia: an emerging syndrome of advancing age - (Review Article)
Fielding, R. 2024. Sarcopenia: an emerging syndrome of advancing age. Calcified Tissues International. https://doi.org/10.1007/s00223-023-01175-z.

A critical review of current worldwide definitions of sarcopenia - (Review Article)
Fielding, R.A., Alhmly, H. 2023. A critical review of current worldwide definitions of sarcopenia. Calcified Tissue International. https://doi.org/10.1007/s00223-023-01163-3.

Biomarkers of cellular senescence and risk of death in humans - (Peer Reviewed Journal)
St. Sauver, J.L., Weston, S.A., Atkinson, E.J., Mc Gree, M.M., Mielke, M.M., White, T.A., Heeren, A.A., Olson, J.E., Rocca, W.A., Palmer, A.K., Cummings, S.R., Fielding, R., Bielinski, S.J., Lebrasseur, N.K. 2023. Biomarkers of cellular senescence and risk of death in humans. Aging Cell. https://doi.org/10.1111/acel.14006.

Structured moderate exercise and biomarkers of kidney health in sedentary older adults: the lifestyle interventions and independence for elders randomized clinical trial - (Peer Reviewed Journal)
Sheshandri, A., Lai, M., Hsu, F., Bauer, S., Chen, S., Tse, W., Jotwani, V., Tranah, G.J., Lai, J.C., Hallan, S., Fielding, R., Liu, C.K., Li, J.H., Coca, S.G., Shlipak, M.G. 2023. Structured moderate exercise and biomarkers of kidney health in sedentary older adults: The lifestyle interventions and independence for elders randomized clinical trial. Kidney Medicine. https://doi.org/10.1016/j.xkme.2023.100721.

Outcomes for regulatory approval in geriatrics: embracing loss of mobility and mobility disability as clinically meaningful therapeutic indications - (Other)
Fielding, R., Lebrasseur, N.K. 2023. Outcomes for regulatory approval in geriatrics: embracing loss of mobility and mobility disability as clinically meaningful therapeutic indications. Journal of Nutrition Health and Aging. https://doi.org/10.1007/s12603-023-1944-7.

Geriatric syndromes and health-related quality of life in older adults with chronic kidney disease: ancillary analysis of the award randomized clinical trial - (Peer Reviewed Journal)
Liu, C.K., Miao, S., Giffuni, J., Katzel, L., Fielding, R.A., Selinger, S.I., Weiner, D.E. 2023. Geriatric syndromes and health-related quality of life in older adults with chronic kidney disease: Ancillary analysis of the award randomized clinical trial. Kidney360. https://doi.org/10.34067/KID.0000000000000078.

Model organism life extending therapeutics modulate diverse nodes in the drug-gene-microbe tripartite human longevity interactome - (Peer Reviewed Journal)
Salekeen, R., Lustgarten, M., Didarul Islam, K. 2023. Model organism life extending therapeutics modulate diverse nodes in the drug-gene-microbe tripartite human longevity interactome. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2023.2192823.

Association of vascular health measures and physical function: a prospective analysis in the Framingham Heart Study - (Peer Reviewed Journal)
Sahni, S., Dufour, A., Wang, N., Kiel, D.P., Hannan, M., Jacques, P.F., Benjamin, E., Vasan, R.S., Murabito, J.M., Newman, A.B., Fielding, R.A., Mitchell, G.F., Hamburg, N. 2023. Association of vascular health measures and physical function: a prospective analysis in the Framingham Heart Study. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad097.

Novel potential targets for function-promoting therapies: orphan nuclear receptors, anti-inflammatory drugs, troponin activators, mas receptor agonists, and urolithin A - (Review Article)
Dioh, W., Narkar, V., Singh, A., Malik, A., Ferrucci, L., Tourette, C., Mariani, J., Vanmaanen, R., Fielding, R.A. 2023. Novel potential targets for function-promoting therapies: orphan nuclear receptors, anti-inflammatory drugs, troponin activators, mas receptor agonists, and urolithin A. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad072.

Exercise and behavior: adjuncts to pro-myogenic compounds for enhancing mobility in older adults - (Review Article)
Storer, T.W., Pahor, M., Woodhouse, L., Lachman, M.E., Fielding, R.A. 2023. Exercise and behavior: adjuncts to pro-myogenic compounds for enhancing mobility in older adults. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad041.

Synergistic strategies to accelerate the development of function promoting therapies: Lessons from operation warp speed and oncology drug development - (Review Article)
Correa-De-Araujo, R., Evans, W.J., Fielding, R.A., Krishnan, V., Carter, R., Appleby, J., Guralnik, J., Klickstein, L.B., Marks, P., Moore, A., Peschin, S., Shalender, B. 2023. Synergistic strategies to accelerate the development of function promoting therapies: Lessons from operation warp speed and oncology drug development. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad028.

Association of anorexia/appetite loss with malnutrition and mortality in older populations: a systematic literature review - (Peer Reviewed Journal)
Groarke, J., Tarasenko, L., Smoyer, K., Fielding, R., Francesco, L. 2023. Association of anorexia/appetite loss with malnutrition and mortality in older populations: a systematic literature review. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.13186.

Optimizing the design of clinical trials to evaluate the efficacy of function promoting therapies - (Review Article)
Bhasin, S., Cawthon, P., Correa-De-Arauju, R., Storer, T.W., Volpi, E., Newman, A.B., Evans, W.J., Fielding, R. 2023. Optimizing the design of clinical trials to evaluate the efficacy of function promoting therapies. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad024.

Recent sarcopenia definitions - prevalence, agreement and association with mortality among men: findings from five population-based cohorts - (Peer Reviewed Journal)
Westbury, L., Beaudart, C., Bruyere, O., Cauley, J.A., Cawthon, P., Cruz-Jentoft, A.J., Curtis, E., Ensrud, K., Fielding, R., Johansson, H., Kanis, J.A., Karlsson, M.K., Lane, N., Lengele, L., Lorentzon, M., McCloskey, E., Mellstrom, D., Newman, A.B., Ohlsson, C., Orwoll, E., Reginster, J., Ribom, E., Rosengren, B., Schousboe, J.T., Shiroma, E.J., Harvey, N.C., Dennison, E.M., Cooper, C., Kwok, T. 2023. Recent sarcopenia definitions - prevalence, agreement and association with mortality among men: findings from five population-based cohorts. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.13160.

Anorexia in medicare fee-for-service beneficiaries: A claims-based analysis of epidemiology and mortality - (Peer Reviewed Journal)
Dagenais, S., Fielding, R.A., Clark, S., Cantu, C., Prasad, S., Groarke, J. 2023. Anorexia in medicare fee-for-service beneficiaries: A claims-based analysis of epidemiology and mortality. Journal of Nutrition Health and Aging. https://doi.org/10.1007/s12603-023-1882-4.

Limited physician knowledge of sarcopenia: a survey - (Review Article)
Guralnik, J., Cawthon, P., Bhasin, S., Fielding, R.A., Magaziner, J., Cruz-Jentoft, A.J., Vellas, B., Clarke, L., Lattimer, L., Evans, W. 2023. Limited physician knowledge of sarcopenia: a survey. Journal of American Geriatric Society. https://doi.org/10.1111/jgs.18227.

Assessment and management of appetite loss in older adults: an ICFSR task force report - (Review Article)
Desouto-Barreto, P., Cesari, M., Morley, J.E., Gonzalez-Bautista, E., Rolland, Y., Azzolino, D., Vellas, B., Fielding, R. 2022. Assessment and management of appetite loss in older adults: an ICFSR task force report. The Journal of Frailty and Aging. https://doi.org/10.14283/jfa.2022.64.

Associations between biomarkers of cellular senescence and physical function in humans: Observation from the lifestyle interventions for elders (life) study - (Peer Reviewed Journal)
Fielding, R.A., Atkinson, E.J., Aversa, Z., White, T.A., Heeren, A.A., Achenbach, S.J., Mielke, M.M., Cummings, S.R., Pahor, M., Leeuwenburgh, C., Lebrasseur, N.K. 2022. Associations between biomarkers of cellular senescence and physical function in humans: Observation from the lifestyle interventions for elders (life) study. Nature Aging. https://doi.org/10.1007/s11357-022-00685-2.

Resilience: biological basis and clinical significance - A perspective from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - (Review Article)
Cesari, M., Azzolino, D., Lebrasseur, N.K., Whitson, H., Rooks, D., Sourdet, S., Angioni, D., Fielding, R., Vellas, B., Rolland, Y. 2022. Resilience: biological basis and clinical significance - A perspective from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force. The Journal of Frailty and Aging. https://doi.org/10.14283/jfa.2022.62.

Defining terms commonly used in sarcopenia research: a glossary proposed by the global leadership in sarcopenia (glis) steering committee - (Review Article)
Cawthon, P.M., Visser, M., Arai, H., Cruz-Jentoft, A.J., Kiel, D.P., Kirk, B., Rocco, B., Avan, S., Cooper, C., Binder, E., Landi, F., Duque, G., Woo, J., Avila-Funes, J.A., Chen, L., Bruyere, O., Fielding, R., Bhasin, S., Haehling, S.V., Cederholm, T. 2022. Defining terms commonly used in sarcopenia research: a glossary proposed by the global leadership in sarcopenia (glis) steering committee. European Geriatric Medicine. https://doi.org/10.1007/s41999-022-00706-5.

Effect of long-term exercise training on physical performance and cardiorespiratory function in adults with ckd: a randomized controlled trial - (Peer Reviewed Journal)
Weiner, D., Liu, C.K., Miao, S., Fielding, R.A., Katzel, L., Giffuni, J., Well, A., Selinger, S. 2023. Effect of long-term exercise training on physical performance and cardiorespiratory function in adults with CDK: a randomized controlled trial. American Journal of Kidney Diseases. https://doi.org/10.1053/j.ajkd.2022.06.008.

Characterization of cellular senescence in aging skeletal muscle - (Peer Reviewed Journal)
Zhang, X., Habiballa, L., Aversa, Z., Ng, Y., Sakamoto, A.E., England, D.A., Pearsall, V.M., White, T.A., Robinson, M.M., Rivas, D., Dasari, S., Hruby, A.J., Lagnado, A.B., Jachim, S.K., Granic, A., Sayer, A.A., Jurk, D., Lanza, I., Khosla, S., Fielding, R., Nair, K., Schafer, M., Passos, J.F., Lebrasseur, N.K. 2022. Characterization of cellular senescence in aging skeletal muscle. Nature Aging. https://doi.org/10.1038/s43587-022-00250-8.

Effect of structured, moderate exercise on kidney function decline in sedentary older adults: An ancillary analysis of the LIFE study randomized clinical trial - (Peer Reviewed Journal)
Shilpak, M.G., Sheshadri, A., Hsu, F., Chen, S., Jotwani, V., Tranah, G., Fielding, R.A., Liu, C., Ix, J., Coca, S. 2022. Effect of structured, moderate exercise on kidney function decline in sedentary older adults: An ancillary analysis of the LIFE study randomized clinical trial. JAMA Internal Medicine. 182(6):650-659. https://doi.org/10.1001/jamainternmed.2022.1449.

Challenges in the development of drugs for sarcopenia and frailty - report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - (Proceedings)
Cesari, M., Bernabei, R., Vellas, B., Fielding, R.A., Rooks, D., Azzolino, D., Mariani, J., Oliva, A., Bashin, S., Rolland, Y. 2022. Challenges in the development of drugs for sarcopenia and frailty - report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force. The Journal of Frailty and Aging. 11:135-142. https://doi.org/10.14283/jfa.2022.30.

Recommendations for reducing heterogeneity in handgrip strength protocols - (Review Article)
McGrath, R., Cawthon, P., Clark, B., Fielding, R., Lang, J., Tomkinson, G. 2022. Recommendations for reducing heterogeneity in handgrip strength protocols. The Journal of Frailty and Aging. 11:143-150. https://doi.org/10.14283/jfa.2022.21.

Appetite loss and anorexia of aging in clinical care: An ICFSR task force report - (Proceedings)
de Souto Barreto, P., Cesari, M., Morley, J.E., Roberts, S., Landi, F., Cederholm, T., Rolland, Y., Vellas, B., Fielding, R.A. 2022. Appetite loss and anorexia of aging in clinical care: An ICFSR task force report. The Journal of Frailty and Aging. 11:129-134. https://doi.org/10.14283/jfa.2022.14.

Effects of physical and cognitive training on falls and concern about falling in older adults: results from a randomized controlled trial - (Peer Reviewed Journal)
Turunen, K.M., Tirkkonen, A., Savikangas, T., Hanninen, T., Alen, M., Fielding, R., Kivipelto, M., Neely, A.S., Tormakangas, T., Sipila, S. 2021. Effects of physical and cognitive training on falls and concern about falling in older adults: results from a randomized controlled trial. Journals of Gerontology. 77(7):1430-1437. https://doi.org/10.1093/gerona/glab375.

Functional improvements to 6 months of physical activity are not related to changes in size or density of multiple lower-extremity muscles in mobility-limited older individuals - (Peer Reviewed Journal)
Skoglund, E., Lundberg, T.R., Rullman, E., Fielding, R.A., Kirn, D.R., Englund, D.A., von Berens, A., Koochek, A., Cederholm, T., Berg, H.E., Gustafsson, T. 2021. Functional improvements to 6 months of physical activity are not related to changes in size or density of multiple lower-extremity muscles in mobility-limited older individuals. Experimental Gerontology. 157:111631. https://doi.org/10.1016/j.exger.2021.111631.

Effects of low doses of L-carnitine tartrate and lipid multi-particulate formulated creatine monohydrate on muscle protein synthesis in myoblasts and bioavailability in humans and rodents - (Peer Reviewed Journal)
Fielding, R.A., Rivas, D.A., Grosicki, G.J., Ezzyat, Y., Ceglia, L., Price, L., Orhan, C., Sahin, K., Fowler, K., White, T., Durkee, S., Kritsch, K., Bellamine, A. 2021. Effects of low doses of L-carnitine tartrate and lipid multi-particulate formulated creatine monohydrate on muscle protein synthesis in myoblasts and bioavailability in humans and rodents. Nutrients. 13(11):3985. https://doi.org/10.3390/nu13113985.

miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition - (Peer Reviewed Journal)
Rivas, D.A., Peng, F., Benard, T., Sanchez Ramos da Silva , A., Fielding, R.A., Margolis, L. 2021. miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition. American Journal of Physiology - Cell Physiology. 321(6):C977-C991. https://doi.org/10.1152/ajpcell.00190.2021.

A whole-grain diet increases whole-body protein balance compared to a macronutrient-matched refined-grain diet - (Peer Reviewed Journal)
Mey, J.T., Godin, J., Scelsi, A.R., Kullman, E.L., Malin, S.K., Yang, S., Floyd, Z.E., Poulev, A., Fielding, R.A., Ross, A.B., Kirwan, J.P. 2021. A whole-grain diet increases whole-body protein balance compared to a macronutrient-matched refined-grain diet. Current Developments in Nutrition. 5:nzab121. https://doi.org/10.1093/cdn/nzab121.

The effects of a physical and cognitive training intervention vs. physical training alone on older adults' physical activity: A randomized controlled trial with extended follow-up during COVID-19 - (Peer Reviewed Journal)
Savikangas, T., Tormakangas, T., Tirkkonen, A., Alen, M., Fielding, R., Kivipelto, M., Rantalainen, T., Neely, A.S., Sipila, S. 2021. The effects of a physical and cognitive training intervention vs. physical training alone on older adults' physical activity: A randomized controlled trial with extended follow-up during COVID-19. PLOS ONE. 16(10):e0258559. https://doi.org/10.1371/journal.pone.0258559.

International exercise recommendations in older adults (ICFSR): Expert consensus guidelines - (Other)
Izquierdo, M., Merchant, R.A., Morley, J.E., Anker, S.D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E.L., Cesari, M., Chen, L., De Souto, B.P., Duque, G., Ferrucci, L., Fielding, R.A., Garcia-Hermoso, A., Gutierrez-Robledo, L.M., Harridge, S., D.R., Kirk, B., Kritchevsky, S.B., Landi, F., Lazarus, N., Martin, F., Marzetti, E., Pahor, M., Ramirez-Velez, R., Rodriguez-Manas, L., Rolland, Y., Ruiz, J.G., Theou, O., Villareal, D.T., Waters, D.L., Won Won, C., Woo, J., Vellas, B., Fiatrone, S.A. 2021. International exercise recommendations in older adults (ICFSR): Expert consensus guidelines . Journal of Nutrition Health and Aging. 25(7):824-853. https://doi.org/10.1007/s12603-021-1665-8.

Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review - (Review Article)
Pandey, A., Shah, S.J., Butler, J., Kellogg, Jr., D.L., Lewis, G.D., Forman, D., Mentz, R.J., Borlaug, B.A., Simon, M.A., Chirinos, J.A., Fielding, R.A., Volpi, E., Molina, A.J., Haykowsky, M.J., Sam, F., Goodpaster, B.H., Bertoni, A.G., Justice, J.N., White, J.P., Ding, J., Hummel, S.L., Lebrasseur, N.K., Taffet, G.E., Pipinos, I.I., Kitzman, D.W. 2021. Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review. Journal of the American College of Cardiology. 78(11):1166-1187. https://doi.org/10.1016/j.jacc.2021.07.014.

Impact of whey protein supplementation in a weight-loss intervention in rural dwelling adults: A feasibility study - (Peer Reviewed Journal)
Batsis, J.A., Petersen, C.L., Cook, S.B., Al-Nimr, R.I., Driesse, T., Pidgeon, D., Fielding, R. 2021. Impact of whey protein supplementation in a weight-loss intervention in rural dwelling adults: A feasibility study. Clinical Nutrition. 45:426-432. https://doi.org/10.1016/j.clnesp.2021.07.006.

What cut-point in gait speed best discriminates community-dwelling older adults with mobility complaints from those without? A pooled analysis from the sarcopenia definitions and outcomes consortium - (Peer Reviewed Journal)
Cawthon, P.M., Patel, S.M., Kritchevsky, S.B., Newman, A.B., Santanasto, A., Kiel, D.P., Travison, T.G., Lane, N., Cummings, S.R., Orwoll, E.S., Duchowny, K.A., Kwok, T., Hirani, V., Schousboe, J., Karlsson, M.K., Mellstrom, D., Ohlsson, C., Ljunggren, O., Xue, Q., Shardell, M., Jordan, J.M., Pencina, K.M., Fielding, R., Magaziner, J., Correa-De-Araujo, R., Bashin, S., Manini, T.M. 2021. What cut-point in gait speed best discriminates community-dwelling older adults with mobility complaints from those without? A pooled analysis from the sarcopenia definitions and outcomes consortium. Journals of Gerontology. https://doi.org/10.1093/gerona/glab183.

On Schrodinger's cat and evaluation of trials disrupted by the Covid19 pandemic: A critical appraisal - (Review Article)
Cesari, M., Calvani, R., Canevelli, M., Aprahamian, I., de Souto Barreto, P., Azzolino, D., Fielding, R., Vanacore, N., Inzitari, M., Marzetti, E. 2021. On Schrodinger's cat and evaluation of trials disrupted by the Covid19 pandemic: A critical appraisal. The Journal of Frailty and Aging. 10(4)310-312. https://doi.org/10.14283/jfa.2021.23.

Nutritional mediators of cellular decline and mitochondrial dysfunction in older adults - (Review Article)
Guralnik, J.M., Feige, J.N., Singh, A., Fielding, R.A. 2021. Nutritional mediators of cellular decline and mitochondrial dysfunction in older adults. Geriatrics. 6(2):37. https://doi.org/10.3390/geriatrics6020037.

Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial - (Peer Reviewed Journal)
Sipila, S., Tirkkonnen, A., Savikangas, T., Hanninen, T., Laukkanen, P., Alen, M., Fielding, R.A., Kivipelto, M., Kulmala, J., Rantanen, T., Sihvonen, S.E., Sillanpaa, E., Stigsdotter-Neely, A., Tormakangas, T. 2021. Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial. Scandinavian Journal of Medicine & Science in Sports. 31(7):1518-1533. https://doi.org/10.1111/sms.13960.

Urban-rural differences in the prevalence of muscle weakness and slow gait speed: A cross-sectional analysis from the NHANES (2001-2002 and 2011-2014) - (Peer Reviewed Journal)
Aziz, J.J., Reid, K.F., Batsis, J.A., Fielding, R.A. 2021. Urban-rural differences in the prevalence of muscle weakness and slow gait speed: A cross-sectional analysis from the NHANES (2001-2002 and 2011-2014). Journal of Aging Research & Lifestyle. 10:19-25. https://doi.org/10.14283/jarlife.2021.4.

Sarcopenia definitions as predictors of fracture risk independent of FRAX, falls, and BMD in the osteoporotic fractures in men (MrOS) study: a meta-analysis - (Peer Reviewed Journal)
Harvey, N.C., Orwoll, E., Kwok, T., Karlsson, M.K., Rosengren, B.E., Ribom, E., Cauley, J.A., Cawthon, P.M., Ensrud, K., Liu, E., Cruz-Jentoft, A.J., Fielding, R.A., Cooper, C., Kanis, J.A., Lorentzon, M., Ohlsson, C., Mellstrom, D., Johansson, H., Mccloskey, E. 2021. Sarcopenia definitions as predictors of fracture risk independent of FRAX, falls, and BMD in the osteoporotic fractures in men (MrOS) study: a meta-analysis. Journal of Bone and Mineral Research. 36(7):1235-1244. https://doi.org/10.1002/JBMR.4293.

Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed - (Peer Reviewed Journal)
Beavers, D.P., Kritchevsky, S.B., Gill, T.M., Ambrosius, W.T., Anton, S.D., Fielding, R.A., King, A.C., Rejeski, W., Lovato, L., McDermott, M.M., Newman, A.B., Pahor, M., Walkup, M.P., Tracy, R.P., Manini, T.M. 2021. Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed. Journals of Gerontology. https://doi.org/10.1093/gerona/glab093.

Identifying biomarkers for biological age: geroscience and the ICFSR task force - (Review Article)
Lebrasseur, N.K., De Cabo, R., Fielding, R.A., Ferrucci, L., Rodriguez-Manas, L., Vina, J., Vellas, B. 2021. Identifying biomarkers for biological age: geroscience and the ICFSR task force. The Journal of Frailty and Aging. 10:196-201. https://doi.org/10.14283/jfa.2021.5.

Relationships between level and change in sarcopenia and other body composition components and adverse health outcomes: findings from the health, aging, and body composition study - (Peer Reviewed Journal)
Westbury, L.D., Syddall, H.E., Fuggle, N.R., Dennison, E.M., Harvey, N.C., Cauley, J.A., Shiroma, E.J., Fielding, R., Newman, A.B., Cooper, C. 2020. Relationships between level and change in sarcopenia and other body composition components and adverse health outcomes: findings from the health, aging, and body composition study. Calcified Tissues International. 108:302-313. https://doi.org/10.1007/s00223-020-00775-3.

Osteoporosis in frail older adults: recommendations for research from the ICFSR task force 2020 - (Other)
Rolland, Y., Cesari, M., Fielding, R., Reginster, J., Vellas, B., Cruz-Jentoft, A.J. 2021. Osteoporosis in frail older adults: recommendations for research from the ICFSR task force 2020. The Journal of Frailty and Aging. https://doi.org/10.14283/jfa.2021.4.

Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults - (Peer Reviewed Journal)
Reginster, J., Beaudart, C., Al-Daghri, N., Avouac, B., Bauer, J., Bere, N., Bruyere, O., Cerreta, F., Cesari, M., Rosa, M., Cooper, C., Cruz Jentoft, A.J., Dennison, E., Geerinck, A., Gielen, E., Landi, F., Laslop, A., Maggi, S., Concepcion Prieto, Y., Rizzoli, R., Sundseth, H., Sieber, C., Trombetti, A., Vellas, B., Veronese, N., Visser, M., Vlaskovska, M., Fielding, R.A. 2020. Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-020-01663-4.

The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: the ENRGISE pilot study - (Peer Reviewed Journal)
Custodero, C., Anton, S.D., Beavers, D.P., Mankowski, R.T., Lee, S.A., McDermott, M.M., Fielding, R.A., Newman, A.B., Tracy, R.P., Kritchevsky, S.B., Ambrosius, W.T., Pahor, M., Manini, T.M. 2020. The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: the ENRGISE pilot study. Archives of Gerontology and Geriatrics. 90. Article 104131. https://doi.org/10.1016/j.archger.2020.104131.

Sarcopenia, frailty, and gero-science: A decade of progress and a bright future of discovery - (Other)
Fielding, R.A. 2020. Sarcopenia, frailty, and gero-science: A decade of progress and a bright future of discovery. The Journal of Frailty and Aging. 10: 82-83. https://doi.org/10.14283/jfa.2020.37.

Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis - (Peer Reviewed Journal)
Cawthon, P.M., Manini, T., Patel, S.M., Newman, A., Travison, T., Kiel, D.P., Santanasto, A.J., Ensrud, K.E., Xue, Q., Shardell, M., Duchowny, K., Erlandson, K.M., Pencina, K.M., Fielding, R.A., Magaziner, J., Kwok, T., Karlsson, M., Ohlsson, C., Mellstrom, D., Hirani, V., Ribom, E., Correa-De-Araujo, R., Bhasin, S. 2020. Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis. Journal of the American Geriatrics Society. 68:1429-1437. https://doi.org/10.1111/jgs.16517.

Application of selected muscle strength and body mass cut points for the diagnosis of sarcopenia in men and women with or at risk for HIV infection - (Peer Reviewed Journal)
Erlandson, K.M., Travison, T.G., Zhu, H., Magaziner, J., Correa-De-Araujo, R., Cawthon, P.M., Bhasin, S., Manini, T., Fielding, R.A., Palella, F.J., Kingsley, L., Lake, J.E., Sharma, A., Tien, P.C., Weber, K.M., Yin, M.T., Brown, T.T. 2020. Application of selected muscle strength and body mass cut points for the diagnosis of sarcopenia in men and women with or at risk for HIV infection. Journal of Gerontology Medical Science. 75(7):1338-1345. https://doi.org/10.1093/gerona/glaa083.

Identification of sarcopenia components that discriminate slow walking speed: a pooled data analysis - (Peer Reviewed Journal)
Manini, T.M., Patel, S., Newman, A.B., Travison, T.G., Kiel, D.P., Shardell, M., Pencina, K., Wilson, K.E., Kelly, T.L., Masaro, J.M., Fielding, R.A., Magaziner, J., Correa-de-Araujo, R., Kwok, T.C., Hirani, V., Karlsson, M.K., D'Agostino, R., Mellstrom, D., Ohlsson, C., Ribom, E., Jordan, J.M., Bhasin, S., Cawthon, P.M. 2020. Identification of sarcopenia components that discriminate slow walking speed: a pooled data analysis. Journal of the American Geriatrics Society. 68(7):1419-1428. https://doi.org/10.1111/jgs.16524.

Application of cut-points for low muscle strength and lean mass in mobility-limited older adults - (Peer Reviewed Journal)
Grosicki, G., Travison, T.G., Zhu, H., Magaziner, J., Binder, E.F., Pahor, M., Correa-De-Araujo, R., Cawthon, P.M., Bhasin, S., Orwig, D., Greenspan, S., Manini, T., Massaro, J., Santanasto, A., Patel, S., Fielding, R.A. 2020. Application of cut-points for low muscle strength and lean mass in mobility-limited older adults. Journal of the American Geriatrics Society. 68:1445-1453. https://doi.org/10.1111/jgs.16525.

Sarcopenia definition: The position statements of the sarcopenia definition and outcomes consortium - (Peer Reviewed Journal)
Bhasin, S., Travison, T.G., Manini, T.M., Patel, S., Pencina, K.M., Fielding, R.A., Magaziner, J.M., Newman, A.B., Kiel, D.P., Cooper, C., Guralnik, J.M., Cauley, J.A., Arai, H., Clark, B.C., Landi, F., Schaap, L.A., Pereira, S.L., Rooks, D., Woo, J., Woodhouse, L.J., Binder, E., Brown, T., Shardell, M., Xue, Q., D'Agostino Sr., R.B., Orwig, D., Grosicki, G., Correa-de-Araujo, R., Cawthon, P.M. 2020. Sarcopenia definition: The position statements of the sarcopenia definition and outcomes consortium. Journal of the American Geriatrics Society. 68:1410-1418. https://doi.org/10.1111/jgs.16372.

Application of SDOC cut points for low muscle strength for recovery of walking speed after hip fracture - (Peer Reviewed Journal)
Orwig, D., Magaziner, J., Fielding, R.A., Zhu, H., Binder, E.F., Cawthon, P., Bhasin, S., Correa-De-Araujo, R., Manini, T., Patel, S., Shardell, M., Travison, T.G. 2020. Application of SDOC cut points for low muscle strength for recovery of walking speed after hip fracture. Journal of Gerontology Medical Science. 75(7):1379-1385. https://doi.org/10.1093/gerona/glaa076.

Investigation of the diet-gut-muscle axis in the Osteoporotic Fractures in Men study - (Peer Reviewed Journal)
Barger, K., Langsetmo, L., Orwoll, E.S., Lustgarten, M.S. 2020. Investigation of the diet-gut-muscle axis in the Osteoporotic Fractures in Men study. Journal of Nutrition Health and Aging. https://doi.org/10.1007/s12603-020-1344-1.

Sarcopenia definition & outcomes consortium defined low grip strength in two cross-sectional, population-based cohorts - (Peer Reviewed Journal)
Patel, S.M., Duchowny, K.A., Kiel, D.P., Correa-de-Araujo, R., Fielding, R.A., Travison, T., Magaziner, J., Manini, T., Xue, Q., Newman, A.B., Pencina, K.M., Santanasto, A., Bhasin, S., Cawthon, P.M. 2020. Sarcopenia definition & outcomes consortium defined low grip strength in two cross-sectional, population-based cohorts. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16419.

Long term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study - (Peer Reviewed Journal)
Westbury, L.D., Syddall, H.E., Fuggle, N.R., Dennison, E.M., Cauley, J.A., Shiroma, E.J., Fielding, R.A., Newman, A.B., Cooper, C. 2020. Long term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study. Calcified Tissue International. https://doi.org/10.1007/s00223-020-00679-2.

Associations of physical activity in detailed intensity ranges with body composition and physical function. a cross-sectional study among sedentary older adults - (Peer Reviewed Journal)
Savikangas, T., Tirkkonen, A., Alen, M., Rantanen, T., Fielding, R.A., Rantalainen, T., Sipila, S. 2020. Associations of physical activity in detailed intensity ranges with body composition and physical function. a cross-sectional study among sedentary older adults. European Review of Aging and Physical Activity. 17:4. https://doi.org/10.1186/s11556-020-0237-y.

Impact and lessons learned from the Lifestyle Intervention and Independence for Elders (LIFE) clinical trails of physical activity to prevent mobility disability - (Review Article)
Pahor, M., Guralnik, J.M., Anton, S.D., Ambrosius, W.T., Blair, S.N., Church, T.S., Espeland, M.A., Fielding, R.A., Gil, T.M., Glynn, N.W., Groessl, E.J., King, A.C., Kritchevsky, S.B., Manini, T.M., McDermott, M.M., Miller, M.E., Newman, A.B., Williamson, J.D. 2020. Impact and lessons learned from the Lifestyle Intervention and Independence for Elders (LIFE) clinical trails of physical activity to prevent mobility disability. Journal of the American Geriatrics Society. 00:1-10, 2020. https://doi.org/10.1111/jgs.16365.

The role of the gut microbiome on skeletal muscle mass and physical function: 2019 update - (Review Article)
Lustgarten, M. 2019. The role of the gut microbiome on skeletal muscle mass and physical function: 2019 update. Frontiers in Physiology. https://doi.org/10.3389/fphys.2019.01435.

AGS and NIA bench-to bedside conference summary: osteoporosis and soft tissue (muscle and fat) disorders - (Proceedings)
Colon-Emeric, C., Whitson, H.E., Berry, S.D., Fielding, R.A., Houston, D.K., Kiel, D., Rosen, C., Seldeen, K.L., Volpi, E., White, J.P., Troen, B.R. 2019. AGS and NIA bench-to bedside conference summary: osteoporosis and soft tissue (muscle and fat) disorders. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16248.

ICFSR task force perspective on biomarkers for sarcopenia and frailty - (Review Article)
Rodriguez-Manas, L., Araujo De Carvalho, I., Bhasin, S., Bischoff-Ferrara, H.A., Cesari, M., Evans, W., Hare, J.M., Pahor, M., Parini, A., Rolland, Y., Fielding, R.A., Watson, J., Vellas, B. 2019. ICFSR task force perspective on biomarkers for sarcopenia and frailty. The Journal of Frailty and Aging. 9(1):4-8. https://doi.org/10.14283/jfa.2019.32.

Impact of baseline fatigue on a physical ability intervention to prevent mobility disability - (Peer Reviewed Journal)
Glynn, N.W., Gmelin, T., Santanasto, A.J., Lovato, L.C., Lange-Maia, B.S., Nicklas, B.J., Fielding, R.A., Manini, T.M., Myers, V.H., De Rekeneire, N., Spring, B.J., Pahor, M., King, A.C., Rejeski, W., Newman, A.B. 2019. Impact of baseline fatigue on a physical ability intervention to prevent mobility disability. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16274.

The clinical impact and biological mechanisms of skeletal muscle aging - (Review Article)
Aversa, Z., Zhang, X., Fielding, R.A., Lanza, I., Lebrasseur, N.K. 2019. The clinical impact and biological mechanisms of skeletal muscle aging. Bone. 127:26-36. https://doi.org/10.1016/j.bone.2019.05.021.

The effects of tai chi mind-body approach on the mechanisms of gulf war illness: an umbrella review - (Review Article)
Reid, K.F., Bannuru, R.R., Wang, C., Mori, D.L., Niles, B.L. 2019. The effects of tai chi mind-body approach on the mechanisms of gulf war illness: an umbrella review. Integrative Medicine Research. 8(3):167-172. https://doi.org/10.1016/j.imr.2019.05.003.

Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on response to a physical activity intervention in older adults: results from the Lifestyle Interventions for Elders study - (Peer Reviewed Journal)
Brown, J.D., Smith, S.M., Strotmeyer, E.S., Kritchevsky, S.B., Gill, T.M., Blair, S.N., Fielding, R.A., Buford, T.W., Pahor, M., Manini, T.M. 2019. Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on response to a physical activity intervention in older adults: results from the Lifestyle Interventions for Elders study. Journals of Gerontology. https://doi.org/10.1093/gerona/glz120.

Is there enough evidence for osteosarcopenic obesity as a distinct entity? A critical literature review - (Review Article)
Bauer, J.M., Cruz-Jentoft, A.J., Fielding, R.A., Kanis, J.A., Reginster, J., Bruyere, O., Cesari, M., Chapurlat, R., Al-Daghri, N., Dennison, E., Kaufman, J., Landi, F., Laslop, A., Locquet, M., Maggi, S., Mccloskey, E., Perna, S., Rizzoli, R., Rolland, Y., Rondanelli, M., Szulc, P., Vellas, B., Vlaskovska, M., Cooper, C. 2019. Is there enough evidence for osteosarcopenic obesity as a distinct entity? A critical literature review. Calcified Tissue International. 105(2):109-124. https://doi.org/10.1007/s00223-019-00561-w.

Highlights from the 2019 International Congress on Frailty and Sarcopenia Research - (Other)
Maltais, M., Aubertin-Leheudre, M., Dray, C., Fielding, R.A., Rolland, Y., Cesare, M., Vellas, B. 2019. Highlights from the 2019 International Congress on Frailty and Sarcopenia Research. The Journal of Frailty and Aging. 8(3):117-119. https://doi.org/10.14283/jfa.2019.13.